Natural History of Carotid Atherosclerosis
Study Details
Study Description
Brief Summary
A prospective study of 700 patients with coronary artery disease will undergo non invasive evaluation of their carotid arteries by ultrasound and microwave radiometry. The patients will be followed up for 3 years and their outcome regarding the cardiovascular events (death, cardiac events, cerebrovascular events) will be recorded
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
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Detailed Description
Carotid artery Thermal heterogeneity recorded by MR will be corelated to cardiovascular events (death, cardiac events, cerebrovascular events) as well as to all demographic (age, sex, hypertension, dyslipidemia, smoking status, etc) factors
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| carotid thermal heterogeneity Patients that have carotid thermal heterogeneity detected by MR |
|
| no carotid thermal heterogeneity Patients that DONT have carotid thermal heterogeneity detected by MR |
|
| carotid artery disease Patients with detected carotid artery disease by ultrasound |
|
| no carotid artery disease Patients with no carotid artery disease detected by ultrasound |
Outcome Measures
Primary Outcome Measures
- To detect if carotid ultrasound and carotid microwave radiometry measurements can predict the incidence of cerebrovascular and cardiovascular events in patients with coronary artery disease [3 years]
Microwave radiometry is a non invasive and safe technique that measures temperature of the internal tissues by detecting the normal radiation of the tissues in microwave frequencies. The primary outcome of the study is to see if the temperatures measured in the carotid arteries of patients with coronary artery disease can predict their outcome regarding cerebrovascular and cardiovascular events
Secondary Outcome Measures
- Relation of other demographic factors with carotid ultrasound and microwave radiometry measurements and outcome [3 years]
Eligibility Criteria
Criteria
Inclusion Criteria:
- Consecutive patients with coronary artery disease admitted in our hospital
Exclusion Criteria:
-
Patients with history of previous cerebrovascular event,
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History of vasculitis, intermittent inflammatory, infectious, or neoplastic conditions likely to be associated with an acute-phase response.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | First Department of Cardiology, University of Athens, Medical School. Hippocratio Hospital | Athens | Attiki | Greece | 11528 |
Sponsors and Collaborators
- National and Kapodistrian University of Athens
Investigators
- Principal Investigator: Konstantinos Toutouzas, First department of Cardiology, University of Athens Greece
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
- Toutouzas K, Benetos G, Drakopoulou M, Bounas P, Tsekoura D, Stathogiannis K, Koutagiar I, Aggeli C, Karanasos A, Panagiotakos D, Siores E, Stefanadis C. Insights from a thermography-based method suggesting higher carotid inflammation in patients with diabetes mellitus and coronary artery disease. Diabetes Metab. 2014 Dec;40(6):431-8. doi: 10.1016/j.diabet.2014.05.005. Epub 2014 Jun 26.
- Toutouzas K, Benetos G, Drakopoulou M, Deligianni C, Spengos K, Stefanadis C, Siores E, Tousoulis D. Incremental predictive value of carotid inflammation in acute ischemic stroke. Stroke. 2015 Jan;46(1):272-4. doi: 10.1161/STROKEAHA.114.007526. Epub 2014 Nov 4.
- Toutouzas K, Benetos G, Drakopoulou M, Michelongona A, Nikolaou C, Masoura C, Stathogiannis K, Aggeli C, Tsiamis E, Siores E, Stefanadis C. Morphological and functional assessment of carotid plaques have similar predictive accuracy for coronary artery disease. Stroke. 2013 Sep;44(9):2607-9. doi: 10.1161/STROKEAHA.113.002462. Epub 2013 Jul 25.
- Toutouzas K, Grassos H, Synetos A, Drakopoulou M, Tsiamis E, Moldovan C, Agrogiannis G, Patsouris E, Siores E, Stefanadis C. A new non-invasive method for detection of local inflammation in atherosclerotic plaques: experimental application of microwave radiometry. Atherosclerosis. 2011 Mar;215(1):82-9. doi: 10.1016/j.atherosclerosis.2010.12.019. Epub 2010 Dec 23.
- MRcar