The National Myelodysplastic Syndromes (MDS) Study
Sponsor
National Heart, Lung, and Blood Institute (NHLBI) (NIH)
Overall Status
Recruiting
CT.gov ID
NCT02775383
Collaborator
National Cancer Institute (NCI) (NIH)
3,500
281
105
12.5
0.1
Study Details
Study Description
Brief Summary
Multi-center study enrolling patients suspected or newly diagnosed with myelodysplastic syndromes (MDS), myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) overlap disorder, or idiopathic cytopenia of undetermined significance (ICUS). Participants will be followed long term. Clinical data, blood, and tissue samples will be collected to establish a biorepository to facilitate the study of the natural history of MDS.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Multi-center, prospective cohort study enrolling patients from centers in the National Cancer Institute (NCI) National Clinical Trials Network (NCTN) and NCI Community Oncology Research Program (NCORP). The accrual period is 5+ years. After central pathology review of registered participants, approximately 2,000 cases of MDS or MDS/MPN overlap disorders, and 500 cases of ICUS will be identified for the longitudinal study cohort and up to 1000 cases will be identified for the cross-sectional cohort. No more than 3500 total participants will be registered. Participants in the longitudinal cohort may be followed for life.
The goal of the National MDS Study is to establish a publicly available resource to facilitate the study of MDS natural history. This will be accomplished through: 1) Creation of a multi-institutional, longitudinal collection of consistently processed and clinically well-annotated blood and tissue specimens collected prospectively from participants with MDS and participants with idiopathic cytopenia of undetermined significance (ICUS); and 2) Support for investigator-initiated studies of MDS that will have high-impact for MDS patients, including basic science, clinical, health outcomes and epidemiological research.
Study Design
Study Type:
Observational
Anticipated Enrollment
:
3500 participants
Observational Model:
Cohort
Time Perspective:
Prospective
Official Title:
The National Myelodysplastic Syndromes Natural History Study
Study Start Date
:
Apr 1, 2016
Anticipated Primary Completion Date
:
Jan 1, 2025
Anticipated Study Completion Date
:
Jan 1, 2025
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Longitudinal Participants with MDS, MDS/MPN overlap disorder, AML <30% blasts without core binding factor or acute promyelocytic leukemia, ICUS, or at risk based on select karyotypic or genetic abnormalities |
Other: Therapeutic
Observational Study
|
| Cross-sectional Participants who do not have MDS, MDS/MPN overlap disorder, or ICUS and have the baseline visit only |
Other: Therapeutic
Observational Study
|
Outcome Measures
Primary Outcome Measures
- Number of patients dying [Through study completion, an average of 3 years]
Deaths will be reported on study case report forms
Secondary Outcome Measures
- Number of participants progressing to Acute Myeloid Leukemia (AML) [Through study completion, an average of 3 years]
Progression to AML will be reported on study case report forms
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
Suspected (e.g., persistent unexplained cytopenia, circulating peripheral blasts etc.) MDS or MDS/MPN overlap disorders and undergoing diagnostic work-up with planned bone marrow assessments, or diagnosed with de novo or therapy-related MDS within 12 months of enrollment per the World Health Organization (WHO) criteria1 and undergoing clinical evaluation and planned bone marrow assessments to confirm MDS or to evaluate disease status
-
Bone marrow aspirate expected to be performed within 1 week of registration, and in all cases must be performed no later than 4 weeks after enrollment
-
Age 18 or older
-
If anemic without prior MDS diagnosis, B12 level, serum folate, mean corpuscular volume (MCV), red cell distribution width (RDW), ferritin, and iron studies (Iron, total iron-binding capacity (TIBC) test, and percent saturation) must be performed within prior 6 months.
