A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma

Sponsor

Bristol-Myers Squibb (Industry)

Overall Status

Not yet recruiting

CT.gov ID

NCT05827016

Collaborator

(none)

1,216

Enrollment

274

Locations

Arms

150.6

Anticipated Duration (Months)

4.4

Patients Per Site

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to compare the effectiveness of iberdomide maintenance to lenalidomide maintenance therapy after autologous stem cell transplantation (ASCT) in participants with newly diagnosed multiple myeloma (NDMM).

Condition or Disease	Intervention/Treatment	Phase
Multiple Myeloma	Drug: Iberdomide Drug: Lenalidomide	Phase 3

Study Design

Study Type:

Interventional

Anticipated Enrollment :

1216 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

A Phase 3, Two-stage, Randomized, Multi-center, Controlled, Open-label Study Comparing Iberdomide Maintenance to Lenalidomide Maintenance Therapy After Autologous Stem Cell Transplantation (ASCT) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) (EXCALIBER-Maintenance)

Anticipated Study Start Date :

Jun 15, 2023

Anticipated Primary Completion Date :

Mar 15, 2029

Anticipated Study Completion Date :

Jan 1, 2036

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Arm A1: Iberdomide Dose 1	Drug: Iberdomide Specified dose on specified days Other Names: CC-220 BMS-986382
Experimental: Arm A2: Iberdomide Dose 2	Drug: Iberdomide Specified dose on specified days Other Names: CC-220 BMS-986382
Experimental: Arm A3: Iberdomide Dose 3	Drug: Iberdomide Specified dose on specified days Other Names: CC-220 BMS-986382
Active Comparator: Arm B: Lenalidomide	Drug: Lenalidomide Specified dose on specified days Other Names: Revlimid®

Outcome Measures

Primary Outcome Measures

Progression-free survival (PFS) [Up to 6 years]

Secondary Outcome Measures

Achieving minimal residual disease (MRD) negativity in participants with complete response (CR) or better at 12 (± 3) months of maintenance treatment [Up to 6 years]
Overall Survival [Up to 12 years]
Recommended iberdomide dose for Stage 2 [Up to 1 year]
Area under the iberdomide plasma concentration-time curve from time zero to tau [Up to 1 year]
Area under the iberdomide plasma concentration-time curve within a dosing interval AUC (TAU) [Up to 1 year]
Maximum iberdomide concentration (Cmax) [Up to 1 year]
Time to maximum iberdomide plasma concentration (Tmax) [Up to 1 year]
Number of participants with adverse events (AEs) [Up to 6 years]
Progression-free survival on next line of treatment (PFS2) [Up to 6 years]
Achieving MRD negativity in participants with CR or better at any time after the date of randomization [Up to 6 years]
Conversion from MRD positive to MRD negative in participants with CR or better [Up to 6 years]
Achievement of CR or better and maintaining MRD-negative status in 2 bone marrow aspirate assessments that are a minimum of 6 months or 1 year apart, without any examination showing MRD positive status in between assessments [Up to 6 years]
Time to progression (TTP) [Up to 6 years]
Time to next treatment (TTNT) [Up to 6 years]
Best response achieved prior to progressive disease (PD) [Up to 6 years]
Patient-reported health-related quality of life (HRQoL) outcomes and multiple myeloma-related symptoms as measured by the European Organization for Research and Treatment of Cancer [EORTC] Quality of Life C30 questionnaire (QLQ-C30) [Up to 6 years]
Patient-reported HRQoL outcomes and multiple myeloma-related symptoms as measured by the EORTC Quality of Life Multiple Myeloma Module (QLQ-MY20) [Up to 6 years]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria

Confirmed diagnosis of symptomatic multiple myeloma (MM)
Eastern Cooperative Oncology Group performance status (ECOG) score of 0, 1, or 2
Received 3 to 6 cycles of an induction therapy that includes a proteasome inhibitor (PI) and immunomodulatory (IMiD) [eg, bortezomib thalidomide and dexamethasone (VTd), lenalidomide, bortezomib and dexamethasone (RVd)] with or without a CD38 monoclonal antibody, or Velcade® (bortezomib), cyclophosphamide, dexamethasone (VCd), and followed by a single or tandem autologous stem cell transplantation (ASCT). Post-stem cell transplant consolidation is permitted
Participants within 12 months from initiation of induction therapy who achieved at least a partial response (PR) after autologous stem cell transplantation (ASCT) with or without consolidation, according to International Myeloma Working Group (IMWG 2016) criteria

