Neuropsychological Evaluation for Early Diagnosis of PSP
Study Details
Study Description
Brief Summary
The aim of this study is to better understand the nature of the cognitive decline in Progressive Supranuclear Palsy, the time of its development and the relation with the other cardinal features of the disease.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Progressive Supranuclear Palsy (PSP) is a neurodegenerative disease characterized by vertical supranuclear gaze palsy, early balance dysfunction and falls. Tau-protein aggregation, mainly in the brainstem, is the disease hallmark. Because of the similarities with Parkinson's disease (PD), the diagnosis is made approximately 4 years after the symptoms onset. Cognitive deficits are a leading feature of PSP and they actually represent one of the four functional core domains in the revised diagnostic criteria. The aim of this study is to better understand the nature of this cognitive decline, the time of its development and the relation with the other cardinal features of the disease.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| PSP patients Patients suffering from Progressive Supranuclear Palsy (PSP) |
Behavioral: Cognitive evaluation
An extensive battery of neuropsychological and motor tests was assessed: MMSE, FAB, MoCA, WCST, Stroop Test, TMT-A and B, Verbal fluency Test, ROCF copy and delayed recall, RAVLT, 6MWT, TUG, BBS.
|
| PD Patients Patients suffering from Parkinson's disease (PD) |
Behavioral: Cognitive evaluation
An extensive battery of neuropsychological and motor tests was assessed: MMSE, FAB, MoCA, WCST, Stroop Test, TMT-A and B, Verbal fluency Test, ROCF copy and delayed recall, RAVLT, 6MWT, TUG, BBS.
|
Outcome Measures
Primary Outcome Measures
- MMSE [1 year]
Mini-Mental State Examination
- FAB [1 year]
Frontal Assessment Battery
- MoCA [1 year]
Montreal Cognitive Assessment
- WCST [1 year]
Wisconsin Card Sorting Test
- ST [1 year]
Stroop Test
- TMT-A and B [1 year]
Trail Making Test Parts A & B
- VFT [1 year]
Verbal fluency Test
- ROCF copy and delayed recall [1 year]
Rey-Osterrieth complex figure test copy and delayed recall
- RAVLT [1 year]
Rey Auditory Verbal Learning Test
Secondary Outcome Measures
- 6MWT [1 year]
6 Minute Walk Test
- TUG [1 year]
Timed Up and Go Test
- BBS [1 year]
Berg Balance Scale
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patients fulfilling the criteria for idiopathic PD
-
Patients fulfilling the criteria for PSP
Exclusion Criteria:
- Any other neurodegenerative disorders or medical conditions different from PD / PSP
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Ospedale Generale Di Zona Moriggia-Pelascini
Investigators
- Principal Investigator: Giuseppe Frazzitta, MD, Department of Parkinson's disease, Movement Disorders and Brain Injury Rehabilitation, "Moriggia-Pelascini" Hospital - Via Pelascini, 3, 22015, Gravedona ed Uniti, Como, Italy
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NPsy-PSP