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Multidrug Resistance After Trabeculectomy With Mitomycin C

Sponsor
University of Cologne (Other)
Overall Status
Completed
CT.gov ID
NCT00449631
Collaborator
(none)
30
Enrollment
1
Location

Study Details

Study Description

Brief Summary

We investigate whether mitomycin C treatment during previous filtration surgery induces P-glycoprotein expression.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Despite the adjuvant use of mitomycin C during trabeculectomy, short-term and long-term failures still occur. We investigate whether mitomycin C treatment during previous trabeculectomy induces P-glycoprotein expression. Expression of P-glycoprotein is analysed in surgically removed Tenon tissue using immunohistochemistry.

    Study Design

    Study Type:
    Observational
    Time Perspective:
    Other
    Official Title:
    Multidrug Resistance After Trabeculectomy With Mitomycin C

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      8 Years to 85 Years
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:

      • patients with planned trabeculectomy for elevated eye pressure

      • one third of patients without previous trabeculectomy

      • two thirds of patients with previous trabeculectomy (one third with and one third without the use of mitomycin C)

      Exclusion Criteria:

      • patients not requiring surgery

      • patients with planned surgery for elevated eye pressure other than trabeculectomy

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 The University Hospital of Cologne Cologne Germany 50924

      Sponsors and Collaborators

      • University of Cologne

      Investigators

      • Principal Investigator: Arno Hueber, MD, University of Cologne

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00449631
      Other Study ID Numbers:
      • Multidrug Resistance
      First Posted:
      Mar 20, 2007
      Last Update Posted:
      Mar 26, 2007
      Last Verified:
      Mar 1, 2007
      Keywords provided by , ,
      Glaucoma
      Drug Resistance, Multiple
      Trabeculectomy
      Additional relevant MeSH terms:
      Glaucoma

      Study Results

      No Results Posted as of Mar 26, 2007