Exclusion Criteria

Progressive disease or clinical relapse (as defined by IMWG response criteria) following ASCT with or without consolidation or is not responsive to primary therapy
Smoldering myeloma, solitary plasmacytoma or nonsecretory myeloma
Known central nervous system/meningeal involvement of MM
Prior history of malignancies, other than MM, unless the participant has been free of the disease for ≥ 5 years

Other protocol-defined inclusion/exclusion criteria apply

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of California Irvine Medical Center (UCIMC) - Chao Family Comprehensive Cancer Center	Orange	California	United States	92868
2	Rocky Mountain Cancer Centers	Aurora	Colorado	United States	80012-5405
3	Poudre Valley Health Care	Fort Collins	Colorado	United States	80528-3413
4	Mayo Clinic Florida	Jacksonville	Florida	United States	32224-1865
5	Woodlands Medical Specialists - Pensacola	Pensacola	Florida	United States	32503-2339
6	H. Lee Moffitt Cancer Center & Research Institute	Tampa	Florida	United States	33612-9416
7	Cleveland Clinic Florida	Weston	Florida	United States	33331-3609
8	University Cancer & Blood Center, LLC	Athens	Georgia	United States	30607-1465
9	The Winship Cancer Institute of Emory University	Atlanta	Georgia	United States	30322-1013
10	Augusta University - Georgia Cancer Center	Augusta	Georgia	United States	30912
11	The University of Chicago Medical Center - Duchossois Center for Advanced Medicine	Chicago	Illinois	United States	60637-1426
12	University of Kansas Cancer Center - The Richard and Annette Bloch Cancer Care Pavilion	Westwood	Kansas	United States	66205-2003
13	Maryland Oncology Hematology, PA- Clinton	Clinton	Maryland	United States	20735-4230
14	University of Michigan Rogel Comprehensive Cancer Center UMCCC	Ann Arbor	Michigan	United States	48109-5000
15	Henry Ford Health System - The Henry Ford Cancer Institute (HFCI) - Detroit	Detroit	Michigan	United States	48202-2610
16	St. John Hospital and Medical Center - Van Elslander Cancer Center	Grosse Pointe Woods	Michigan	United States	48236-2858
17	Mayo Clinic - Transplant Center - Rochester	Rochester	Minnesota	United States	55905-0001
18	Hattiesburg Clinic - Hematology & Oncology	Hattiesburg	Mississippi	United States	39401
19	Midwest Oncology Associates - Kansas City	Kansas City	Missouri	United States	64132
20	Dartmouth-Hitchcock Medical Center (DHMC)	Lebanon	New Hampshire	United States	03756-1000
21	Morristown Medical Center	Morristown	New Jersey	United States	07960
22	Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	United States	08901-1914
23	NYU Langone Health	New York	New York	United States	10016-6402
24	Memorial Sloan-Kettering Cancer Center	New York	New York	United States	10021-0005
25	Columbia University Medical Center - Herbert Irving Pavilion Location	New York	New York	United States	10032-3729
26	Novant Health Cancer Institute - Elizabeth	Charlotte	North Carolina	United States	28803-2493
27	Oncology Hematology Care, Inc. - Cincinnati - Galbraith Rd	Cincinnati	Ohio	United States	45236-2725
28	Cleveland Clinic	Cleveland	Ohio	United States	44195
29	Toledo Clinic Cancer Centers	Toledo	Ohio	United States	43623
30	Willamette Valley Cancer Institute	Eugene	Oregon	United States	97401
31	Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	United States	19107
32	Fox Chase Cancer Center	Philadelphia	Pennsylvania	United States	19111-2497
