LOSS: Neural Mechanisms of Decision Making in Hoarding Disorder

• Sponsor: Stanford University (Other)
• Overall Status: Active, not recruiting
• CT.gov ID: NCT03487224
• Collaborator: (none)
• Enrollment: 25
• Location: 1
• Anticipated Duration (Months): 70.7
• Patients Per Site Per Month: 0.4

Study Details

Study Description

Brief Summary

The purpose of this study is to understand the neural mechanisms of decision making in hoarding disorder.

Condition or Disease	Intervention/Treatment	Phase
Hoarding Disorder	Device: MRI with fMRI frequency

Detailed Description

Hoarding disorder is a common and disabling disorder that represents a significant public health problem. This study aims to build on current research on decision making by examining these processes in hoarding disorder.

Study Design

• Study Type: Observational
• Anticipated Enrollment: 25 participants
• Observational Model: Cohort
• Time Perspective: Cross-Sectional
• Official Title: Neural Mechanisms of Decision Making in Hoarding Disorder
• Actual Study Start Date: Jul 8, 2018
• Anticipated Primary Completion Date: May 30, 2024
• Anticipated Study Completion Date: May 30, 2024

Arms and Interventions

Arm	Intervention/Treatment
Hoarding Disorder Adults diagnosed with Hoarding Disorder	Device: MRI with fMRI frequency; Functional magnetic resonance imaging or fMRI measures brain activity by detecting changes in blood flow. Participants will do cognitive tasks during fMRI.
Healthy Controls Adults without mental illness	Device: MRI with fMRI frequency; Functional magnetic resonance imaging or fMRI measures brain activity by detecting changes in blood flow. Participants will do cognitive tasks during fMRI.

Outcome Measures

Primary Outcome Measures

1. BOLD signal [up to 90 minutes]

   BOLD signal derived from fMRI

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 70 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Identify inclusion criteria.

Inclusion criteria for participants diagnosed with HD:

1. ages 18-70

2. primary diagnosis of hoarding disorder

3. sufficient severity of hoarding symptoms

4. stable on psychotropic medications for 1 month prior to study enrollment

5. capacity to provide informed consent

6. ability to tolerate clinical study procedures

Inclusion criteria for healthy control participants:

1. ages 18-70

2. capacity to provide informed consent

Identify exclusion criteria.

Exclusion criteria for participants with HD:

1. psychiatric or medical conditions that make participation unsafe

2. pregnant or nursing females

3. concurrent use of any medications that might increase the risk of participation (e.g. drug interactions)

4. presence of metallic device or dental braces

Exclusion criteria for healthy control participants:

1. any current or lifetime psychiatric diagnosis

2. current or past use of psychotropic medication

3. pregnant or nursing females

4. major medical or neurological problem

5. presence of metallic device or dental braces

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Stanford University	Stanford	California	United States	94305

Sponsors and Collaborators

• Stanford University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Additional Information:

• Stanford Medicine Faculty Page
• Rodriguez Lab Website

Publications

None provided.

• Responsible Party: Carolyn Rodriguez, Assistant Professor, Stanford University
• ClinicalTrials.gov Identifier: NCT03487224
• Other Study ID Numbers: 42327
• First Posted: Apr 3, 2018
• Last Update Posted: Aug 19, 2022
• Last Verified: Aug 1, 2022

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Keywords provided by Carolyn Rodriguez, Assistant Professor, Stanford University: Hoarding Disorder
• Additional relevant MeSH terms: Disease; Hoarding Disorder

Study Results

No Results Posted as of Aug 19, 2022