VAC and Conventional Dressing in the Healing Process of Necrotizing Fasciitis
Study Details
Study Description
Brief Summary
Find out the best management of Necrotizing Fasciitis after surgical debridement
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Necrotizing fasciitis is a life-threatening condition that can occur as a result of trauma or foreign bodies in surgical wounds as well as idiopathically. Necrotizing fasciitis is characterized by a progressive infection in fascial planes with necrosis of the subcutaneous tissue. Necrotizing fasciitis affects the extremities more frequently than central areas. Risk factors for necrotizing fasciitis include diabetes mellitus, trauma wound infections, decubitus ulcers, alcoholism, carcinoma, peripheral vascular disease, smoking, and intravenous drug abuse. A varieties of micro-organisms, including gram-positive group A streptococcus, haemolytic streptococci, and staphylococcus aureus; gram-negative Enterobacteriaceae, Escherichia coli, Klebsiella spp., and Proteus spp.; anaerobes including Peptostreptococcus, Clostridium, and Pacteroides; and fungi such as Candida and acid-fast bacteria have all been implicated in the pathogenesis of Necrotizing fasciitis.
Necrotizing fasciitis is a surgical emergency for detoxification by debridement with good antibiotic coverage. It has mortality rate reaching 20-30% , this mortality rate is high and requires prompt diagnosis, antibiotic treatment and extensive necrosectomy up to intensive care units admission in some cases, the aim of our prospective analysis is to assess with a hypothesis-generating and exploratory purpose the possible role of VAC versus ordinary dressings in the wound therapy of Necrotizing Fasciitis in terms of expected time for wound closure and survival rate.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Vacuum Assisted Closure device Vacuum Assisted Closure device for healing enhancement |
Device: VAC
Vacuum Assisted Closure device
|
| Experimental: Conventional dressing Unprocessed Honey, malysia glycerine and betadine ointment |
Device: VAC
Vacuum Assisted Closure device
|
Outcome Measures
Primary Outcome Measures
- Hospital staying length [Baseline]
the difference in hospital stay length between patients with necrotizing fasciitis who received conventional management versus those treated with vacuum-assisted closure. A systematic review showed a significant difference between the two methods
Secondary Outcome Measures
- Required other stages of debridement [Baseline]
Comparison in the other stages of debridement required in both methods
- Expected closure of the wound by secondary intention [Baseline]
The difference in expected time required for closure of the wound by secondary intention between patients with necrotizing fasciitis who received conventional management versus those treated with vacuum-assisted closure.
Eligibility Criteria
Criteria
Inclusion Criteria:
- Immunocompromised patients such as; diabetic, HIV and leukaemia.
And other chronic debilitating diseases.
Exclusion Criteria:
- Necrotizing Fasciitis of Head and neck and upper limbs.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Assiut University | Assiut | Egypt |
Sponsors and Collaborators
- Assiut University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Necrotizing fasciitis