33	University of Pittsburgh - Hillman Cancer Center	Pittsburgh	Pennsylvania	United States	15232
34	Cancer Care Associates of York	York	Pennsylvania	United States	17403-5049
35	Tennessee Oncology - Chattanooga Oncology & Hematology Associates	Chattanooga	Tennessee	United States	37404-1130
36	Tennessee Oncology	Nashville	Tennessee	United States	37203-1625
37	Texas Oncology - Baylor Charles A. Sammons Cancer Center	Dallas	Texas	United States	75246
38	UT Southwestern-Harold C. Simmons Cancer Center	Dallas	Texas	United States	75390-0001
39	University of Texas MD Anderson Cancer Center	Houston	Texas	United States	77030
40	University of Wisconsin Hospital and Clinics	Madison	Wisconsin	United States	53792-0001
41	Froedtert & Medical College of Wisconsin - Froedtert Hospital - Clinical Cancer Center	Milwaukee	Wisconsin	United States	53226-1222
42	Local Institution - 0184	Buenos Aires	B	Argentina	C1114AAN
43	Local Institution - 0259	Mar del Plata	B	Argentina	7600
44	Local Institution - 0267	Pilar	B	Argentina	B1629AHJ
45	Local Institution - 0183	Ciudad Autonoma Buenos Aires	Caba	Argentina	C1199ABB
46	Local Institution - 0227	Ciudad Autonoma Buenos Aires	Caba	Argentina	C1430EFA
47	Local Institution - 0182	Córdoba		Argentina	X5000JHGQ
48	Local Institution - 0244	Waratah	New South Wales	Australia	2298
49	Local Institution - 0088	Adelaide	South Australia	Australia	5000
50	Local Institution - 0220	Box Hill	Victoria	Australia	3128
51	Local Institution - 0076	Heidelberg	Victoria	Australia	3084
52	Local Institution - 0078	Clayton		Australia	3800
53	Local Institution - 0103	Nedlands		Australia	6009
54	Local Institution - 0090	Randwick		Australia	2031
55	Local Institution - 0058	Linz		Austria	4020
56	Local Institution - 0034	St. Pölten		Austria	3100
57	Local Institution - 0056	Vienna		Austria	1090
58	Local Institution - 0048	Kortrijk	VWV	Belgium	8500
59	Local Institution - 0035	Gilly		Belgium	6060
60	Local Institution - 0245	Curitiba	PR	Brazil	80520-174
61	Local Institution - 0214	Niterói	RJ	Brazil	24020-096
62	Local Institution - 0277	Sao Paulo	SP	Brazil	04537-080
63	Local Institution - 0241	São Paulo	SP	Brazil	08270-070
64	Local Institution - 0190	Barretos		Brazil	14784-400
65	Local Institution - 0083	Porto Alegre		Brazil	90880-480
66	Local Institution - 0081	Ribeirao Preto		Brazil	14051-140
67	Local Institution - 0082	Rio de Janeiro		Brazil	20231-050
68	Local Institution - 0096	Rio de Janeiro		Brazil	21941-913
69	Local Institution - 0098	Salvador		Brazil	40110-150
70	Local Institution - 0194	Sao Paulo		Brazil	01246-000
71	Local Institution - 0208	Ottawa	Ontario	Canada	K1H 8L6
72	Local Institution - 0270	Edmonton		Canada	T6G 1Z2
73	Local Institution - 0210	Quebec		Canada
74	Local Institution - 0213	Vancouver		Canada	V5Z 4C2
75	Local Institution - 0089	Los Ángeles	Bi	Chile	4440000
76	Local Institution - 0086	Providencia	RM	Chile	7500000
77	Local Institution - 0186	Santiago		Chile	7500691
78	Local Institution - 0258	Temuco		Chile	4810469
79	Local Institution - 0099	Vitacura		Chile	7650567
80	Local Institution - 0196	Hefei	AH	China	230001
81	Local Institution - 0100	Beijing Shi	Beijing	China	100020
82	Local Institution - 0216	Beijing	Beijing	China	101199
83	Local Institution - 0261	Guangzhou Shi	Guangdong	China	510080
84	Local Institution - 0079	Guangzhou	Guangdong	China	510060
85	Local Institution - 0256	Shenzhen	Guangdong	China	518028
86	Local Institution - 0246	Zhengzhou	Hainan	China	450004
87	Local Institution - 0084	Wuhan	HB	China	430200