Exclusion Criteria:
-
Prior treatment for MDS at entry and through the time of the entry bone marrow aspirate
-
Treatment with hematopoietic growth factors in prior 6 months
-
Diagnosis of a solid tumor or hematologic malignancy within two years prior to enrollment except for in situ cancer of the skin (basal or squamous cell), cervix, bladder, breast, or prostate
-
Treatment with radiation therapy in the two years prior to registration
-
Non-hormonal treatment for malignancy within the two years prior to registration
-
Established hereditary bone marrow failure syndrome
-
Known primary diagnosis of aplastic anemia, classical paroxysmal nocturnal hemoglobinuria, amegakaryocytic thrombocytopenic purpura, or large granular lymphocyte leukemia
-
Enrolled in the Connect® MDS/AML Disease Registry (NCT01688011)
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Kaiser Permanente-Anaheim | Anaheim | California | United States | 92806 |
| 2 | Kaiser Permanente-Baldwin Park | Baldwin Park | California | United States | 91706 |
| 3 | Kaiser Permanente-Bellflower | Bellflower | California | United States | 90706 |
| 4 | Kaiser Permanente-Fontana | Fontana | California | United States | 92335 |
| 5 | Kaiser Permanente - Harbor City | Harbor City | California | United States | 90710 |
| 6 | Kaiser Permanente-Irvine | Irvine | California | United States | 92618 |
| 7 | Tibor Rubin VA Medical Center | Long Beach | California | United States | 90822 |
| 8 | Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | United States | 90027 |
| 9 | Kaiser Permanente-Cadillac | Los Angeles | California | United States | 90034 |
| 10 | Va Palo Alto Health Care System | Palo Alto | California | United States | 94304 |
| 11 | Kaiser Permanente - Panorama City | Panorama City | California | United States | 91402 |
| 12 | Eisenhower Medical Center | Rancho Mirage | California | United States | 92270 |
| 13 | Kaiser Permanente-Riverside | Riverside | California | United States | 92505 |
| 14 | Kaiser Permanente-San Diego Zion | San Diego | California | United States | 92120 |
| 15 | Veterans Affairs Medical Center - San Francisco | San Francisco | California | United States | 94121 |
| 16 | Kaiser Permanente-San Marcos | San Marcos | California | United States | 92078 |
| 17 | Kaiser Permanente-Woodland Hills | Woodland Hills | California | United States | 91367 |
| 18 | Rocky Mountain Regional VA Medical Center | Aurora | Colorado | United States | 80045 |
| 19 | Smilow Cancer Center/Yale-New Haven Hospital | New Haven | Connecticut | United States | 06511 |
| 20 | Yale University | New Haven | Connecticut | United States | 06520 |
| 21 | Veterans Affairs Connecticut Healthcare System-West Haven Campus | West Haven | Connecticut | United States | 06516 |
| 22 | Helen F Graham Cancer Center | Newark | Delaware | United States | 19713 |
| 23 | Medical Oncology Hematology Consultants PA | Newark | Delaware | United States | 19713 |
| 24 | Regional Hematology and Oncology PA | Newark | Delaware | United States | 19713 |
| 25 | Christiana Care Health System-Christiana Hospital | Newark | Delaware | United States | 19718 |
| 26 | Baptist MD Anderson Cancer Center | Jacksonville | Florida | United States | 32207 |
| 27 | Mayo Clinic in Florida | Jacksonville | Florida | United States | 32224 |
| 28 | Lakeland Regional Health Hollis Cancer Center | Lakeland | Florida | United States | 33805 |
| 29 | Moffitt Cancer Center | Tampa | Florida | United States | 33612 |
| 30 | Indian River Medical Center | Vero Beach | Florida | United States | 32960 |
| 31 | Northside Hospital | Atlanta | Georgia | United States | 30342 |
| 32 | Augusta University Medical Center | Augusta | Georgia | United States | 30912 |
| 33 | Atlanta VA Medical Center | Decatur | Georgia | United States | 30033 |
