Coronary Anatomy Study and Times Since the Onset of Acute Myocardial Infarction Symptoms in Women Until the Opening of the Artery (TAPAC Study)
Study Details
Study Description
Brief Summary
TAPAC study is an an investigator-driven, observational, prospective,cohort aimed at evaluating differences between men and women in patients undergoing primary angioplasty : hospital medical care, successful markers myocardial reperfusion and the anatomical substrate by describing the underlying coronary anatomy will be compared.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
TAPAC study is an an investigator-driven, observational, prospective,cohort aimed at evaluating differences between men and women in patients undergoing primary angioplasty : hospital medical care, successful markers myocardial reperfusion and the anatomical substrate by describing the underlying coronary anatomy will be compared.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Women patients Women patients |
Other: Non intervention
Non intervention
|
| Men patients Men patients |
Other: Non intervention
Non intervention
|
Outcome Measures
Primary Outcome Measures
- Door-to-balloon time in patients [90 minutes]
Door-to-balloon time in patients
- Door-to-needle time in patients [90 minutes]
Door-to-balloon time in patients
- Time from onset of chest pain to first medical care [24 hours]
Time from onset of chest pain to first medical care
- Time from onset of chest pain to arrival Cath Lab [24 hours]
Time from onset of chest pain to arrival Cath Lab
- Time from onset of chest pain to artery opening [24 hours]
Time from onset of chest pain to artery opening
- Markers successful myocardial reperfusion by angiography [First 90 min after reperfusion.]
ST segment resolution 90 minutes post-PCI (Percutaneous Coronary Intervention)
- Markers successful myocardial reperfusion by angiography [First 90 min after reperfusion.]
Final TIMI (Thrombolysis in Myocardial Infarction) flow grade
- Markers successful myocardial reperfusion by angiography [First 90 min after reperfusion.]
Final TIMI blush grade
- Underlying coronary anatomy assessment [24 hours]
Final TIMI Thrombus grade
- Underlying coronary anatomy assessment [24 hours]
Degree of difuse disease
- Underlying coronary anatomy assessment [24 hours]
Number of vessels involve
- Underlying coronary anatomy assessment [24 hours]
Percentage of Ventricular Ejection Fraction
- Underlying coronary anatomy assessment [24 hours]
Presence of significant Left Main disease
- Underlying coronary anatomy assessment [24 hours]
Degree of distal embolization
Secondary Outcome Measures
- Major adverse cardiac events (MACE) [Hospital discharge and expected average of 1 week, one year follow-up]
MACE rate during hospitalization, defined as death, non-fatal myocardial rupture, or appearance or worsening of heart failure during the hospitalization period and after 1 year of follow-up
Eligibility Criteria
Criteria
Inclusion Criteria:
Patients with:
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Aged 18 years or over.
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AMI (Acute Mycardial Infarction ) with ST segment elevation and indication of primary angioplasty in whom at least one diagnostic procedure with coronary angiography is performed.
Exclusion Criteria:
Patients with:
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Life expectancy of less than one year.
-
Previous AMI.
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Previous coronary revascularization.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hospital Universitari Vall d'Hebron | Barcelona | Spain | 08035 |
Sponsors and Collaborators
- Hospital Universitari Vall d'Hebron Research Institute
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- 2. World Health Organization.The European Health Report2012: Chartingthe Wayto Well-being. Copenhagen, Denmark: World Health Organization Regional Office for Europe;2012
- Dégano IR, Salomaa V, Veronesi G, Ferriéres J, Kirchberger I, Laks T, Havulinna AS, Ruidavets JB, Ferrario MM, Meisinger C, Elosua R, Marrugat J; Acute Myocardial Infarction Trends in Europe (AMITIE) Study Investigators. Twenty-five-year trends in myocardial infarction attack and mortality rates, and case-fatality, in six European populations. Heart. 2015 Sep;101(17):1413-21. doi: 10.1136/heartjnl-2014-307310. Epub 2015 Apr 8. Erratum in: Heart. 2018 Aug;104(16):e2.
- Garcia-Dorado D, Garcia del Blanco B. Door-to-balloon time and mortality. N Engl J Med. 2014 Jan 9;370(2):179. doi: 10.1056/NEJMc1313113.
- Pancholy SB, Shantha GP, Patel T, Cheskin LJ. Sex differences in short-term and long-term all-cause mortality among patients with ST-segment elevation myocardial infarction treated by primary percutaneous intervention: a meta-analysis. JAMA Intern Med. 2014 Nov;174(11):1822-30. doi: 10.1001/jamainternmed.2014.4762. Review.
- Writing Group Members, Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, Das SR, de Ferranti S, Després JP, Fullerton HJ, Howard VJ, Huffman MD, Isasi CR, Jiménez MC, Judd SE, Kissela BM, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Magid DJ, McGuire DK, Mohler ER 3rd, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Rosamond W, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Woo D, Yeh RW, Turner MB; American Heart Association Statistics Committee; Stroke Statistics Subcommittee. Executive Summary: Heart Disease and Stroke Statistics--2016 Update: A Report From the American Heart Association. Circulation. 2016 Jan 26;133(4):447-54. doi: 10.1161/CIR.0000000000000366.
- TAPAC study