88	Local Institution - 0262	Changsha	Hunan	China	410008
89	Local Institution - 0266	Nanjing	Jiangsu	China	210008
90	Local Institution - 0239	Xuzhou	Jiangsu	China	221000
91	Local Institution - 0263	Nanchang	Jiangxi	China	330200
92	Local Institution - 0091	Changchun	Jilin	China	130021
93	Local Institution - 0094	Shenyang	Liaoning	China	110022
94	Local Institution - 0265	Xi'an City	Shaanxi	China	710032
95	Local Institution - 0240	Jinan	Shandong	China	250012
96	Local Institution - 0271	Shanghai	Shanghai	China	200003
97	Local Institution - 0223	Shanghai	Shanghai	China	200020
98	Local Institution - 0085	Tianjin	Tianjin	China	300011
99	Local Institution - 0102	Tianjin	Tianjin	China	300020
100	Local Institution - 0249	Tianjin	Tianjin	China	30060
101	Local Institution - 0243	Hangzhou	Zhejiang	China	310003
102	Local Institution - 0229	Beijing		China	100853
103	Local Institution - 0212	Binzhou		China	256603
104	Local Institution - 0234	Changsha		China	410011
105	Local Institution - 0242	Chongqing		China	400016
106	Local Institution - 0080	Hangzhou Shi		China	310003
107	Local Institution - 0095	Nanchang Shi		China	330002
108	Local Institution - 0231	Nanjing		China	210029
109	Local Institution - 0247	Nanning Shi		China	530021
110	Local Institution - 0077	Qingdao		China	266071
111	Local Institution - 0087	Wenzhou Shi		China	325000
112	Local Institution - 0248	Wuhan Shi		China	430022
113	Local Institution - 0217	Bogota		Colombia	110111
114	Local Institution - 0211	Bogota		Colombia	110131
115	Local Institution - 0101	Floridablanca		Colombia	681004
116	Local Institution - 0179	Medellin		Colombia	050022
117	Local Institution - 0093	Valledupar		Colombia	200001
118	Local Institution - 0036	Brno		Czechia	625 00
119	Local Institution - 0049	Hradec Kralove		Czechia	500 05
120	Local Institution - 0206	Olomouc		Czechia	779 00
121	Local Institution - 0067	Ostrava		Czechia	708 52
122	Local Institution - 0215	Prague		Czechia	100 34
123	Local Institution - 0069	Praha		Czechia	128 00
124	Local Institution - 0028	Odense		Denmark	5000
125	Local Institution - 0276	Helsinki		Finland	00290
126	Local Institution - 0201	Kuopio		Finland	70211
127	Local Institution - 0030	Amiens		France	80054
128	Local Institution - 0235	Bayonne		France	64109
129	Local Institution - 0055	Caen		France	14033
130	Local Institution - 0050	Creteil		France	94000
131	Local Institution - 0236	La Roche Sur Yon CEDEX 9		France	85925
132	Local Institution - 0054	Lille		France	59037
133	Local Institution - 0221	Limoges		France	87042
134	Local Institution - 0222	Lyon		France	69008
135	Local Institution - 0272	Nantes		France	44093
136	Local Institution - 0254	Nice		France	06189
137	Local Institution - 0033	Paris		France	75010
138	Local Institution - 0219	Paris		France	75012
139	Local Institution - 0228	Paris		France	75013
140	Local Institution - 0066	Pierre Benite		France	69495
141	Local Institution - 0051	Toulouse		France	31059
142	Local Institution - 0061	Villejuif		France	94805
143	Local Institution - 0092	Ulm	BW	Germany	89081
144	Local Institution - 0022	Dusseldorf	Northwest	Germany	40225
145	Local Institution - 0026	Hamm	Northwest	Germany	59073
146	Local Institution - 0037	Berlin		Germany	13353
147	Local Institution - 0045	Freiburg		Germany	79106
148	Local Institution - 0038	Jena		Germany	07747
149	Local Institution - 0040	Tübingen		Germany	72076
150	Local Institution - 0209	Thessaloniki	B	Greece	570 10