| 34 | Northside Hospital - Duluth | Duluth | Georgia | United States | 30096 |
| 35 | Northeast Georgia Medical Center-Gainesville | Gainesville | Georgia | United States | 30501 |
| 36 | Northside Hospital - Gwinnett | Lawrenceville | Georgia | United States | 30046 |
| 37 | Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | United States | 31405 |
| 38 | Suburban Hematology Oncology Associates - Snellville | Snellville | Georgia | United States | 30078 |
| 39 | Pali Momi Medical Center | 'Aiea | Hawaii | United States | 96701 |
| 40 | Queen's Cancer Center - Pearlridge | 'Aiea | Hawaii | United States | 96701 |
| 41 | Queen's Cancer Center - POB I | Honolulu | Hawaii | United States | 96813 |
| 42 | Queen's Medical Center | Honolulu | Hawaii | United States | 96813 |
| 43 | Straub Clinic and Hospital | Honolulu | Hawaii | United States | 96813 |
| 44 | University of Hawaii Cancer Center | Honolulu | Hawaii | United States | 96813 |
| 45 | Hawaii Cancer Care Inc-POB II | Honolulu | Hawaii | United States | 96817 |
| 46 | OnCare Hawaii - Liliha | Honolulu | Hawaii | United States | 96817 |
| 47 | Queen's Cancer Center - Kuakini | Honolulu | Hawaii | United States | 96817 |
| 48 | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | United States | 96826 |
| 49 | Kootenai Medical Center | Coeur d'Alene | Idaho | United States | 83814 |
| 50 | Kootenai Cancer Center | Post Falls | Idaho | United States | 83854 |
| 51 | Kootenai Cancer Clinic | Sandpoint | Idaho | United States | 83864 |
| 52 | Illinois CancerCare - Bloomington | Bloomington | Illinois | United States | 61704 |
| 53 | Memorial Hospital of Carbondale | Carbondale | Illinois | United States | 62901 |
| 54 | SIH Cancer Institute | Carterville | Illinois | United States | 62918 |
| 55 | Centralia Oncology Clinic | Centralia | Illinois | United States | 62801 |
| 56 | Carle on Vermilion | Danville | Illinois | United States | 61832 |
| 57 | Decatur Memorial Hospital | Decatur | Illinois | United States | 62522 |
| 58 | Cancer Care Specialists of Central Illinois - Decatur | Decatur | Illinois | United States | 62568 |
| 59 | Carle Physician Group-Effingham | Effingham | Illinois | United States | 62401 |
| 60 | Crossroads Cancer Center | Effingham | Illinois | United States | 62401 |
| 61 | AMITA Health Alexian Brothers Medical Center | Elk Grove Village | Illinois | United States | 60007 |
| 62 | Illinois CancerCare - Galesburg | Galesburg | Illinois | United States | 61401 |
| 63 | AMITA Health Cancer Institute and Outpatient Center | Hinsdale | Illinois | United States | 60521 |
| 64 | Presence Saint Mary's Hospital | Kankakee | Illinois | United States | 60901 |
| 65 | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | United States | 61938 |
| 66 | Cancer Care Specialists of O'Fallon | O'Fallon | Illinois | United States | 62269 |
| 67 | Illinois CancerCare - Peoria | Peoria | Illinois | United States | 61615 |
| 68 | Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 69 | Mercy Hospital | Cedar Rapids | Iowa | United States | 52403 |
| 70 | Oncology Associates at Mercy Medical Center | Cedar Rapids | Iowa | United States | 52403 |
| 71 | Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa | United States | 50325 |
| 72 | Mercy Cancer Center-West Lakes | Clive | Iowa | United States | 50325 |
| 73 | Greater Regional Medical Center | Creston | Iowa | United States | 50801 |
| 74 | Iowa Methodist Medical Center | Des Moines | Iowa | United States | 50309 |
| 75 | Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa | United States | 50314 |
| 76 | Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa | United States | 50314 |
| 77 | Mercy Medical Center - Des Moines | Des Moines | Iowa | United States | 50314 |
| 78 | Mercy Medical Center-West Lakes | West Des Moines | Iowa | United States | 50266 |
