Protein Ingestion and Muscle Carnitine Uptake

• Sponsor: University of Nottingham (Other)
• Overall Status: Completed
• CT.gov ID: NCT02535897
• Collaborator: (none)
• Enrollment: 7
• Arms: 3
• Duration (Months): 12

Study Details

Study Description

Brief Summary

The purpose of this study is to assess the effects of a protein-carbohydrate beverage on the absorption of an orally ingested bolus of L-carnitine, compared to flavoured water and carbohydrate-only controls, and to determine whether increasing plasma carnitine availability can impact upon insulin-stimulated muscle carnitine uptake.

Condition or Disease	Intervention/Treatment	Phase
Muscle, Skeletal	Dietary Supplement: Flavoured water; Dietary Supplement: Flavoured water + carbohydrate; Dietary Supplement: Flavoured water + carbohydrate + protein	Phase 1

Study Design

• Study Type: Interventional
• Actual Enrollment: 7 participants
• Allocation: Randomized
• Intervention Model: Crossover Assignment
• Masking: Single (Participant)
• Primary Purpose: Basic Science
• Official Title: The Effects of an Insulinotropic Protein-carbohydrate Beverage on L- Carnitine Absorption and Muscle Carnitine Uptake
• Study Start Date: Jul 1, 2013
• Actual Primary Completion Date: Feb 1, 2014
• Actual Study Completion Date: Jul 1, 2014

Arms and Interventions

Arm	Intervention/Treatment
Placebo Comparator: CON 500 ml of flavoured water	Dietary Supplement: Flavoured water
Active Comparator: CHO 500 ml of flavoured water containing 80 g carbohydrate	Dietary Supplement: Flavoured water + carbohydrate
Active Comparator: CHO-PRO 500 ml of flavoured water containing 40 g carbohydrate and 40 g whey protein	Dietary Supplement: Flavoured water + carbohydrate + protein

Outcome Measures

Primary Outcome Measures

1. Muscle carnitine uptake [180 minutes]

   Change in forearm carnitine uptake (measured using arterialised-venous - venous balance technique) in response to intervention.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 35 Years
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Healthy

• Body mass index of 18-25 kg/cm2

Exclusion Criteria:

• Unhealthy

• Smoker

• Taking any medication that interferes with skeletal muscle metabolism

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

• University of Nottingham

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: University of Nottingham
• ClinicalTrials.gov Identifier: NCT02535897
• Other Study ID Numbers: G26062012 BMS
• First Posted: Aug 31, 2015
• Last Update Posted: Aug 31, 2015
• Last Verified: Aug 1, 2015

Study Results

No Results Posted as of Aug 31, 2015