Natural Frozen Embryo Transfer (FET) vs Substituted Frozen Embryo Transfer (FET)
Study Details
Study Description
Brief Summary
In frozen embryo transfer substituted cycles, patients are treated with progesterone and estrogen in an attempt to mimic the natural cycle and a transfer is planned whenever the endometrium is ready. In contrast, in frozen embryo transfer natural cycle patients are not taking any hormones, only triggered with hCG (human chorionic gonadotropin) when a dominant follicle is ready or they wait for the disappearance of the dominant follicle to plan the transfer date. Some doctors and centres shift towards using the substituted protocol in an attempt to make scheduling easier with less frequent ultrasounds.
This study will aim to compare clinical and biochemical pregnancy rates in patients who underwent frozen embryo transfers in natural cycles vs substituted cycles at the centre.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Frozen embryo transfer substituted cycle In a substituted cycle, estrogen and progesterone are given and a transfer is planned when the endometrium is ready |
Other: Frozen embryo transfer
A frozen embryo transfer involves thawing a fertilized embryo and transferring it in the uterus in order to obtain a pregnancy
|
| Frozen embryo transfer natural cycle In a natural cycle no hormones are given and a transfer is planned when there is a dominant follicle apparent at the ultrasound |
Other: Frozen embryo transfer
A frozen embryo transfer involves thawing a fertilized embryo and transferring it in the uterus in order to obtain a pregnancy
|
Outcome Measures
Primary Outcome Measures
- Evaluate the clinical pregnancy rate of embryo transfer in natural vs substituted cycles [6 to 8 weeks after Frozen Embryo Transfer]
clinical pregnancy is the presence of fetal heartbeat at the viability ultrasound
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age < 40 years old
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Women having undergone either a frozen embryo transfer in natural cycle or substituted cycle
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IVF and FET cycles done at Clinique OVO
Exclusion Criteria:
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egg or embryo recipient
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History of recurrent miscarriages, defined as ≥ 3 consecutive losses
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Patients that needed Viagra, Plasma-Rich Platelet (PRP) or other modalities to improve their endometrial thickness
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Uterine abnormalities
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Abnormal hormonal profiles
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FET Stimulated cycles
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History of recurrent implantation failure defined as failed ≥ 2 euploid embryos transfer or ≥ 3 blastocysts
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Clinique Ovo | Montréal | Quebec | Canada | H4P 2S4 |
Sponsors and Collaborators
- Clinique Ovo
Investigators
- Principal Investigator: Camille Sylvestre, MD, clinique ovo R&D department
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 3356