CHIMGEN: Multi-center Imaging Genetics Studies in China
Study Details
Study Description
Brief Summary
To study the impact of genetic and environmental factors on high-level cognition associated neural circuits among healthy young Chinese Han subjects.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
The investigators plan to collect behavioral assessment and environmental factors data,peripheral blood sample, MRI brain images in more than 10,000 healthy young Chinese Han individuals in order to build the pathway from gene to high-level cognitive phenotypes.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Healthy young subjects Healthy young Chinese Han subjects aged 18-30 |
Outcome Measures
Primary Outcome Measures
- Brain structure and function measured by MRI scans [2 years]
The participants will receive non-interventional multi-modal MRI scans, such as 3D-T1WI, DTI, DKI, ASL, REST-fmri, then the investigators can acquire the brain volume in region of interest, such as bilateral hippocampus.
Secondary Outcome Measures
- Childhood adversities as assessed by Childhood Trauma Questionnaire-Short Form (Chinese Version) [2 years]
To investigate impact of the adversities in early life of participants on brain structure and function as well as the interaction effect of childhood adversities and genetic variations,such as 5-HTTLPR polymorphism.
Eligibility Criteria
Criteria
Inclusion Criteria:
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aged 18-30
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Chinese Han
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right-handed
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without history of neuropsychiatric disease
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no substance addiction
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smoking
Exclusion Criteria:
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younger or elder than 18-30 year-old
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other ethnics
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with history of neuropsychiatric disease
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with history of neuropsychiatric disease among first,second and third degree relatives
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Tianjin Medical University General Hospital | Tianjin | Tianjin | China | 300052 |
Sponsors and Collaborators
- Tianjin Medical University General Hospital
- Tianjin Medical University Cancer Institute and Hospital
- Tianjin Medical University Second Hospital
- Tianjin First Central Hospital
- Pingjin Hospital,Logistics University of Chinese People's Armed Police Forces
- School of Medical Imaging, Tianjin Medical University
- Tianjin Huanhu Hospital
- Beijing Hospital
- Chinese PLA General Hospital
- Beijing Tongren Hospital
- Xuanwu Hospital, Beijing
- Peking Union Medical College Hospital
- Beijing Normal University
- Chinese Academy of Sciences
- The Second Hospital of Hebei Medical University
- The First Affiliated Hospital of Shanxi Medical University
- Inner Mongolia Medical College Hospital
- The First Hospital of Jilin University
- The Frist Hospital Of China Medical University
- The First Affiliated Hospital of Dalian Medical University
- RenJi Hospital
- Huashan Hospital
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
- Nanjing PLA General Hospital
- The First Affiliated Hospital with Nanjing Medical University
- Xuzhou Medical University
- Second Affiliated Hospital, School of Medicine, Zhejiang University
- First Affiliated Hospital of Wenzhou Medical University
- The First Affiliated Hospital of Anhui Medical University
- Shan dong Medical Imaging Research Institute
- Qilu Hospital of Shandong University
- Yantai Yuhuangding Hospital
- Henan Provincial People's Hospital
- The First Affiliated Hospital of Zhengzhou University
- Tongji Hospital
- Wuhan University
- Xiangya Hospital of Central South University
- Central South University
- Guangdong Provincial People's Hospital
- The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine
- South China Normal UniversityćHainan General Hospital
- First Affiliated Hospital Xi'an Jiaotong University
- Xijing Hospital
- Tang-Du Hospital
- LanZhou University
- West China Hospital
- Second Affiliated Hospital of Wenzhou Medical University
- University of Electronic Science and Technology of China
- First Affiliated Hospital of Chongqing Medical University
- Southwest Hospital, China
- The University of Science and Technology of China
- Guangdong No.2 Provincial People's Hospital
Investigators
- Principal Investigator: Chunshui Yu, PhD, Tianjin Medical University General Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
- Braskie MN, Jahanshad N, Stein JL, Barysheva M, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ, Ringman JM, Toga AW, Thompson PM. Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. J Neurosci. 2011 May 4;31(18):6764-70. doi: 10.1523/JNEUROSCI.5794-10.2011.
- Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993 Aug 13;261(5123):921-3.
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