MIR: Myocardial Infarction Registry
Study Details
Study Description
Brief Summary
The single-center MIR-registry was created to assess real-world prevalence, demographic characteristics and management of patients with acute coronary syndrome presenting in the emergency department (ED) of University of Heidelberg.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
To conduct a comprehensive characterization of patients with symptoms of acute coronary syndrome or elevated troponin levels. Records include clinical routine parameters, there will be an expansion involving the collection of blood samples for the analysis of novel laboratory-based and omics-based biomarkers. The ACS registry is monothetically managed by the Department of Internal Medicine III at Heidelberg University Hospital and is intended to serve as a basis for further clinical diagnostic and outcome studies. The blood samples will serve as the foundation for a comprehensive analysis of established and novel laboratory-based markers, as well as omics-based biomarkers (miRNA, metabolomics, and proteomics). Follow-up was performed via review of medical reports, phone calls and postal queries. The outcome parameters comprised rates for all-cause mortality, non-hemorrhagic stroke, myocardial infarction, and hospitalization for any cause.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| MIR (Myocardial Infarction Registry) All patients presenting to the Emergency Department with suspected acute coronary syndrome |
Other: no intervention is intended.
no intervention is intended.
|
Outcome Measures
Primary Outcome Measures
- all-cause mortality [12 months]
all-cause mortality during follow-up
Secondary Outcome Measures
- myocardial infarction [12 months]
myocardial infarction during follow-up
- stroke [12 months]
stroke during follow-up
- Rehospitalization [12 months]
Rehospitalization during follow-up
Eligibility Criteria
Criteria
Inclusion Criteria:
The study will include consecutive patients who present to the cardiology emergency department at Heidelberg University Hospital with symptoms of acute coronary syndrome or a troponin increase (hs-TnT >14 ng/L). Additional inclusion criteria are a minimum age of 18 years and providing informed consent through written consent to participate in the study.
The following medical conditions are intended to be distinguished from one another:
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Acute myocardial infarction
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Unstable angina pectoris
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Myocarditis
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Heart failure
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Cardiomyopathies
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Pulmonary embolism
-
Renal insufficiency
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Supraventricular and ventricular tachycardias
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Hypertensive crisis
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Non-cardiac chest pain
Exclusion Criteria:
Exclusion criteria are defined according to GCP (Good Clinical Practice), i.e., mental illnesses/dementia (lack of capacity to provide informed consent), pregnancy/breastfeeding, as well as acute conditions requiring immediate treatment (e.g., cardiogenic shock).
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University Hospital of Heidelberg | Heidelberg | Baden-Württemberg | Germany | 69120 |
Sponsors and Collaborators
- University Hospital Heidelberg
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- MIR