Myocardial Blood Flow by 15O Water PET

• Sponsor: University of Edinburgh (Other)
• Overall Status: Completed
• CT.gov ID: NCT01805193
• Collaborator: (none)
• Enrollment: 22
• Location: 1
• Duration (Months): 73
• Patients Per Site Per Month: 0.3

Study Details

Study Description

Brief Summary

Coronary heart disease is a very common condition caused by narrowings in the blood vessel supplying the heart. the investigators are studying new tests to diagnose heart disease. In this study the investigators plan to investigate a special scan called a PET/CT (Positron emission tomography/computed tomography) and a new type of CT (Computed tomography) scan to tell us about the flow of blood to the heart muscle.

Condition or Disease	Intervention/Treatment	Phase
Coronary Heart Disease	Other: Computed tomography myocardial perfusion imaging; Other: Oxygen 15 labelled water positron emission tomography

Detailed Description

Participants will undergo PET/CT with oxygen-15 labelled water and computed tomography myocardial perfusion imaging.

Study Design

• Study Type: Observational
• Actual Enrollment: 22 participants
• Observational Model: Cohort
• Time Perspective: Cross-Sectional
• Official Title: Validation of Computed Tomography Myocardial Perfusion Imaging Using Quantification of Myocardial Blood Flow by Positron Emission Tomography With 15O-water
• Study Start Date: Dec 1, 2012
• Actual Primary Completion Date: Jun 1, 2014
• Actual Study Completion Date: Jan 1, 2019

Arms and Interventions

Arm	Intervention/Treatment
Suspected coronary heart disease	Other: Computed tomography myocardial perfusion imaging; Other: Oxygen 15 labelled water positron emission tomography

Outcome Measures

Primary Outcome Measures

1. Myocardial blood flow [1 month]

   Myocardial blood flow ( ml/g/min) measured by oxygen-15 water positron emission tomography

Secondary Outcome Measures

1. Fractional flow reserve [1 month]

   Fractional flow reserve measured during invasive coronary angiography

2. Myocardial perfusion [1 month]

   Myocardial perfusion measured as hypoperfusion on adenosine computed tomography myocardial perfusion imaging

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• suspected coronary artery disease

Exclusion Criteria:

• inability or unwillingness to undergo CT or PET imaging

• renal failure (serum creatinine >200 um/L or eGFR <30 ml/min)

• hepatic failure

• allergy to iodinated contrast

• pregnancy

• contraindication to adenosine

• inability to give informed consent

• atrial fibrillation with a fast ventricular rate (>70 beats per minute)

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Clinical Research Imaging Centre	Edinburgh	Scotland	United Kingdom

Sponsors and Collaborators

• University of Edinburgh

Investigators

• Principal Investigator: David Newby, PhD DM, University of Edinburgh

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: University of Edinburgh
• ClinicalTrials.gov Identifier: NCT01805193
• Other Study ID Numbers: 12/SS/0078
• First Posted: Mar 6, 2013
• Last Update Posted: Feb 22, 2019
• Last Verified: Feb 1, 2019

• Keywords provided by University of Edinburgh: Coronary heart disease; computed tomography myocardial perfusion; positron emission tomography; oxygen 15 labelled water; myocardial perfusion; myocardial blood flow
• Additional relevant MeSH terms: Heart Diseases; Coronary Disease; Coronary Artery Disease; Myocardial Ischemia

Study Results

No Results Posted as of Feb 22, 2019