Multiparametric Echocardiography and Cardiac Biomarkers in Pediatric Inflammatory Heart Diseases
Study Details
Study Description
Brief Summary
Acquired inflammatory or infectious cardiac diseases, in pediatrics, include Kawasaki disease, myocarditis, and Covid-19-related Pediatric Multisystemic Inflammatory Syndrome (PIMS).
These 3 inflammatory cardiac diseases have clinical, biological, and echographic similarities and differences. Nevertheless their modalities of monitoring, management and evolution are different. The investigators wish to retrospectively analyze biological and echocardiographic data of Kawasaki disease, myocarditis, PIMS patients managed at Nancy Children Hospital from January 1, 2017 to June 31, 2023.
The primary objective of this study is to identify, for these 3 pathologies, the prognostic factors of initiation of inotropic support.
The secondary objective is to identify the prognostic factors of degradation of ventricular function.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| MYOCARDITIS No intervention Study of available clinical, biological, and echocardiographic data |
Other: study of biological samples and echocardiographic data and link with need of hemodynamic support
observational study : there is no intervention
|
| KAWASAKI No intervention Study of available clinical, biological, and echocardiographic data |
Other: study of biological samples and echocardiographic data and link with need of hemodynamic support
observational study : there is no intervention
|
| PIMS No intervention Study of available clinical, biological, and echocardiographic data |
Other: study of biological samples and echocardiographic data and link with need of hemodynamic support
observational study : there is no intervention
|
Outcome Measures
Primary Outcome Measures
- need of hemodynamic support [up to 20 days]
The need for haemodynamic support is defined dichotomously: yes or no. The investigators wish to identify the predictive factors of need for haemodynamic support among the following variables: groups (PIMS, KAWASAKI, MYOCARDITIS), cardiac biomarkers (troponin and NT-pro-BNP at admission (in ng/ml)) and echocardiographic criterias (LVEF , global and regional longitudinal strain at admission (in %)).
Secondary Outcome Measures
- deterioration of LVEF [up to 20 days]
LVEF degradation is defined as an LVEF below the value of the first quartile of LVEF of all patients taken into account (LVEF as a percentage). The investigators wish to identify the predictive factors of LVEF degradation among the following variables: groups (PIMS, KAWASAKI, MYOCARDITIS), cardiac biomarkers (troponin and NT-pro-BNP at admission (in ng/ml)) and echocardiographic criterias (LVEF, global and regional longitudinal strain at admission (in %)).
Eligibility Criteria
Criteria
Inclusion Criteria:
-
diagnostic of PIMS, myocarditis or kawasaki disease patients
-
age < 18 years
Exclusion Criteria:
-
uncertain diagnosis
-
other complex heart disease
-
management out of Nancy University children hospital center
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Gilles BOSSER | Vandœuvre-lès-Nancy | France | 54511 |
Sponsors and Collaborators
- Central Hospital, Nancy, France
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2023PI058