| 79 | Cancer Center of Kansas - Chanute | Chanute | Kansas | United States | 66720 |
| 80 | Cancer Center of Kansas - Dodge City | Dodge City | Kansas | United States | 67801 |
| 81 | Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas | United States | 66701 |
| 82 | Cancer Center of Kansas-Independence | Independence | Kansas | United States | 67301 |
| 83 | Cancer Center of Kansas-Kingman | Kingman | Kansas | United States | 67068 |
| 84 | Lawrence Memorial Hospital | Lawrence | Kansas | United States | 66044 |
| 85 | Kansas Institute of Medicine Cancer and Blood Center | Lenexa | Kansas | United States | 66219 |
| 86 | Cancer Center of Kansas - Liberal | Liberal | Kansas | United States | 67901 |
| 87 | Cancer Center of Kansas - Newton | Newton | Kansas | United States | 67114 |
| 88 | Cancer Center of Kansas - Parsons | Parsons | Kansas | United States | 67357 |
| 89 | Cancer Center of Kansas - Pratt | Pratt | Kansas | United States | 67124 |
| 90 | Cancer Center of Kansas - Salina | Salina | Kansas | United States | 67401 |
| 91 | Cancer Center of Kansas - Wellington | Wellington | Kansas | United States | 67152 |
| 92 | Associates In Womens Health | Wichita | Kansas | United States | 67208 |
| 93 | Cancer Center of Kansas - Wichita Medical Arts Tower | Wichita | Kansas | United States | 67208 |
| 94 | Cancer Center of Kansas - Wichita | Wichita | Kansas | United States | 67208 |
| 95 | Ascension Via Christi Hospitals Wichita | Wichita | Kansas | United States | 67218 |
| 96 | Cancer Center of Kansas - Winfield | Winfield | Kansas | United States | 67156 |
| 97 | Harold Alfond Center for Cancer Care | Augusta | Maine | United States | 04330 |
| 98 | Waldo County General Hospital | Belfast | Maine | United States | 04915 |
| 99 | MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford | Biddeford | Maine | United States | 04005 |
| 100 | Stephens Memorial Hospital | Norway | Maine | United States | 04268 |
| 101 | Penobscot Bay Medical Center | Rockport | Maine | United States | 04856 |
| 102 | MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford | Sanford | Maine | United States | 04073 |
| 103 | Maine Medical Partners-South Portland | South Portland | Maine | United States | 01406 |
| 104 | York Hospital | York | Maine | United States | 03909 |
| 105 | Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | United States | 21231 |
| 106 | UM Upper Chesapeake Medical Center | Bel Air | Maryland | United States | 21014 |
| 107 | Walter Reed National Military Medical Center | Bethesda | Maryland | United States | 20889 |
| 108 | UMass Memorial Medical Center - University Campus | Worcester | Massachusetts | United States | 01655 |
| 109 | Saint Joseph Mercy Hospital | Ann Arbor | Michigan | United States | 48106 |
| 110 | IHA Hematology Oncology Consultants-Brighton | Brighton | Michigan | United States | 48114 |
| 111 | Saint Joseph Mercy Brighton | Brighton | Michigan | United States | 48114 |
| 112 | IHA Hematology Oncology Consultants-Canton | Canton | Michigan | United States | 48188 |
| 113 | Saint Joseph Mercy Canton | Canton | Michigan | United States | 48188 |
| 114 | IHA Hematology Oncology Consultants-Chelsea | Chelsea | Michigan | United States | 48118 |
| 115 | Saint Joseph Mercy Chelsea | Chelsea | Michigan | United States | 48118 |
| 116 | Beaumont Hospital - Dearborn | Dearborn | Michigan | United States | 48124 |
| 117 | Michigan State University Clinical Center | East Lansing | Michigan | United States | 48824 |
| 118 | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | United States | 49503 |
| 119 | West Michigan Cancer Center | Kalamazoo | Michigan | United States | 22787 |
| 120 | Spectrum Health Reed City Hospital | Reed City | Michigan | United States | 49677 |
