Study of SGN-40 in Patients With Refractory or Recurrent Multiple Myeloma

Sponsor

Seagen Inc. (Industry)

Overall Status

Completed

CT.gov ID

NCT00079716

Collaborator

Genentech, Inc. (Industry)

Enrollment

Locations

Arm

Duration (Months)

8.8

Patients Per Site

0.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to determine the safety and activity of SGN-40 in a weekly dosage schedule as a single agent.

Condition or Disease	Intervention/Treatment	Phase
Multiple Myeloma	Drug: SGN-40 (anti-huCD40 mAb)	Phase 1

Detailed Description

This is an open-label, multi-dose, single-arm, phase I, dose-escalation study to define the toxicity profile, maximum tolerated dose (MTD), pharmacokinetics, and antitumor activity of SGN-40 in patients with refractory or recurrent multiple myeloma.

A minimum of three patients will be entered into each dose-level cohort. All patients will receive a dose-loading schedule during the first two weeks. The maximum weekly dose will be 16mg/kg.

Study Design

Study Type:

Interventional

Actual Enrollment :

44 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

A Phase I, Multi-Dose Study of SGN-40 (Anti-huCD40 mAb) in Patients With Refractory or Recurrent Multiple Myeloma

Study Start Date :

Mar 1, 2004

Actual Primary Completion Date :

Aug 1, 2007

Actual Study Completion Date :

Nov 1, 2007

Arms and Interventions

Arm	Intervention/Treatment
Experimental: 1	Drug: SGN-40 (anti-huCD40 mAb) 0.5-8 mg/kg IV (in the vein) on Day 1; 0-8 mg/kg on Day 4; 0.5-16 mg/kg on Days 8 and 15; 0-16 mg/kg on Day 29. Other Names: dacetuzumab

Arm

Intervention/Treatment

Experimental: 1

Drug: SGN-40 (anti-huCD40 mAb)

0.5-8 mg/kg IV (in the vein) on Day 1; 0-8 mg/kg on Day 4; 0.5-16 mg/kg on Days 8 and 15; 0-16 mg/kg on Day 29.

Other Names:

dacetuzumab

Outcome Measures

Primary Outcome Measures

Adverse events and lab abnormalities. []

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Patients must have refractory or recurrent secretory multiple myeloma (MM).
Patients must have failed at least two different prior systemic therapies for MM.
Patients may have received a maximum of five cytotoxic regimens.
Patients who have received any of the following must complete within the specified time frame below:

Autologous stem cell transplant - 12 weeks prior to first dose
Nitrogen Mustard agents, Melphalan, BCNU, IVIG, or monoclonal antibody therapy - 6 weeks prior to first dose
Chemotherapy, Radiation, or other therapies for MM - 4 weeks prior to first dose

Patients who have not undergone autologous stem cell transplantation must be either ineligible for stem cell transplantation or, if eligible, must have refused treatment by autologous stem cell transplantation.
Patients must have an ECOG performance status of ≤ 2 and a life expectancy > three months.
Patients must be available for periodic blood sampling, study-related assessments, and management of toxicity at the treating institution for the entire duration of the study.
Patients must be at least 18 years of age.
Females of childbearing potential must have a negative β-HCG pregnancy test result within three days of enrollment. All patients must plan to use an effective contraceptive method during the course of the study.
Patients must meet baseline lab data requirements.
Patients must give written informed consent.

Exclusion Criteria:

Patients with non-secretory MM or solitary plasmacytoma or plasma cell leukemia.
Patients with a history of allogeneic transplantation.
Patients receiving plasmapheresis within four weeks prior to enrollment.
Patients undergoing major surgery within four weeks prior to enrollment.
Patients with a known hypersensitivity to recombinant proteins or any excipient contained in the drug formulation.
Patients with a history of other malignancies during the past five years with the exception of adequately treated basal or squamous cell skin cancer or cervical carcinoma in situ.
Patients with any active viral, bacterial, or systemic fungal infection within four weeks of enrollment.
Patients with a history of significant chronic or recurrent infections requiring treatment.
Patients with a history of active thrombosis within three months of enrollment.
Patients with a history of pulmonary embolism.
Patients with a history of migraines or severe headaches requiring medical therapy within 12 months of enrollment.
Patients who are pregnant or breastfeeding.
Patients with uncontrolled hypercalcemia.
Patients with any serious underlying medical condition that would impair their ability to receive or tolerate the planned treatment.
Patients with dementia or altered mental status that would preclude understanding and rendering of informed consent.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	James R. Berenson M.D., Inc.	West Hollywood	California	United States	90069
2	Rocky Mountain Cancer Center	Denver	Colorado	United States	80218
3	Dana Farber Cancer Institute	Boston	Massachusetts	United States	02115
4	Cornell University	New York	New York	United States	10021
5	The Cleveland Clinic	Cleveland	Ohio	United States	44195