Natural History of Optic Neuritis

Sponsor

National Institute of Neurological Disorders and Stroke (NINDS) (NIH)

Overall Status

Completed

CT.gov ID

NCT01851434

Collaborator

National Eye Institute (NEI) (NIH)

Enrollment

Locations

55.2

Actual Duration (Months)

2.7

Patients Per Site

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Background:

Optic neuritis often is a symptom of multiple sclerosis (MS). Many people who experience optic neuritis are later diagnosed with MS. MS disease activity seen on magnetic resonance imaging (MRI) scans is often greater than that seen in tests given during regular doctor's visits. Even though MRI is a helpful tool for studying optic neuritis and MS, more information is needed on how MS symptoms show up on MRI scans. Researchers want to use MRI scans to track changes in the optic nerve after an optic neuritis episode. This approach will help them study the relationship between optic neuritis and MS.

Objectives:

To collect more information about the relationship between optic neuritis and multiple sclerosis.

Eligibility:

Individuals between 18 and 50 years of age who have new optic neuritis.
Individuals between 18 and 50 years of age who have new symptoms of MS other than optic neuritis.
Healthy volunteers between 18 and 50 years of age.

Design:

Participants will be screened with a physical exam and medical history. They may provide blood or urine samples.
Participants with optic neuritis or other MS symptoms will have a baseline study visit. They will have a physical exam and full eye exam. To look for signs of MS, they will have evoked potential tests to see how the body responds to stimulation. They will also have an MRI scan to study any changes in the brain and optic nerves.
After the first visit, participants will have steroid treatment for 5 days for the optic neuritis.
Additional study visits will be given 1, 3, 6, 9, and 12 months after the baseline visit. The tests from the first visit, including the MRI scans, will be repeated at these visits.
Healthy volunteers will have a baseline study visit. They will have a physical exam and full eye exam. They will have evoked potential tests to see how the body responds to stimulation. They will also have an MRI scan to study any changes in the brain and optic nerves.
Healthy volunteers will have additional study visits 2 and 11 months after the baseline visit. The tests from the first visit, including the MRI scans, will be repeated at these visits.

Condition or Disease	Intervention/Treatment	Phase
Multiple Sclerosis

Detailed Description

Objective

The goals of this pilot study are:

To assess the degree to which subacute changes in clinical, electrophysiological, and imaging measures can robustly predict retinal neuronal loss 12 months after acute optic neuritis.
To construct a composite score that integrates these subacute changes, can itself robustly predict retinal neuronal loss 12 months after acute optic neuritis, can be validated in future trials, and is likely to be modulated by drugs that promote tissue repair and neuroprotection in multiple sclerosis (MS).
To evaluate the usefulness of specialized magnetic resonance imaging (MRI) measures of the optic nerve in future clinical trials of drugs designed to promote tissue repair and neuroprotection. The primary hypothesis of the study is that peripapillary retinal nerve fiber layer (RNFL) thickness, which is generally agreed to reflect the integrity of optic nerve axons following optic neuritis, and which can be measured using spectral-domain optical coherence tomography (OCT) in the affected eye 12 months following optic neuritis, can be robustly predicted by changes in RNFL thickness between 1 and 3 months following symptom onset.

Study Population

The following cohorts will be recruited at each of the three study sites:

Up to 30 participants with acute optic neuritis.
Up to 15 healthy volunteers who are group-wise age- and sex-matched to the participants with unilateral optic neuritis.

Design

This is a one-year, prospective, multi-cohort, multi-site, pilot natural history study. Data obtained at NIH will be compared and aggregated with data obtained at other study sites, specifically the University of Utah-Moran Eye Center (in Salt Lake City) and Hebrew University-Hadassah Medical Center (in Jerusalem, Israel). Data will be gathered at baseline (optional) and at 1, 3, 6, 9, and 12 months in the patient cohort, and at 1, 3, and 12 months in the healthy volunteers.

Outcome Measures

The primary outcome measure is the RNFL thickness in the affected eye 12 months after optic neuritis.