| 121 | William Beaumont Hospital-Royal Oak | Royal Oak | Michigan | United States | 48073 |
| 122 | Ascension Saint Mary's Hospital | Saginaw | Michigan | United States | 48601 |
| 123 | Ascension Providence Hospitals - Southfield | Southfield | Michigan | United States | 48075 |
| 124 | William Beaumont Hospital - Troy | Troy | Michigan | United States | 48073 |
| 125 | Metro Health Hospital | Wyoming | Michigan | United States | 49519 |
| 126 | IHA Hematology Oncology Consultants-Ann Arbor | Ypsilanti | Michigan | United States | 48197 |
| 127 | Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | United States | 56601 |
| 128 | Mercy Hospital | Coon Rapids | Minnesota | United States | 55433 |
| 129 | Saint Luke's Hospital of Duluth | Duluth | Minnesota | United States | 55802 |
| 130 | Essentia Health Cancer Center | Duluth | Minnesota | United States | 55805 |
| 131 | Essentia Health Saint Mary's Medical Center | Duluth | Minnesota | United States | 55805 |
| 132 | Miller-Dwan Hospital | Duluth | Minnesota | United States | 55805 |
| 133 | Fairview Southdale Hospital | Edina | Minnesota | United States | 55435 |
| 134 | Unity Hospital | Fridley | Minnesota | United States | 55432 |
| 135 | Abbott-Northwestern Hospital | Minneapolis | Minnesota | United States | 55407 |
| 136 | Minneapolis VA Medical Center | Minneapolis | Minnesota | United States | 55417 |
| 137 | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | United States | 55416 |
| 138 | United Hospital | Saint Paul | Minnesota | United States | 55102 |
| 139 | Saint Francis Regional Medical Center | Shakopee | Minnesota | United States | 55739 |
| 140 | Saint Francis Medical Center | Cape Girardeau | Missouri | United States | 63703 |
| 141 | Capital Region Southwest Campus | Jefferson City | Missouri | United States | 65109 |
| 142 | Kansas City Veterans Affairs Medical Center | Kansas City | Missouri | United States | 64128 |
| 143 | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | United States | 65401 |
| 144 | Mercy Clinic - Rolla - Cancer and Hematology | Rolla | Missouri | United States | 65401 |
| 145 | Heartland Regional Medical Center | Saint Joseph | Missouri | United States | 64506 |
| 146 | Mercy Hospital Springfield | Springfield | Missouri | United States | 65804 |
| 147 | CoxHealth South Hospital | Springfield | Missouri | United States | 65807 |
| 148 | Community Hospital of Anaconda | Anaconda | Montana | United States | 59711 |
| 149 | Bozeman Deaconess Hospital | Bozeman | Montana | United States | 59715 |
| 150 | Benefis Healthcare-Sletten Cancer Institute | Great Falls | Montana | United States | 59406 |
| 151 | CHI Health Saint Francis | Grand Island | Nebraska | United States | 68803 |
| 152 | OptumCare Cancer Care at Seven Hills | Henderson | Nevada | United States | 89052 |
| 153 | OptumCare Cancer Care at Oakey | Las Vegas | Nevada | United States | 89102 |
| 154 | Hope Cancer Care of Nevada | Las Vegas | Nevada | United States | 89103 |
| 155 | OptumCare Cancer Care at Mountainview | Las Vegas | Nevada | United States | 89128 |
| 156 | Alliance for Childhood Diseases/Cure 4 the Kids Foundation | Las Vegas | Nevada | United States | 89135 |
| 157 | OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 158 | Veterans Administration New Jersey Health Care System | East Orange | New Jersey | United States | 07018-1095 |
| 159 | Inspira Medical Center Woodbury | Woodbury | New Jersey | United States | 08096 |
| 160 | University of New Mexico Cancer Center | Albuquerque | New Mexico | United States | 87106 |
| 161 | Memorial Medical Center-Las Cruces | Las Cruces | New Mexico | United States | 88011 |
| 162 | Montefiore Medical Center - Einstein Campus | Bronx | New York | United States | 10461 |
| 163 | Montefiore Medical Center - Moses Campus | Bronx | New York | United States | 10467 |
