Long-term Consequences of Neuroimaging and Perceived Cognitive Dysfunction in oPRES
Study Details
Study Description
Brief Summary
The purpose of this study is to explore the long-term consequences of neuroimaging and perceived cognitive dysfunction in obstetrics posterior reversible encephalopathy syndrome.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
This is a prospective study. The investigators divided the PE or E patients into two groups, namely PRES group and non-PRES group, according to diagnostic criteria . The general information（demographic data，blood pressure.etc.）and blood sample will be collected. Additionally,all patients receive neuroimaging examination（DTI,ASL,3D-TMI.etc.）and neuro-cognitive test（MMSE,MOCA,CFQ, etc.） to assess the cerebral white matter lesions and cognitive changes.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| PRES group PE or E with PRES |
Biological: neuroimaging examination,neuro-cognitive test,blood pressure,blood sample
neuroimaging will be perform,neuro-cognitive will be tested,blood pressure will be monitored,blood samples will be tested
|
| non-PRES group PE or E without PRES |
Biological: neuroimaging examination,neuro-cognitive test,blood pressure,blood sample
neuroimaging will be perform,neuro-cognitive will be tested,blood pressure will be monitored,blood samples will be tested
|
Outcome Measures
Primary Outcome Measures
- neuroimaging examination [within 10 years after deliver]
the degree of white matter lesions(0,normal; 1, limited cortical or subcortical white matter oedema; 2, white matter oedema > cortical oedema, white matter oedema extending into deep white matter; 3, white matter oedema > cortex oedema, oedema extending to the ventricular surface; 4, the involved regions substantially extend to the ventricular surface and are almost completely confluent; 5, involved regions are fully confluent and continuous, ventricular deformity due to the oedema).The value of fractional anisotropy(FA) in PRES group may higher than non- PRES group, and mean diffusivity (MD) in PRES group may lower than non- PRES group.
- neuro-cognitive test of Mini-mental State Examination [within 10 years after deliver]
the scores of Mini-mental State Examination,normal (27-30);mild (21-26); moderate (10-20); severe (0-9).
- neuro-cognitive test of Montreal Cognitive Assessment [within 10 years after deliver]
the scores of Montreal Cognitive Assessment,normal (≥26); abnormal (<26).
- blood pressure and hypertension [within 10 years after deliver]
Hypertension: blood pressure ≥140/90 mmHg
- level of lactate dehydrogenase(LDH) [within 10 years after deliver]
inflammatory: LDH>380U/L
- level of LDL in blood [within 10 years after deliver]
hyperlipidemia：LDL>3.12mmol/L
Eligibility Criteria
Criteria
Inclusion Criteria:
-
patients were diagnosed of PE or E
-
patients received cranial image examination
-
patients consent to participate
Exclusion Criteria:
-
patients combined other neurological diseases
-
patients combined mental illness
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University | Guangzhou | China | 510150 |
Sponsors and Collaborators
- Dunjin Chen
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 82001568