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Nephropathy in Patients With Sickle Cell Disease

Sponsor
Assiut University (Other)
Overall Status
Unknown status
CT.gov ID
NCT03680547
Collaborator
(none)
25
Enrollment
8
Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

There are some diseases that give rise to diverse renal manifestations as does sickle cell disease

Condition or Disease Intervention/Treatment Phase
  • Other: patient with sickle cell disease

Detailed Description

Such involvement adversely affects virtually all major physiological processes in the kidney, and leads to complications that are common and chronic on the one hand (such as impaired urinary concentrating ability), and those that are rare and uniformly fatal on the other (such as renal medullary carcinoma) This steady adverse renal sequelae shortens the average lifespan of patients with SCD.

Proteinuria and a reduced glomerular filtration rate are risk factors associated with increased mortality among those patients with approximately 16-18% of overall mortality in this patient group is due to kidney disease.

Once end stage renal disease is reached, the mortality of patients who are on haemodialysis and have SCD is increased severalfold relative to the mortality of patients who are on haemodialysis but do not have SCD.

Thus,although the average lifespan of patients with SCD has increased during recent decades owing to improved management of complications outside the kidney,kidney disease contributes substantially to the still increased mortality in SCD.

Study Design

Study Type:
Observational
Anticipated Enrollment :
25 participants
Observational Model:
Other
Time Perspective:
Cross-Sectional
Official Title:
Pattern of Sickle Cell Nephropathy in Patients With Sickle Cell Disease
Anticipated Study Start Date :
May 1, 2020
Anticipated Primary Completion Date :
May 30, 2020
Anticipated Study Completion Date :
Jan 1, 2021

Outcome Measures

Primary Outcome Measures

  1. sickle cell nephropathy in patient with sickle cell disease [one year]

    detection of renal impairment in patients with sickle cell disease by estamating gloerular and tubular dysfunction clinicaly and laboratory

Eligibility Criteria

Criteria

Ages Eligible for Study:
5 Months to 18 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  • All patients with sickle cell anemia attending the unit will be included in the study.
Exclusion Criteria:
  • patient with any underlaying systemic diseases other than sickle cell anaemia

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

  • Assiut University

Investigators

  • Principal Investigator: omnia talat hasan, assiut

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
omnia talat hasan, assiut, Assiut University
ClinicalTrials.gov Identifier:
NCT03680547
Other Study ID Numbers:
  • npscd
First Posted:
Sep 21, 2018
Last Update Posted:
Nov 29, 2019
Last Verified:
Nov 1, 2019
Individual Participant Data (IPD) Sharing Statement:
Undecided
Plan to Share IPD:
Undecided
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:
Kidney Diseases
Anemia, Sickle Cell

Study Results

No Results Posted as of Nov 29, 2019