151	Local Institution - 0097	Rio	G	Greece	265 04
152	Local Institution - 0185	Athina	I	Greece	106 76
153	Local Institution - 0233	Athens		Greece	115 28
154	Local Institution - 0063	Thessaloniki		Greece	546 39
155	Local Institution - 0250	Hong Kong	HK	Hong Kong	999077
156	Local Institution - 0062	Debrecen	HB	Hungary	4032
157	Local Institution - 0047	Haifa		Iceland	31999
158	Local Institution - 0128	Chandigarh	CH	India	160012
159	Local Institution - 0109	Cochin	KL	India	68202
160	Local Institution - 0200	Kolhapur	MH	India	416002
161	Local Institution - 0152	Nagpur	MH	India	440030
162	Local Institution - 0123	Pune	MH	India	411 004
163	Local Institution - 0142	Pune	MH	India	411004
164	Local Institution - 0124	Bhubaneswar	Odisha	India	751007
165	Local Institution - 0125	Kolkata	WB	India	700 020
166	Local Institution - 0110	Bangalore		India	560 001
167	Local Institution - 0135	Navi Mumbai		India	410 210
168	Local Institution - 0137	Beer Ya'Aqov		Israel	70300
169	Local Institution - 0027	Hadera		Israel	38100
170	Local Institution - 0060	Jerusalem		Israel	91000
171	Local Institution - 0075	Jerusalem		Israel	91031
172	Local Institution - 0108	Petah Tikva		Israel	49100
173	Local Institution - 0131	Ramat Gan		Israel	52621
174	Local Institution - 0136	Tel Aviv-Yafo		Israel	64239
175	Local Institution - 0057	Tel Aviv-Yafo		Israel	69710
176	Local Institution - 0053	Catania	CT	Italy	95123
177	Local Institution - 0120	Catanzaro	CZ	Italy	88100
178	Local Institution - 0115	Genova	GE	Italy	16132
179	Local Institution - 0188	Milano	MI	Italy	20122
180	Local Institution - 0071	Milano	MI	Italy	20162
181	Local Institution - 0139	Pisa	PI	Italy	56127
182	Local Institution - 0046	Roma	RM	Italy	00168
183	Local Institution - 0140	Torino	TO	Italy	10126
184	Local Institution - 0041	Bergamo		Italy	24127
185	Local Institution - 0042	Catanzaro		Italy	88100
186	Local Institution - 0074	Naples		Italy	80131
187	Local Institution - 0065	Rome		Italy	00161
188	Local Institution - 0141	Chiba-shi		Japan	260-8677
189	Local Institution - 0118	Gifu-shi		Japan	500-8513
190	Local Institution - 0133	Higashiibaraki-Gun		Japan	311-3193
191	Local Institution - 0112	Hiroshima-shi		Japan	730-8619
192	Local Institution - 0199	Isehara-shi		Japan	259-1193
193	Local Institution - 0111	Kagoshima-Shi		Japan	890-8520
194	Local Institution - 0197	Kamakura-Shi		Japan	247-8533
195	Local Institution - 0144	Kanazawa-Shi		Japan	920-8641
196	Local Institution - 0134	Kobe-Shi		Japan	650-0047
197	Local Institution - 0122	Koto-Ku		Japan	135-8550
198	Local Institution - 0198	Kumamoto-shi		Japan	860-8556
199	Local Institution - 0121	Maebashi-Shi		Japan	371-8511
200	Local Institution - 0150	Minato-ku		Japan	105-8471
201	Local Institution - 0104	Nagasaki-Shi		Japan	852-8511
202	Local Institution - 0143	Nagoya-Shi		Japan	467-8602
203	Local Institution - 0268	Osakasayama-shi		Japan	589-8511
204	Local Institution - 0148	Saitama-shi		Japan	330-8503
205	Local Institution - 0105	Sapporo-shi		Japan	003-0006
206	Local Institution - 0132	Sendai-shi		Japan	983-8520
207	Local Institution - 0106	Shibukawa-shi		Japan	377-0280
208	Local Institution - 0116	Shibuya-Ku		Japan	150-8935
209	Local Institution - 0130	Shizuoka-shi		Japan	411-8777
210	Local Institution - 0225	Dong-Gu	Ulsan	Korea, Republic of	44033
211	Local Institution - 0145	Busan		Korea, Republic of	49241
212	Local Institution - 0113	Goyang-si		Korea, Republic of	410-769
213	Local Institution - 0114	Seoul		Korea, Republic of	135-710
