New-onset Heart Blocks After Noncardiac Surgery: a Retrospective Study of More Than 280,000 Patients

Sponsor

Chinese PLA General Hospital (Other)

Overall Status

Completed

CT.gov ID

NCT06119009

Collaborator

(none)

281,497

Enrollment

139

Actual Duration (Months)

Study Details

Study Description

Brief Summary

This study aimed to investigate new-onset heart blocks after noncardiac surgery, identify risk factors, and develop a prediction model.

Condition or Disease	Intervention/Treatment	Phase
Heart Block Risk Factor	Other: non interventions

Detailed Description

Objective: This study aimed to investigate new-onset heart blocks after noncardiac surgery, identify risk factors, and develop a prediction model.

Methods: A retrospective cohort study included 281,497 patients aged 18 or older who underwent noncardiac surgery at a single center between Jan 2008 and Aug 2019. The main outcome was postoperative new-onset heart blocks within one year, including atrioventricular and bundle blocks. Prognostic impact was assessed using Kaplan-Meier survival curves and time-dependent Cox regression analysis. Perioperative data was used for machine learning models (logistic regression, support vector machine, random forest, decision tree). Model performance was measured using the area under the receiver operating characteristic curve (AUC).

Study Design

Study Type:

Observational

Actual Enrollment :

281497 participants

Observational Model:

Cohort

Time Perspective:

Retrospective

Official Title:

New-onset Heart Blocks After Noncardiac Surgery: a Retrospective Study of More Than 280,000 Patients

Actual Study Start Date :

Jan 1, 2008

Actual Primary Completion Date :

Aug 1, 2019

Actual Study Completion Date :

Aug 1, 2019

Arms and Interventions

Arm	Intervention/Treatment
Non- Heart blocks The number of patients who did not suffered the heart blocks in the postoperative 1-year period	Other: non interventions
Heart blocks The number of patients who suffered the heart blocks in the postoperative 1-year period	Other: non interventions

Arm

Intervention/Treatment

Non- Heart blocks

The number of patients who did not suffered the heart blocks in the postoperative 1-year period

Other: non interventions

Heart blocks

The number of patients who suffered the heart blocks in the postoperative 1-year period

Other: non interventions

Outcome Measures

Primary Outcome Measures

New-onset heart blocks [within one year after surgery]
The number of new-onset heart blocks within one year after surgery, including first-, second-, and third-degree AV blocks and left- and right-branch bundle blocks

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

patients above 18 yrs undergoing noncardiac surgery at the First Medical Center of the Chinese People's Liberation Army General Hospital (PLAGH) from January 1, 2008 to August 1, 2019.