NF2 Natural History Consortium

• Sponsor: House Ear Institute (Other)
• Overall Status: Unknown status
• CT.gov ID: NCT00004483
• Collaborator: (none)
• Enrollment: 100
• Location: 1

Study Details

Study Description

Brief Summary

OBJECTIVES:

1. Define the growth rates and clinical course of NF2-related tumors in patients with neurofibromatosis type 2. Associate growth rate with physical function.

Condition or Disease	Intervention/Treatment	Phase
Schwannoma, Vestibular; Neurofibromatosis 2; Meningioma

Detailed Description

PROTOCOL OUTLINE: Data on the clinical course and growth rate of NF2-related tumors in patients with neurofibromatosis 2. Patients are evaluated each year on a cranial and a spinal MRI, eye tests, hearing tests, quality of life, neurological tests, and physical functioning.

Study Design

• Study Type: Observational
• Observational Model: Natural History
• Time Perspective: Other
• Study Start Date: Jan 1, 2002

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

• Ages Eligible for Study: 5 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics--

• Diagnosed with neurofibromatosis 2 on or after 01/01/93

• Must meet one of the following conditions:

Bilateral vestibular schwannoma OR Family history of neurofibromatosis 2 (first degree family relative) AND Unilateral vestibular schwannoma at under 30 years OR Any 2 of the following: Meningioma Glioma Schwannoma Juvenile posterior subcapsular lenticular opacity/juvenile cortical cataract

• No plans to treat vestibular schwannoma in next 12 months

--Prior/Concurrent Therapy--

• Not specified

--Patient Characteristics--

• Age: 5 and over

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	House Ear Institute	Los Angeles	California	United States	90057-9927

Sponsors and Collaborators

• House Ear Institute

Investigators

• Study Chair: William H. Slattery, III, House Ear Institute

Study Documents (Full-Text)

None provided.

More Information

Publications

• Fisher, Laurel M., Slattery, WIlliam H. III, Yoon, Gloria. MRI Test-Retest Study of NF2 Patients. Abstract Submitted to: Combined Otolaryngological Spring Meetings (COSM).
• Masuda A, Fisher LM, Oppenheimer ML, Iqbal Z, Slattery WH; Natural History Consortium. Hearing changes after diagnosis in neurofibromatosis type 2. Otol Neurotol. 2004 Mar;25(2):150-4.
• Masuda, Ann. Slattery, William H. III, Fisher, Laurel M., Oppenheimer, Mark. Audiological Characteristics of Initial Presentation of NF2 Patients: Preliminary Results. Abstract submitted to: Combined Otolaryngological Spring Meetings (COSM).
• Slattery WH 3rd, Fisher LM, Iqbal Z, Oppenhiemer M. Vestibular schwannoma growth rates in neurofibromatosis type 2 natural history consortium subjects. Otol Neurotol. 2004 Sep;25(5):811-7.
• Slattery WH, Lev MH, Fisher LM, Connell SS, Iqbal Z, Go JL; NF2 Natural History Consortium. MRI evaluation of neurofibromatosis 2 patients: a standardized approach for accuracy in interpretation. Otol Neurotol. 2005 Jul;26(4):733-40.
• Slattery, William H. III, Fisher, Laurel M. Considerations in the Development of the NF2 Natural History Consortium. Submitted to Otolaryngology-Head and Neck Surgery.
• Zacharia, T., Lev, M., Iqbal, Z.T., Fisher ,L.M. , Gupta, MS, Slattery, WH. (2003) Intramedullary Spinal Tumors In NF II: Incidence And Imaging Characteristics American Radiology Society, 2003.

• ClinicalTrials.gov Identifier: NCT00004483
• Other Study ID Numbers: 199/14226; HEI-NF2; HEI-DAMD17-01-1-0710
• First Posted: Oct 19, 1999
• Last Update Posted: Sep 29, 2005
• Last Verified: Sep 1, 2005

• Additional relevant MeSH terms: Meningioma; Neurofibromatoses; Neurilemmoma; Neurofibromatosis 2; Neuroma, Acoustic

Study Results

No Results Posted as of Sep 29, 2005