Choroidal Change on OCTA in Eyes With High Myopia
Study Details
Study Description
Brief Summary
Myopia is a global healthy concern, especially the high myopia and pathological myopia among Asian populations. However, its mechanism still remains largely unclear. Recent findings suggested choroidal changes might be related to the development of myopia. This study is to useOCT angiography (OCT-A) to investigate parapapillary choroidal microvasculature change in myopic eyes, and try to find the cause-and-effect relationship between choroidal change and the development of myopia.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: Group 1/Control Spherical equivalent: -2.00~+2.00 D |
Device: Optic coherence tomography angiography (OCTA)
Using non-invasive, repeatable, mature device OCTA to obtain choroidal angio-map
|
Experimental: Group 1/Myopia Spherical equivalent: -3.00~-6.00 D |
Device: Optic coherence tomography angiography (OCTA)
Using non-invasive, repeatable, mature device OCTA to obtain choroidal angio-map
|
Experimental: Group 3/High Spherical equivalent: -6.00~-10.00 D |
Device: Optic coherence tomography angiography (OCTA)
Using non-invasive, repeatable, mature device OCTA to obtain choroidal angio-map
|
Experimental: Group 4/Super High Spherical equivalent: <-10.00 |
Device: Optic coherence tomography angiography (OCTA)
Using non-invasive, repeatable, mature device OCTA to obtain choroidal angio-map
|
Outcome Measures
Primary Outcome Measures
- Parapapillary choroidal microvasculature void (MvV) area [changes of MvV area from at 10 years]
area of parapapillary choroidal microvasculature void on OCTA images
- Parapapillary choroidal microvasculature void (MvV) area [difference of MvV area in each group at baseline]
area of parapapillary choroidal microvasculature void on OCTA images
- Parapapillary choroidal microvasculature void (MvV) area [changes of MvV area at 1 years]
area of parapapillary choroidal microvasculature void on OCTA images
- Parapapillary choroidal microvasculature void (MvV) area [changes of MvV area at 3 years]
area of parapapillary choroidal microvasculature void on OCTA images
- Parapapillary choroidal microvasculature void (MvV) area [changes of MvV area at 5 years]
area of parapapillary choroidal microvasculature void on OCTA images
Secondary Outcome Measures
- MvV number [baseline]
number of choroidal MvV with certain size
- Correlation coefficient between choroidal MvV and refractive power [baseline]
Correlation coefficient between choroidal MvV and refractive power
- Correlation coefficient between choroidal MvV and PPA area [baseline]
Correlation coefficient between choroidal MvV and parapapillary atrophy beta area
- Correlation coefficient between choroidal MvV and choroid thickness [baseline]
Correlation coefficient between choroidal MvV and choroid thickness
- Correlation coefficient between choroidal MvV and RNFL thickness [baseline]
Correlation coefficient between choroidal MvV and RNFL thickness
- Correlation coefficient between choroidal MvV and Axial length [baseline]
Correlation coefficient between choroidal MvV and Axial length
- Correlation coefficient between choroidal MvV and retinal parapapillary perfusion [baseline]
Correlation coefficient between choroidal MvV and retinal parapapillary perfusion on OCTA images.
- Correlation coefficient between choroidal MvV and Macular perfusion [baseline]
Correlation coefficient between choroidal MvV and Macular perfusion on OCTA images, Retinal parapapillary perfusion with OCTA.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Spherical equivalent measurement can be included in above 4 groups
-
Willing to be followed up in the future 10 years
Exclusion Criteria:
-
Deny to sign the patient consent, or deny to be followed
-
Evidence of cardiac, or diabetic, or CNS disease.
-
Clinically diagnosed with retinal or choroidal disease
-
Glucoma
-
Cataract or corneal disease that influence the quality of fundus OCTA image
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | First Affiliated Hospital of Nanjing Medical University | Nanjing | Jiangsu | China | 210029 |
Sponsors and Collaborators
- The First Affiliated Hospital with Nanjing Medical University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- OCTAPPA