Tissue Perfusion Indices as Predictor of Outcome in Poly Trauma Patients
Study Details
Study Description
Brief Summary
Early intervention and resuscitation based upon a lot of clinical, laboratory findings make a big difference regarding outcome in poly trauma patients, the study uses the dynamic lactate change and the difference between arterial and venous CO2, oxygen tension or content as indicators for tissue perfusion.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Poly trauma patients have high incidence of mortality and morbidity in spite of improvements and advances in facilities. However, no doubt that early resuscitation and interventions make a big difference upon the overall outcome.
A lot of methods, indices, laboratory and biomarkers have been utilized to evaluate the progress and quality of resuscitation and the early hospital interventions in such group of critically ill patients including central venous pressures, urine output, mixed venous oxygen saturation, and gastric tonometry. Most of recent means focus upon the regional tissue perfusion rather than global, however some researches have tried the difference between arterial and venous CO2,oxygen tension or content ( Pv -a co2& Pa -v O2 ) in addition to dynamic changes in lactate(3) as predictors for tissue perfusion in sepsis patients after establishment of sepsis campaign (bundle).
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Other: optimal resuscitation This group of multiple trauma patients will be resuscitated with crystalloids, analgesics, blood products as needed. Then follow up of the difference between arterial and venous CO2 to difference between arterial and venous oxygen tension, serum lactate, renal function, other organ affection along over the short hospital stay period |
Other: optimal resuscitation
optimal resuscitation to achieve mean arterial blood pressure above 65 mmHG , Central venous pressure more than 8 mmHg , urine out put more than 0.5 ml /Kg/hour
|
Outcome Measures
Primary Outcome Measures
- the difference between partial pressure of oxygen in arterial and venous blood [6 hours]
- the difference between partial pressure of carbon dioxide in arterial and venous blood [6 hours]
- serum level of lactate and its changes [6 hours]
as an index for tissue oxygenation
Secondary Outcome Measures
- Kidney function [72 hours]
serum creatinine in mg/ dl and urine output/ hour
- hemodynamic stability including pulse rate and mean arterial blood pressure [72 hours]
- duration of stay in the critical care unit [72 hours]
Eligibility Criteria
Criteria
Inclusion Criteria:
- multiple trauma patients Adult patients
Exclusion Criteria:
- cardiac renal chronic chest disease diabetic more than 3 years
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Emad Zarief Kamel Said | Assiut | Egypt | 71111 |
Sponsors and Collaborators
- Assiut University
Investigators
- Study Director: Emad Zarief Kamel Said, MD, Assiut University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- IRB00009902