| 164 | James J Peters VA Medical Center | Bronx | New York | United States | 10468 |
| 165 | Maimonides Medical Center | Brooklyn | New York | United States | 11219 |
| 166 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263 |
| 167 | Arnot Ogden Medical Center/Falck Cancer Center | Elmira | New York | United States | 14905 |
| 168 | Glens Falls Hospital | Glens Falls | New York | United States | 12801 |
| 169 | North Shore University Hospital | Lake Success | New York | United States | 11042 |
| 170 | Northwell Health/Center for Advanced Medicine | Lake Success | New York | United States | 11042 |
| 171 | Long Island Jewish Medical Center | New Hyde Park | New York | United States | 11040 |
| 172 | Phelps Memorial Hospital Center | Sleepy Hollow | New York | United States | 10591 |
| 173 | Mission Hospital | Asheville | North Carolina | United States | 28801 |
| 174 | Durham VA Medical Center | Durham | North Carolina | United States | 27705 |
| 175 | Sanford Bismarck Medical Center | Bismarck | North Dakota | United States | 58501 |
| 176 | Sanford Clinic North-Fargo | Fargo | North Dakota | United States | 58102 |
| 177 | Sanford Broadway Medical Center | Fargo | North Dakota | United States | 58122 |
| 178 | Sanford Roger Maris Cancer Center | Fargo | North Dakota | United States | 58122 |
| 179 | Cleveland Clinic Akron General | Akron | Ohio | United States | 44307 |
| 180 | MetroHealth Medical Center | Cleveland | Ohio | United States | 44109 |
| 181 | Cleveland Clinic Foundation | Cleveland | Ohio | United States | 44195 |
| 182 | Cleveland Clinic Cancer Center/Fairview Hospital | Fairview | Ohio | United States | 44111 |
| 183 | Cleveland Clinic Cancer Center Independence | Independence | Ohio | United States | 44131 |
| 184 | Cleveland Clinic Cancer Center Mansfield | Mansfield | Ohio | United States | 44906 |
| 185 | Hillcrest Hospital Cancer Center | Mayfield Heights | Ohio | United States | 44124 |
| 186 | North Coast Cancer Care | Sandusky | Ohio | United States | 44870 |
| 187 | Cleveland Clinic Wooster Family Health and Surgery Center | Wooster | Ohio | United States | 44691 |
| 188 | Cancer Centers of Southwest Oklahoma Research | Lawton | Oklahoma | United States | 73505 |
| 189 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 190 | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | United States | 73120 |
| 191 | Kaiser Permanente Northwest | Portland | Oregon | United States | 97227 |
| 192 | Oregon Health & Science University | Portland | Oregon | United States | 97239 |
| 193 | Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | United States | 18103 |
| 194 | Lehigh Valley Hospital-Muhlenberg | Bethlehem | Pennsylvania | United States | 18017 |
| 195 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17821 |
| 196 | Easton Hospital | Easton | Pennsylvania | United States | 18042 |
| 197 | Ephrata Cancer Center | Ephrata | Pennsylvania | United States | 17522 |
| 198 | Adams Cancer Center | Gettysburg | Pennsylvania | United States | 17325 |
| 199 | Geisinger Medical Center - Cancer Center Hazleton | Hazleton | Pennsylvania | United States | 18201 |
| 200 | Sechler Family Cancer Center | Lebanon | Pennsylvania | United States | 17042 |
| 201 | Geisinger Medical Oncology - Lewisburg | Lewisburg | Pennsylvania | United States | 17837 |
| 202 | University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania | United States | 19104 |
| 203 | Phoenixville Hospital | Phoenixville | Pennsylvania | United States | 19460 |
| 204 | Pottstown Hospital | Pottstown | Pennsylvania | United States | 19464 |
| 205 | Geisinger Cancer Services - Pottsville | Pottsville | Pennsylvania | United States | 17901 |
| 206 | Penn State Health Saint Joseph Medical Center | Reading | Pennsylvania | United States | 19605 |
