Cyanobacteria Allergy in Lake Kineret

Sponsor

Meir Medical Center (Other)

Overall Status

Unknown status

CT.gov ID

NCT01693198

Collaborator

Yigal Allon Kinneret Limnological Laboratory (Other)

200

Enrollment

Location

Duration (Months)

8.3

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

People swimming or surfing in lake Kineret , sometimes complain of nasal stuffiness , sneezing and itching .Typically, it happens during or immediately after contact with the lake's water . The symptoms are compatible with immediate allergic reaction. Previous reports suggested a connection between similar symptoms and contact with different cyanobacteria (living in fresh water lakes). In this study we intend to prove the mechanism of these reactions. To prove the exact allergen that causes allergic rhinitis allergists perform skin tests with different suspected allergens. Likewise, we would like to perform skin tests to different proteins extracted from cyanobacteria collected in lake Kineret.

Condition or Disease	Intervention/Treatment	Phase
Nasal Stuffiness Sneezing Itching	Procedure: Skin test with sterile extracts of different cyanobacteria	N/A

Study Design

Study Type:

Interventional

Anticipated Enrollment :

200 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Diagnostic

Official Title:

Cyanobacteria Allergy in Lake Kineret

Study Start Date :

Nov 1, 2012

Anticipated Primary Completion Date :

Nov 1, 2014

Anticipated Study Completion Date :

Nov 1, 2014

Outcome Measures

Primary Outcome Measures

Reproducibility of skin test to cyanobacteria [Immediately after performing the test (15 minutes)]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

age above 18
exposed to Lake Keneret water by swiming or sirfing

Exclusion Criteria:

age under 18
pregnancy

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Meir medical center	Kfar-Saba		Israel

Sponsors and Collaborators

Meir Medical Center
Yigal Allon Kinneret Limnological Laboratory

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

1. Carmichael W. A world overview-One-hundred-twentyseven years of research on toxic cyanobacteria-Where do we go from here? Adv Exp Med Biol 2008;619:105-125 2. Petrus M, Culerrier R, Campistron M, Barre A, Rouge P. First case report of anaphylaxis to spirulin: identification of phycocyanin as responsible allergen. AL L ERGY (AllergyNet) 2010; 65 : 924-932N 3. Torokne A, Palovics A, and Bankine M. Allergenic (sensitization, skin and eye Irritation).Effects of freshwater Cyanobacteria-experimental evidence. Environ Toxicol 2001; 16: 512-516 4.Alster, A., Kaplan-Levy, R., Sukenik, A. & Zohary, T. Morphology and phylogeny of a non-toxic invasive Cylindrospermopsis raciborskii from a Mediterranean Lake. Hydrobiologia 2010; 639, 115-128. 5.Banker, R., Carmeli, S., Hadas, O., Teltsch, B., Porat, R. & Sukenik, A. Identification of cylindrospermopsin in Aphanizomenon ovalisporum (Cyanophyceae) isolated from Lake Kinneret, Israel. Journal of Phycology 1997; 33, 613-616. 6.Hadas, O., Pinkas, R., Malinsky-Rushansky, N., Nishri, A., Kaplan, A., Rimmer, A. & Sukenik, A. Appearance and establishment of diazotrophic cyanobacteria in Lake Kinneret, Israel. Freshwater Biology 2012; 57, 1214-1227. 7. Bernstein JA, Ghosh D, Levin LS, Zheng S, Carmichael W, Lummus Z, Bernstein IL. Cyanobacteria: an unrecognized ubiquitous sensitizing allergen? Allergy Asthma Proc. 2011;32:106-110 8.Törökné, A., Asztalos, M., Bánkiné, M., Bickel, H., Borbély, G., Carmeli, S., Codd, G.A., Fastner, J., Huang, Q., Humpage, A., Metcalf, J.S., Rábai, E., Sukenik, A., Surányi, G., Vasas, G. & Weiszfeiler, V. Interlaboratory comparison trial on cylindrospermopsin measurement. Analytical Biochemistry 2004; 332, 280-284. 9.Lawton, L.A., Edwards, C. & Codd, G.A. Extraction and high-performance liquid chromatographic method for the determination of microcystins in raw and treated waters. Analyst 1994; 119, 1525-1530

Responsible Party:

Ronit Confino-Cohen, MD, Meir Medical Center

ClinicalTrials.gov Identifier:

NCT01693198

Other Study ID Numbers:

0172-12-MMC

First Posted:

Sep 26, 2012

Last Update Posted:

Sep 26, 2012

Last Verified:

Sep 1, 2012

Keywords provided by Ronit Confino-Cohen, MD, Meir Medical Center

allergy

cyanobacteria

sweet water swimming

Additional relevant MeSH terms:

Hypersensitivity

Sneezing

Study Results

No Results Posted as of Sep 26, 2012