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Neurotoxic Health Hazards of Long-Term Low-Level Exposure to Organophosphate (OP) Compounds in in Hula Valley

Sponsor
Shaare Zedek Medical Center (Other)
Overall Status
Unknown status
CT.gov ID
NCT00671866
Collaborator
(none)
1
Location

Study Details

Study Description

Brief Summary

During 1987-1991, WHO supported studies of exposures and short term neurobehavioral effects in a cohort (n=200) with occupational and community exposures to pesticide drift containing organophosphates from orchards and cotton fields in the Hula Valley. We aim (1) to re-examine neurobehavioral outcomes in members of the original cohort and (2) to examine cognitive effects in children with residential exposures. In adults, we will carry out assays of alkyl phosphates, PON1 (paraoxonase-1), NTE (Neuropathy Target Esterase), neurobehavioral tests of cognitive and performance skills, nerve conduction measurements and mood status. We will carry out Psycho-Didactic tests in children. The findings will advance knowledge on delayed term health effects of lengthy everyday exposure to OP pesticides and guide regulatory policy.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Observational Model:
    Cohort
    Time Perspective:
    Cross-Sectional

    Arms and Interventions

    Arm Intervention/Treatment
    1

    Agricultural Workers
    2

    Non - Agricultural Workers
    3

    Kibbitz Residents working else where

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      N/A and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:
      • Participants of the former study twenty years ago

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Neurology and Toxicology Unit and Service, Shaare Zedek Med Ctr Jerusalem Israel 91031

      Sponsors and Collaborators

      • Shaare Zedek Medical Center

      Investigators

      None specified.

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00671866
      Other Study ID Numbers:
      • y.finkelstein.ctil.
      First Posted:
      May 5, 2008
      Last Update Posted:
      May 5, 2008
      Last Verified:
      Apr 1, 2008
      Keywords provided by , ,
      OP
      Pesticides
      Long-Term Low Level Exposure
      Occupational Health
      Neurobehavioral Effects
      Additional relevant MeSH terms:
      Peripheral Nervous System Diseases

      Study Results

      No Results Posted as of May 5, 2008