| 207 | Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | United States | 18711 |
| 208 | UPMC Susquehanna | Williamsport | Pennsylvania | United States | 17701 |
| 209 | WellSpan Health-York Hospital | York | Pennsylvania | United States | 17401 |
| 210 | Ralph H Johnson VA Medical Center | Charleston | South Carolina | United States | 29401 |
| 211 | Prisma Health Cancer Institute - Easley | Easley | South Carolina | United States | 29640 |
| 212 | Saint Francis Hospital | Greenville | South Carolina | United States | 29601 |
| 213 | Prisma Health System Cancer Institute - Eastside | Greenville | South Carolina | United States | 29605 |
| 214 | Prisma Health System Cancer Institute - Faris | Greenville | South Carolina | United States | 29605 |
| 215 | Saint Francis Cancer Center | Greenville | South Carolina | United States | 29607 |
| 216 | Self Regional Healthcare | Greenwood | South Carolina | United States | 29646 |
| 217 | Prisma Health System Cancer Institute - Greer | Greer | South Carolina | United States | 29650 |
| 218 | Prisma Health System Cancer Institute - Butternut | Reidville | South Carolina | United States | 29605 |
| 219 | Prisma Health System Cancer Institute - Seneca | Seneca | South Carolina | United States | 29672 |
| 220 | Spartanburg Medical Center | Spartanburg | South Carolina | United States | 29303 |
| 221 | Prisma Health System Cancer Institute - Spartanburg | Spartanburg | South Carolina | United States | 29307 |
| 222 | Avera Cancer Institute-Aberdeen | Aberdeen | South Dakota | United States | 57401 |
| 223 | Monument Health Rapid City Hospital | Rapid City | South Dakota | United States | 57701 |
| 224 | Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | United States | 57104 |
| 225 | Avera Cancer Institute | Sioux Falls | South Dakota | United States | 57105 |
| 226 | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | United States | 57117 |
| 227 | Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee | United States | 38120 |
| 228 | Meharry Medical College | Nashville | Tennessee | United States | 37208 |
| 229 | Dell Seton Medical Center at The University of Texas | Austin | Texas | United States | 78701 |
| 230 | UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | United States | 75390 |
| 231 | UT Southwestern Clinical Center at Richardson/Plano | Richardson | Texas | United States | 75080 |
| 232 | University of Texas Health Science Center at San Antonio | San Antonio | Texas | United States | 78229 |
| 233 | Augusta Health Center for Cancer and Blood Disorders | Fishersville | Virginia | United States | 22939 |
| 234 | MultiCare Auburn Medical Center | Auburn | Washington | United States | 98001 |
| 235 | Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington | United States | 98310 |
| 236 | Harrison Medical Center | Bremerton | Washington | United States | 98310 |
| 237 | MultiCare Gig Harbor Medical Park | Gig Harbor | Washington | United States | 98335 |
| 238 | Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo | Washington | United States | 98370 |
| 239 | MultiCare Good Samaritan Hospital | Puyallup | Washington | United States | 98372 |
| 240 | Fred Hutchinson Cancer Research Center | Seattle | Washington | United States | 98109 |
| 241 | Seattle Cancer Care Alliance | Seattle | Washington | United States | 98109 |
| 242 | University of Washington Medical Center | Seattle | Washington | United States | 98115 |
| 243 | MultiCare Tacoma General Hospital | Tacoma | Washington | United States | 98405 |
| 244 | West Virginia University Charleston Division | Charleston | West Virginia | United States | 25304 |
| 245 | Ascension Southeast Wisconsin Hospital-Elmbrook Campus | Brookfield | Wisconsin | United States | 53045 |
| 246 | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin | United States | 53105 |
