EXCIDRAH: Neuronal Excitability of HCN1 Channel Mutations in Dravet Syndrome
Sponsor
Fondation Ophtalmologique Adolphe de Rothschild (Other)
Overall Status
Recruiting
CT.gov ID
NCT02896608
Collaborator
(none)
110
1
84
1.3
Study Details
Study Description
Brief Summary
This study addresses the changes in the axonal excitability parameters. It will compare these changes in patients with early infantile epileptic encephalopathy with HCN1 channel mutation and in control patients, with and without epilepsy.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Study Type:
Observational
Anticipated Enrollment
:
110 participants
Observational Model:
Other
Time Perspective:
Cross-Sectional
Official Title:
Neuronal Excitability of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN1) Channel Mutations in Dravet Syndrome
Actual Study Start Date
:
Oct 1, 2015
Anticipated Primary Completion Date
:
Oct 1, 2022
Anticipated Study Completion Date
:
Oct 1, 2022
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Dravet syndrome - HCN1 channel mutation early infantile epileptic encephalopathy with HCN1 channel mutation |
Device: measure of neuronal excitability
|
| control with epilepsy
|
Device: measure of neuronal excitability
|
| control without epilepsy
|
Device: measure of neuronal excitability
|
Outcome Measures
Primary Outcome Measures
- hyperpolarizing electrotonus [baseline]
- hyperpolarizing threshold current [baseline]
Eligibility Criteria
Criteria
Ages Eligible for Study:
15 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
-
early infantile epileptic encephalopathy with HCN1 channel mutation
-
control patients with no neurologic pathology (age, gender and body temperature matched)
-
epileptic patients (age, gender and body temperature matched)
Exclusion Criteria:
- pregnant or breast feeding patient
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Fondation Ophtalmologique Adolphe de Rothschild | Paris | France | 75019 |
Sponsors and Collaborators
- Fondation Ophtalmologique Adolphe de Rothschild
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Fondation Ophtalmologique Adolphe de Rothschild
ClinicalTrials.gov Identifier:
NCT02896608
Other Study ID Numbers:
- AGN_2015_11
First Posted:
Sep 12, 2016
Last Update Posted:
Dec 27, 2021
Last Verified:
Dec 1, 2021