214	Local Institution - 0127	Mexico	CMX	Mexico	14080
215	Local Institution - 0147	Guanajuato	GTO	Mexico	37660
216	Local Institution - 0146	Toluca De Lerdo	MEX	Mexico	50090
217	Local Institution - 0264	Hermosillo	SON	Mexico	83270
218	Local Institution - 0107	Mexico city		Mexico	04100
219	Local Institution - 0129	Amsterdam	NH	Netherlands	1081 HV
220	Local Institution - 0070	Dordrecht		Netherlands	3300 AK
221	Local Institution - 0149	Bydgoszcz	KP	Poland	85-168
222	Local Institution - 0251	Lodz	LD	Poland	93-510
223	Local Institution - 0195	Gdansk	Pomorskie	Poland	80-211
224	Local Institution - 0252	Gliwice		Poland	44-102
225	Local Institution - 0039	Katowice		Poland	40-749
226	Local Institution - 0059	Lodz		Poland	93-509
227	Local Institution - 0044	Lublin		Poland	20-134
228	Local Institution - 0119	Warsaw		Poland	02-781
229	Local Institution - 0031	Wroclaw		Poland	50-367
230	Local Institution - 0255	Almada	Lisboa	Portugal	2805-267
231	Local Institution - 0023	Braga		Portugal	4710-243
232	Local Institution - 0151	Coimbra		Portugal	3000-075
233	Local Institution - 0126	Porto		Portugal	4200-072
234	Local Institution - 0117	Bucureşti	B	Romania	022328
235	Local Institution - 0043	Craiova	Dolj	Romania	200143
236	Local Institution - 0224	Iasi	IS	Romania	700483
237	Local Institution - 0064	Cluj-Napoca	Jud. Cluj	Romania	400015
238	Local Institution - 0072	Cluj-Napoca		Romania	400015
239	Local Institution - 0138	Singapore		Singapore	119074
240	Local Institution - 0187	Singapore		Singapore	169608
241	Local Institution - 0166	Oviedo	Asturias	Spain	33011
242	Local Institution - 0226	Barcelona	B	Spain	08036
243	Local Institution - 0169	Cáceres	CC	Spain	10003
244	Local Institution - 0172	Las Palmas de Gran Canaria	Las Palmas	Spain	35019
245	Local Institution - 0155	Murcia	MU	Spain	30120
246	Local Institution - 0174	Valencia	VC	Spain	46026
247	Local Institution - 0232	Badalona		Spain	08916
248	Local Institution - 0164	Palma de Mallorca		Spain	07120
249	Local Institution - 0163	Pamplona		Spain	31008
250	Local Institution - 0157	Stockholm	AB	Sweden	141 86
251	Local Institution - 0171	Luleå	BD	Sweden	971 80
252	Local Institution - 0230	Goeteborg		Sweden	413 46
253	Local Institution - 0170	Helsingborg		Sweden	254 37
254	Local Institution - 0218	Linkoping		Sweden	581 85
255	Local Institution - 0168	Aarau		Switzerland	5001
256	Local Institution - 0153	Kao-Hsiung		Taiwan	83301
257	Local Institution - 0175	Kaohsiung		Taiwan	82445
258	Local Institution - 0159	New Taipei City		Taiwan	220
259	Local Institution - 0165	Tainan		Taiwan	704
260	Local Institution - 0167	Ankara		Turkey	06230
261	Local Institution - 0158	Bornova		Turkey	35100
262	Local Institution - 0052	Edirne		Turkey	22030
263	Local Institution - 0068	Istanbul		Turkey	34214
264	Local Institution - 0073	Izmir		Turkey	35575
265	Local Institution - 0024	Kayseri		Turkey	38039
266	Local Institution - 0032	Yenimahalle		Turkey	06200
267	Local Institution - 0173	Aberdeen	ABD	United Kingdom	AB25 2ZN
268	Local Institution - 0156	Derby	DBY	United Kingdom	DE22 3NE
269	Local Institution - 0162	Bournemouth	DOR	United Kingdom	BH7 7DW
270	Local Institution - 0154	Stafford	STS	United Kingdom	ST16 3SA
271	Local Institution - 0160	Edinburgh		United Kingdom	EH4 2XU
272	Local Institution - 0025	London		United Kingdom	W1G 6AF
273	Local Institution - 0029	Oxford		United Kingdom	OX4 6LB
274	Local Institution - 0161	Windsor		United Kingdom	SL4 3HD