| 247 | Marshfield Medical Center - EC Cancer Center | Eau Claire | Wisconsin | United States | 54701 |
| 248 | Aurora Health Center-Fond du Lac | Fontana | Wisconsin | United States | 54937 |
| 249 | Ascension Saint Francis-Reiman Cancer Center | Franklin | Wisconsin | United States | 53132 |
| 250 | Aurora Health Care Germantown Health Center | Germantown | Wisconsin | United States | 53022 |
| 251 | Aurora Cancer Care-Grafton | Grafton | Wisconsin | United States | 53024 |
| 252 | Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin | United States | 53715 |
| 253 | Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin | United States | 54301 |
| 254 | Aurora BayCare Medical Center | Green Bay | Wisconsin | United States | 54311 |
| 255 | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | United States | 53412 |
| 256 | Gundersen Lutheran Medical Center | La Crosse | Wisconsin | United States | 54601 |
| 257 | Mayo Clinic Health System-Franciscan Healthcare | La Crosse | Wisconsin | United States | 54601 |
| 258 | William S Middleton VA Medical Center | Madison | Wisconsin | United States | 53705 |
| 259 | University of Wisconsin Hospital and Clinics | Madison | Wisconsin | United States | 53792 |
| 260 | Holy Family Memorial Hospital | Manitowoc | Wisconsin | United States | 54220 |
| 261 | Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin | United States | 54143 |
| 262 | Vince Lombardi Cancer Clinic-Marinette | Marinette | Wisconsin | United States | 54143 |
| 263 | Marshfield Medical Center - Marshfield | Marshfield | Wisconsin | United States | 54449 |
| 264 | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | United States | 53215 |
| 265 | Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin | United States | 53226 |
| 266 | Aurora Sinai Medical Center | Milwaukee | Wisconsin | United States | 53233 |
| 267 | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin | United States | 54548 |
| 268 | Ascension Mercy Hospital | Oshkosh | Wisconsin | United States | 54904 |
| 269 | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | United States | 54904 |
| 270 | Ascension All Saints Hospital | Racine | Wisconsin | United States | 53405 |
| 271 | Aurora Cancer Care-Racine | Racine | Wisconsin | United States | 53406 |
| 272 | Marshfield Medical Center - Rice Lake | Rice Lake | Wisconsin | United States | 54868 |
| 273 | Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin | United States | 53081 |
| 274 | Marshfield Clinic Stevens Point Center | Stevens Point | Wisconsin | United States | 54482 |
| 275 | Aurora Medical Center in Summit | Summit | Wisconsin | United States | 53066 |
| 276 | Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | United States | 54241 |
| 277 | Ascension Medical Group Southeast Wisconsin-Mayfair Road | Wauwatosa | Wisconsin | United States | 53226 |
| 278 | Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin | United States | 53226 |
| 279 | Aurora West Allis Medical Center | West Allis | Wisconsin | United States | 53227 |
| 280 | Marshfield Clinic-Weston Center | Weston | Wisconsin | United States | 54476 |
| 281 | Shaare Zedek Medical Center | Jerusalem | Israel | 9103102 |
Sponsors and Collaborators
- National Heart, Lung, and Blood Institute (NHLBI)
- National Cancer Institute (NCI)
Investigators
- Study Chair: Mikkael Sekeres, MD, MS, University of Miami
- Study Chair: Amy DeZern, MD, MHS, Johns Hopkins University
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
None provided.Responsible Party:
National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:
NCT02775383
Other Study ID Numbers:
- NHLBI-MDS
First Posted:
May 17, 2016
Last Update Posted:
Apr 12, 2022
Last Verified:
Apr 1, 2022
Keywords provided by National Heart, Lung, and Blood Institute (NHLBI)
Additional relevant MeSH terms: