Nationwide Trends in Incidence, Healthcare Utilization, and Mortality in Hospitalized Acute Myocardial Infarction Patients in Taiwan

Sponsor
Novartis Pharmaceuticals (Industry)
Overall Status
Completed
CT.gov ID
NCT05974397
Collaborator
(none)
124,018
1
9.7
12795.9

Study Details

Study Description

Brief Summary

This was a retrospective study using the Taiwan's National Health Insurance Research Database (NHIRD). The study employed two study designs for different purposes as follows:

  • A cross-sectional analysis was conducted to explore the annual incidence trends.

  • A longitudinal cohort study was conducted to assess baseline characteristics, treatment patterns, long-term healthcare utilization, and cause-specific mortality among incident AMI patients.

In each part, the study was conducted for AMI, and separately for ST-segment elevation and non-ST- segment elevation myocardial infarction (STEMI and NSTEMI)

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    124018 participants
    Observational Model:
    Cohort
    Time Perspective:
    Retrospective
    Official Title:
    Nationwide Trends in Incidence, Healthcare Utilization, and Mortality in Hospitalized Acute Myocardial Infarction Patients in Taiwan
    Actual Study Start Date :
    Sep 30, 2021
    Actual Primary Completion Date :
    Jul 22, 2022
    Actual Study Completion Date :
    Jul 22, 2022

    Arms and Interventions

    Arm Intervention/Treatment
    AMI

    Patients with AMI

    STEMI

    Patients with STEMI

    NSTEMI

    Patients with NSTEMI

    Outcome Measures

    Primary Outcome Measures

    1. Mean age of patients [12 months]

    2. Number of male patients [12 months]

    3. Year of patient entry into cohort [12 months]

    4. Number of patients with AMI in Taiwan [12 months]

    5. Number of patients with STEMI in Taiwan [12 months]

    6. Number of patients with NSTEMI in Taiwan [12 months]

    7. Number of AMI patients with comorbidities [Up to 3 years]

    8. Number of patients with treatment for AMI [Up to 3 years]

    9. Number of STEMI patients with comorbidities [Up to 3 years]

    10. Number of patients with treatment for STEMI [Up to 3 years]

    11. Number of NSTEMI patients with comorbidities [Up to 3 years]

    12. Number of patients with treatment for NSTEMI [Up to 3 years]

    13. Number of mortalities among AMI patients [Up to 3 years]

    14. Number of mortalities among STEMI patients [Up to 3 years]

    15. Number of mortalities among NSTEMI patients [Up to 3 years]

    16. Number of AMI patients with outpatient visits [Up to 3 years]

    17. Number of AMI patients with emergency room visits [Up to 3 years]

    18. Number of AMI patients with hospitalizations [Up to 3 years]

    19. Length of hospital stay for AMI patients [Up to 3 years]

    20. Direct medical costs for AMI patients [Up to 3 years]

    21. Number of STEMI patients with outpatient visits [Up to 3 years]

    22. Number of STEMI patients with emergency room visits [Up to 3 years]

    23. Number of STEMI patients with hospitalizations [Up to 3 years]

    24. Length of hospital stay for STEMI patients [Up to 3 years]

    25. Direct medical costs for STEMI patients [Up to 3 years]

    26. Number of NSTEMI patients with outpatient visits [Up to 3 years]

    27. Number of NSTEMI patients with emergency room visits [Up to 3 years]

    28. Number of NSTEMI patients with hospitalizations [Up to 3 years]

    29. Length of hospital stay for NSTEMI patients [Up to 3 years]

    30. Direct medical costs for NSTEMI patients [Up to 3 years]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    20 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    Cross-sectional analysis:
    • Patients aged 20 years and older.

    • Patients who had been admitted for AMI, defined as primary or first secondary diagnosis of AMI between 2014 and 2020.

    • The diagnosis of AMI/ STEMI/ NSTEMI was identified by the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes and 10th revision (ICD-10-CM) codes.

    • Incident cases of AMI hospitalization were defined as no history of AMI-related hospitalization or outpatient visit within 1 year before admission.

    Longitudinal analysis:

    Patients aged 20 years and older.

    • Patients who had been admitted for AMI, defined as primary or first secondary diagnosis of AMI between 2014 and 2017.

    • The diagnosis of AMI/ STEMI/ NSTEMI was identified by ICD-9-CM codes and ICD-10-CM codes. (The ICD-9-CM code and ICD-10-CM codes were the same as above)

    • Incident cases of AMI hospitalization were defined as no history of AMI-related hospitalization or outpatient visit within 1 year before admission.

    • The cohort entry date was defined as the admission date of incident AMI hospitalization, and the index date was defined as the discharge date of incident hospitalization.

    Exclusion Criteria:

    None specified

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Novartis Taipei Taiwan

    Sponsors and Collaborators

    • Novartis Pharmaceuticals

    Investigators

    • Study Director: Novartis Pharmaceuticals, Novartis Pharmaceuticals

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Novartis Pharmaceuticals
    ClinicalTrials.gov Identifier:
    NCT05974397
    Other Study ID Numbers:
    • CLCZ696BTW05
    First Posted:
    Aug 3, 2023
    Last Update Posted:
    Aug 3, 2023
    Last Verified:
    Jul 1, 2023
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Aug 3, 2023