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Simultaneous PET/MR Imaging of Human Brain Plasticity

Sponsor
Rupert Lanzenberger (Other)
Overall Status
Unknown status
CT.gov ID
NCT03485066
Collaborator
(none)
40
Enrollment
1
Location
2
Arms
42.1
Anticipated Duration (Months)
1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Background: Neuronal plasticity is the brain's ability to continuously adapt to experiences and learning of new skills. Although this affects multiple characteristics of the brain such as structure, function and metabolism, direct interactions between these aspects are largely missing.

Aim: Using recent advancements in neuroimaging we aim to identify novel relationships how neuronal plasticity is related across these characteristics.

Design: 40 healthy subjects will undergo two simultaneous PET/MR measurements at baseline and after 4 weeks. During the measurements a cognitively challenging task will be performed and the training group (20 subjects) will practice during the 4-week period.

Implications: We combine simultaneous PET/MR and novel task-specific PET imaging to study brain metabolism, structure and function in a single measurement session. This provides optimal sensitivity for assessment of multimodal neuroplasticity associations. Knowledge how cognitive training affects multiple characteristics of the brain will also increase our understanding of disorders like depression, dementia and brain injuries, since these are diagnosed with cognitive evaluations. Considering the vast usage of the applied imaging procedures in diagnosis and therapy monitoring, the thorough investigation of multimodal associations offers benefit for the interpretability of neuroimaging in clinical routine.

Condition or Disease Intervention/Treatment Phase
  • Behavioral: Tetris
 N/A

Detailed Description

Methodological details: Each subject will undergo two PET/MR examinations. Imaging will include PET as well as acquisition of structural and functional MRI. Task-specific glucose metabolism will be quantified with the radioligand [18F]FDG. Gray matter volume and white matter microstructure will be assessed with T1-weighted and diffusion weighted MRI, respectively. Functional imaging will focus on functional connectivity during rest and task as well as cerebral blood flow as acquired with ASL.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
40 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Single (Outcomes Assessor)
Primary Purpose:
Basic Science
Official Title:
Multimodal Associations of Human Brain Plasticity Investigated With Simultaneous PET/MR Imaging
Actual Study Start Date :
May 1, 2017
Anticipated Primary Completion Date :
Nov 1, 2020
Anticipated Study Completion Date :
Nov 1, 2020

Arms and Interventions

Arm Intervention/Treatment
Experimental: Training

20 healthy participants, 4 week training of a challenging cognitive task (Tetris) between PET/MR measurements

Behavioral: Tetris
The video game Tetris is a cognitively challenging task, which requires mental rotation, problem solving and fast visuo-spatial and motor coordination.
No Intervention: Control

20 healthy participants, no training between PET/MR measurements

Outcome Measures

Primary Outcome Measures

  1. Training induced changes in imaging parameters [4 weeks]

    Imaging parameters are glucose metabolism ([18F]FDG PET), cerebral blood flow (arterial spin labeling MRI), functional connectivity (resting-state and task fMRI), gray matter volume (T1-weighted MRI) and white matter structure (diffusion weighted MRI)

Secondary Outcome Measures

  1. Cognitive performance [4 weeks]

    Training induced changes in performance of the video game (score per minute)

Eligibility Criteria

Criteria

Ages Eligible for Study:
21 Years to 30 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:

  • Age range 21-30 years

  • Right-handedness

  • Willingness and competence to sign the informed consent form

Exclusion Criteria:

  • History of or current physical, neurological or psychiatric disorder

  • History of or current substance abuse or medication including antipsychotic, antidepressant and antianxiety agents

  • Pregnancy or current breastfeeding

  • Contraindications for MRI-scanning (e.g., metal implants, steel grafts, etc), including dental implants causing signal artifacts

  • For subjects participating in earlier studies using ionizing radiation, the total radiation exposure of 30mSv over the last 10 years must not be exceeded, as specified in the Austrian legislation on radiation protection

  • Regular players of the video game Tetris (3 years before scanning).

  • Failure to comply with the study protocol or to follow the instructions of the investigating team

Contacts and Locations

Locations

Site City State Country Postal Code
1 Department of Psychiatry and Psychotherapy, Medical University of Vienna Vienna Austria

Sponsors and Collaborators

  • Rupert Lanzenberger

Investigators

  • Study Director: Rupert Lanzenberger, Assoc Prof, Department of Psychiatry and Psychotherapy, Medical University of Vienna

Study Documents (Full-Text)

None provided.

More Information

Additional Information:

Publications

None provided.
Responsible Party:
Rupert Lanzenberger, Assoc.Prof. PD MD, Head of Neuroimaging Labs, Medical University of Vienna
ClinicalTrials.gov Identifier:
NCT03485066
Other Study ID Numbers:
  • PSY-NIL-0005
First Posted:
Apr 2, 2018
Last Update Posted:
Sep 23, 2019
Last Verified:
Sep 1, 2019
Individual Participant Data (IPD) Sharing Statement:
Undecided
Plan to Share IPD:
Undecided
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No

Study Results

No Results Posted as of Sep 23, 2019