Natural History and Patient Journey in Dementia: a Nationwide Linked Electronic Health Records Study of 5.6 Million Individuals.

• Sponsor: University College, London (Other)
• Overall Status: Unknown status
• CT.gov ID: NCT04321486
• Collaborator: (none)
• Enrollment: 4,309,481
• Anticipated Duration (Months): 275

Study Details

Study Description

Brief Summary

The trajectory of dementia patients within the national health system and their recent temporal trends remains to be fully elucidated. To study the dementia incidence, mortality and case-fatality, we implemented a longitudinal cohort study with the linked electronic health records of 5.6 million population in the UK from 1998 to 2016 (CALIBER). A matched case-control study design was used to investigate the causes of hospitalization and death comparing individuals with and without incident dementia.

Condition or Disease	Intervention/Treatment	Phase
Dementia, Alzheimer, Electronic Health Records, Hospitalizations, Epidemiology, Comorbidity, United Kingdom, Incidence, Mortality, Cause of Death	Other: The study does not have an intervention, but observe the dementia incidence of the UK disease-free population.

Study Design

• Study Type: Observational
• Actual Enrollment: 4309481 participants
• Observational Model: Cohort
• Time Perspective: Prospective
• Official Title: Natural History and Patient Journey in Dementia: a Nationwide Linked Electronic Health Records Study of 5.6 Million Individuals.
• Actual Study Start Date: Jan 1, 1998
• Actual Primary Completion Date: May 31, 2016
• Anticipated Study Completion Date: Nov 30, 2020

Outcome Measures

Primary Outcome Measures

1. Incidence and mortality of dementia [Jan 1st 1998 - May 31st 2016]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 30 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• We identify individuals aged 30 years or older and registered in the current primary care practice for at least one year.

Exclusion Criteria:

• Individuals are excluded if they had a prior history of dementia before study entry.

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

• University College, London

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: University College, London
• ClinicalTrials.gov Identifier: NCT04321486
• Other Study ID Numbers: ISAC18_228
• First Posted: Mar 25, 2020
• Last Update Posted: Nov 13, 2020
• Last Verified: Mar 1, 2020

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Dementia; Alzheimer Disease

Study Results

No Results Posted as of Nov 13, 2020