Neurogenic Lower Urinary Tract Symptoms in Patients With Multiple Sclerosis
Study Details
Study Description
Brief Summary
There is no consensus in the literature upon the neurourological diagnostic algorithm of the patients with multiple sclerosis (MS). The primary aim of the study is phenotyping the patients with MS. These phenotypes might guide Neurology and Urology specialists during diagnosis and treatment. Secondary aim of this study is to define the presence and severity of urological symptoms' and disorders', involving the patients with diagnosis of MS less than 5 years into a urological follow-up and treatment process. Our study might include 4 visits (the first visit, 3rd month, 6th month and 12th month visit). Questionnaires, uroflowmetry and bladder diary might be repeated on each visit. Filling cystometry and pressure-flow study will be performed only on the first visit. All patients will receive 6 different questionnaires which aim to define the severity and presence of lower urinary tract symptoms. Bladder diary is an online application which will represent at least 3 days of frequency, urgency, incontinence episodes and the amount of fluid intake, and urination. The phenotypes would be defined after performing the first visit diagnostic tools (all of the tools are necessary during the diagnostic algorithm of neurogenic lower urinary tract symptoms). The phenotypes will be defined as: a. no symptoms with normal urodynamics, b. Lower urinary tract symptoms with normal urodynamics, c. no symptoms with abnormal urodynamics, d.lower urinary tract symptoms with abnormal urodynamics. During a follow-up period of 1 year, changes in the bladder diaries and scores in questionnaires of these groups will be compared on each visit.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Outcome Measures
Primary Outcome Measures
- Changes in Questionnaire Scores [every 3 months]
Bladder dysfunction
- Changes in Urodynamics [every 3 months]
Bladder dysfunction
Eligibility Criteria
Criteria
Inclusion Criteria:
The patients who are followed up by Department of Neurology with MS diagnosis less than 5 years
Exclusion Criteria:
-
Patients who are not eligible for completing questionnaires, bladder diaries.
-
Patients who have anatomical disorders preventing lithotomy position during urodynamic study.
-
Patients in relapsing period of MS
-
Patients who have symptoms of urinary tract infection
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Koç University | Istanbul | Turkey | 34010 |
Sponsors and Collaborators
- Koç University
Investigators
- Principal Investigator: Ersin Köseoğlu, Koç University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- KocUrol