Secondary outcome measures, all measured at 12 months, include:

Measures of optic nerve structure: mean cross-sectional optic-nerve area; mean, parallel, and perpendicular diffusivity; and MTR all within the optic nerve lesion as visualized at baseline.
Measures of brain structure: ventricular volume; T2 lesion volume along the visual pathway both sides considered together.
Measures of retinal structure: ganglion cell layer + inner plexiform layer thickness in the affected eye.
Measures of visual function: low-contrast letter acuity; high-contrast letter acuity; Pelli-Robson contrast sensitivity; object-from-motion detection; visual fields; and critical flicker-fusion frequency all in the affected eye.
Measures of visual physiology: VEP amplitude; VEP latency all in the effected eye.

Study Design

Study Type:

Observational

Actual Enrollment :

8 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Natural History of Optic Neuritis

Actual Study Start Date :

Mar 20, 2013

Actual Primary Completion Date :

Sep 5, 2014

Actual Study Completion Date :

Oct 26, 2017

Arms and Interventions

Arm	Intervention/Treatment
healthy volunteers age- and sex-matched to the participants with unilateral optic neuritis and a brain MRI suggestive of MS
Patients with unilateral optic neuritis Recruitment will proceed until 10 participants with a brain MRI suggestive of MS (obtained at any time point during the study) have completed the study.

Outcome Measures

Primary Outcome Measures

The primary outcome measure is the RNFL thickness in the affected eye 12 months after optic neuritis [12 months after optic neuritis]
RNFL thickness in the affected eye 12 months after optic neuritis.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 50 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

INCLUSION CRITERIA:

COHORT 1: Unilateral optic neuritis.

Typical demyelinating optic neuritis based on the best clinical judgment of the investigators.
Symptom onset within 46 weeks of enrollment OR patients with history of optic neuritis who were followed from symptom onset under a Neuroimmunology Branch natural history or screening protocol.
For women of childbearing potential, willing to use acceptable forms of contraception (i.e. hormonal contraception (birth control pills, injected hormones, vaginal ring), intrauterine device, barrier methods (condom or diaphragm) with spermicide or they have undergone surgical sterilization (hysterectomy, tubal ligation, or vasectomy in a partner) for the study duration.
Able to provide informed consent.
Willing and able to participate in all aspects of the trial.

COHORT 2: Healthy volunteers.

No medical history that would interfere with study result interpretation, in the best clinical judgment of the investigators.
Age greater than or equal to 18 years and less than or equal to 50 years.
Able to provide informed consent.
Willing and able to participate in all aspects of the trial.

EXCLUSION CRITERIA:

History of signs or symptoms suspicious for MS, in the best clinical judgment of the investigators.
Pateints-Disease-modifying therapy for MS prior to the onset of the current episode of optic neuritis (excludes oral or intravenous glucocorticoids: Healthy Volunteers - Previous or current use of disease-modifying therapy for MS (excluding oral or intravenous glucocorticoids.
Previous history of clinical optic neuritis or a systemic disease associated with optic neuritis (e.g. sarcoidosis, lymphoma).
Current or prior optic neuropathy (e.g. trauma, ischemia, glaucoma, optic nerve drusen).
Previous history of a retinal disease (e.g. diabetic retinopathy, retinal drusen) other than uveitis.
Previous history of an ophthalmic disease that in the best judgment of the investigator could affect ophthalmic imaging results.
Previous history of a systemic disease that may mimic MS (e.g. neurosyphilis, neurosarcoidosis, CNS ymphoma, Si(SqrRoot)(Delta)gren s syndrome).
Previous history of a systemic disease that in the best judgment of the investigator could confound study outcome.
Current use of a TNF-alpha inhibitor (e.g. etanercept).
Habitual use of illicit drugs that in the best judgment of the investigators could confound study outcome.
Pregnant or breast-feeding.
Unwilling to co-enroll on a Neuroimmunology Branch natural history or screening protocol currently 89-N-0045.
Contraindication to MRI scanning.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	National Institutes of Health Clinical Center, 9000 Rockville Pike	Bethesda	Maryland	United States	20892
2	University of Utah	Salt Lake City	Utah	United States	84112
3	Hadassah Hospital/Hebrew University Medical Center	Jerusalem		Israel