Neuromuscular Ultrasound in Correlation to Neurophysiological Findings

Sponsor
Assiut University (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT04092140
Collaborator
(none)
100
37

Study Details

Study Description

Brief Summary

  1. Study the neuromuscular ultrasound findings in different types of neuropathies

  2. correlation between ultrasound and neurophysiological findings in peripheral nerve diseases

  3. correlation between clinical pain scale and severity of neuropathy

Condition or Disease Intervention/Treatment Phase
  • Device: ultrasound

Detailed Description

Ultrasonography is a diagnostic tool that is increasingly used in the work-up of peripheral nerve disease.

As many peripheral nerves run a superficial course, especially in the arms. This is a big advantage over Magnetic Resonance Imaging that is relatively expensive, time consuming and not readily available everywhere.

Nerve cross-sectional area (CSA) can be determined at multiple sites along the nerve.

CSA can be measured at entrapment sites but also at nonentrapment sites. vascularization, echogenicity, fascicular pattern and endoneurial thickness can be investigated as well. All those modalities can give critical insight in the origin and development of various peripheral neuropathies1,2,3

Major peripheral nerves in the extremities, such as the median,ulnar thick enough to reflect the sound beam, resulting in hyperechoic on the US scan 4.

The correlation between nerve conduction study parameters and CSA in ultrasound Ultrasound of the peripheral nervous system is an additional useful diagnostic tool in neuromuscular disorders..5,6,7,8,9 In the longitudinal plane, nerves present as long, slim structures with a mixture of parallel hypoechoic and hyperechoic lines.

Nerves must be distinguished from other nearby structures to ensure correct identification Muscles are hypoechoic and interspersed with small hyperechoic foci which easily distinguishes muscles from nerves. Tendons, which are sometimes adjacent to nerves, move proportionately with joint movement.

US has higher specificity than sensitivity in differentiating myopathic and neuropathic changes The most sensitive diagnostic marker for symptomatic carpal tunnel syndrome patients is an enlarged crosssectional area of the median nerve 10,11,12

Study Design

Study Type:
Observational
Anticipated Enrollment :
100 participants
Observational Model:
Case-Control
Time Perspective:
Cross-Sectional
Official Title:
Neuromuscular Ultrasound Changes in Neuropathies in Correlation to Neurophysiological Findings
Anticipated Study Start Date :
Oct 1, 2019
Anticipated Primary Completion Date :
Oct 1, 2022
Anticipated Study Completion Date :
Nov 1, 2022

Arms and Interventions

Arm Intervention/Treatment
diabetic complaining of neuropathy or not

using of ultrasound in examination and nerve conduction study

Device: ultrasound
easy new non invasive tool
Other Names:
  • ultrasonography
  • carpal tunnel syndrome

    using of ultrasound in examination and nerve conduction study

    Device: ultrasound
    easy new non invasive tool
    Other Names:
  • ultrasonography
  • Outcome Measures

    Primary Outcome Measures

    1. Nerve ultrasound [3 years]

      on median and ulnar nerves

    2. muscle Ultrasound [3 years]

      on thenar and hypothenar muscles

    3. nerve conduction studies [3 years]

      for median and ulnar nerves (sensory and motor)

    4. Electromyogram [3 years]

      for thenar and hypothenar

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 70 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • above 18 years old

    • males or females

    • diabetic complaining of neuropathy or not

    • carpal tunnel syndrome

    • Guillain-BarrĂ© syndrome

    Exclusion Criteria:
    • Patient refuse to participate

    • The anatomy is altered due to sever trauma,tumor,or surgery

    • Severe spasticity preventing examination

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • Assiut University

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Shahera Sayed Ahmed Abd El Maged, Resident doctor at neuropsychiatry department, Assiut University
    ClinicalTrials.gov Identifier:
    NCT04092140
    Other Study ID Numbers:
    • ultrasound in neuropathies
    First Posted:
    Sep 17, 2019
    Last Update Posted:
    Sep 19, 2019
    Last Verified:
    Sep 1, 2019
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Sep 19, 2019