Effects of Intense Exercise on Neural Responses to Food.

• Sponsor: University of Birmingham (Other)
• Overall Status: Completed
• CT.gov ID: NCT01926431
• Collaborator: (none)
• Enrollment: 16
• Location: 1
• Arms: 2
• Duration (Months): 19.9
• Patients Per Site Per Month: 0.8

Study Details

Study Description

Brief Summary

The primary aim of this study was to determine the effects of an acute bout of high intensity exercise on the brains response to viewing pictures of food using functional magnetic resonance imaging (fMRI).

Condition or Disease	Intervention/Treatment	Phase
Neural Responses; Appetite Hormones; Subjective Appetite Sensations	Other: Exercise; Other: Rest	N/A

Detailed Description

It is clear that intense exercise impacts on peripheral appetite regulation, however very little is known about the impact of high-intensity exercise on central appetite regulation. This study aimed to investigate the effects of high-intensity exercise on both central and peripheral responses to images of food. Functional magnetic resonance techniques were used to assess the brains response to images of high and low calorie foods, following a short bout of high-intensity exercise. Appetite hormone concentrations were also measured. It was hypothesized that, due to the known effects of high-intensity exercise on appetite regulatory hormones and subjective appetite ratings, the activation of reward-related brain regions to visual food cues would be modulated following intense physical activity.

Study Design

• Study Type: Interventional
• Actual Enrollment: 16 participants
• Allocation: Randomized
• Intervention Model: Crossover Assignment
• Masking: None (Open Label)
• Primary Purpose: Basic Science
• Official Title: The Effects of High Intensity Exercise on Neural Responses to Images of Food
• Study Start Date: Sep 1, 2009
• Actual Primary Completion Date: May 1, 2011
• Actual Study Completion Date: May 1, 2011

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Exercise 60 minutes of high intensity treadmill running	Other: Exercise
Experimental: Rest 60 minutes of seated rest (control trial)	Other: Rest

Outcome Measures

Primary Outcome Measures

1. Neural responses following exercise and rest [Ten minutes post-exercise/rest]

   Volunteers completed an fMRI assessment following 60 minutes of intense exercise and 60 minutes of rest on two separate occasions.

Secondary Outcome Measures

1. Appetite hormones [Blood samples taken at baseline, following exercise/rest, prior to the fMRI assessment and immediately following the fMRI assessment]

   Blood samples were taken using a cannula system for both trials. Concentrations of appetite regulating hormones were measured from plasma.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 30 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Healthy, non-smokers, free from cardiovascular disease and metabolic disease, no medication, participated in moderate/vigorous physical activity (>2 hours per week)

Exclusion Criteria:

• Smokers, history of cardiovascular/metabolic disease, low physical activity levels, inability to participate in fMRI scanning sessions including contraindications to MRI

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Birmingham University Imaging Centre	Birmingham	Midlands	United Kingdom	B15 2TT

Sponsors and Collaborators

• University of Birmingham

Investigators

• Principal Investigator: Andrew Blannin, PhD, University of Birmingham

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Daniel Crabtree, Principal Investigator, University of Birmingham
• ClinicalTrials.gov Identifier: NCT01926431
• Other Study ID Numbers: fMRI Study; ERN_09-586
• First Posted: Aug 21, 2013
• Last Update Posted: Aug 21, 2013
• Last Verified: Aug 1, 2013

Study Results

No Results Posted as of Aug 21, 2013