ENDURE: Enforced Reduction in Physical Activity and Recovery in Older Adults
Study Details
Study Description
Brief Summary
Apparently healthy and well-functioning community dwelling 70-80 year-olds will be recruited to the study. All subjects undergo pre-screening for suitability and a physicians examination, as well as 7-day habitual daily steps are measured to ascertain baseline physical activity. Half of the recruited subjects (n=40) will be randomized into the intervention group and half (n=40) randomized into the control group. The intervention group is then required to reduce their daily steps to <2000 for a 2-week period. Thereafter, the intervention group participates to a 4-week strength+endurance training rehabilitation program and no longer has restricted daily step count. The control group continues their normal habitual physical activity level throughout the 6-week study period.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Intervention group Two weeks of daily step reduction (limited to 2000 steps per day) followed by four weeks of supervised gym-based exercise rehabilitation (twice per week strength training and twice per week cycle endurance training) |
Behavioral: Step-reduction/Exercise Rehab
2-week limited daily steps (<2000), and then 4 weeks of typical strength+endurance exercise for older adults
|
| No Intervention: Control group Continued monitoring of habitual daily step count without structured intervention. Classic control. |
Outcome Measures
Primary Outcome Measures
- Lean leg mass [6 weeks]
DXA-measured total lean mass of the legs
Secondary Outcome Measures
- Whole-body fat mass [6 weeks]
DXA-measured total body fat mass
- Maximum isometric leg extension force [6 weeks]
Maximum strength of legs
- Walking economy [6 weeks]
Oxygen uptake while walking at 3 and 5 km.h-1
- Short Physical Performance Battery (SPPB) [6 weeks]
Walking, balance and chair-rise tests
- Blood pressure [6 weeks]
Systolic and diastolic blood pressure during rest (sitting)
- HOMA indices [6 weeks]
Blood glucose and insulin concentration based calculations related to insulin resistance and beta-cell function
- White blood cell respiration [6 weeks]
Isolated white blood cell respiration as a marker for mitochondrial function
Eligibility Criteria
Criteria
Inclusion Criteria:
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aged 70-80 years,
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community-dwelling,
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able to walk 500 m without assistance or use of walking aid and regularly walking
5000 steps per day,
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MMSE >24,
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BMI 20-35 kg·m2 (i.e. not underweight or severely obese),
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no serious cardiovascular or musculoskeletal disease,
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no risk factors for deep-vein thrombosis (e.g. blood clotting disorder, obesity, bowel diseases, personal or family history of DVT etc.),
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non-smoker,
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provision of informed consent.
Exclusion Criteria:
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Underlying diseases likely to limit lifespan and/or intervention safety. Contraindication for physical exercise or physical tests identified during physician's examination,
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unwilling/unable to track daily step counts using accelerometer,
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excessive and regular use of alcohol (more than 7 units per week for women and 14 for men)
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difficulty in communication due to severe vision or hearing problems
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unwilling to provide consent or accept randomization into either study group
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- University of Jyvaskyla
- University of Eastern Finland
Investigators
- Principal Investigator: Simon Walker, PhD, University of Jyväskylä, Finland
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- SKR:271901-36456