Nomograms to Precisely Predict Conditional Risk of Survival for Patients With Laryngeal Cancer
Study Details
Study Description
Brief Summary
Advanced laryngeal squamous cell carcinoma (SCC) remains a highly morbid and fatal disease despite aggressive interventions. Mortality is high in this cohort: laryngeal cancer affects over 13 000 patients in the United States, with over 3500 deaths annually.The results of the Veterans Affairs Cooperative Studies Program Laryngeal Cancer Trial and subsequent studies demonstrated similar overall survival (OS) rates for organ preservation protocols involving radiotherapy (RT) or chemoradiotherapy (CRT) when compared to surgery, with the benefit of preserving the larynx in a large majority of patients. As such, the use of RT or CRT has become the predominant initial intervention for patients with laryngeal SCC.However, the prognosis of recurrent and persistent laryngeal SCC is particularly dire.In this study,the investigators sought to identify preoperative predictors of survival for patients with recurrent or persistent laryngeal SCC in order to set patient expectations and address modifiable risk factors. Identification of predictors of survival may also identify patients who could benefit from novel therapeutic agents in a neo/adjuvant fashion. Herein,we examine a cohort of patients with recurrent or persistent laryngeal SCC after definitive RT/CRT who has undergone total laryngectomy in order to identify potential preoperative predictors of clinical outcomes.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Demographic, clinical, and survival data were abstracted. Death was verified via medical records and the social security death index. Primary outcome measures were OS (time from salvage laryngectomy to death from any cause), disease-specific survival (DSS; time from salvage laryngectomy to death from recurrent/persistent laryngeal SCC), and DFS (time from salvage laryngectomy to laryngeal SCC recurrence)
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Survival Group status from radical operation to follow-up |
Procedure: Radical Operation
The surgery treatment selection was based on the American Joint Committee on Cancer stage both of the primary and of the recurrence, as well as on patterns of local spread that were not included in the T classification and on the general condition and preferences of each patient.
|
| Non-Survival Group status from radical operation to follow-up |
Procedure: Radical Operation
The surgery treatment selection was based on the American Joint Committee on Cancer stage both of the primary and of the recurrence, as well as on patterns of local spread that were not included in the T classification and on the general condition and preferences of each patient.
|
Outcome Measures
Primary Outcome Measures
- Overall survival [Follow up 5 year]
time from laryngectomy to death from any cause
Eligibility Criteria
Criteria
Inclusion Criteria:
- laryngeal carcinoma patients with radical surgery
Exclusion Criteria:
- multiple primarry malignant neo-plasms
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Genglong Liu | Guangzhou | State... | China | 510080 |
Sponsors and Collaborators
- First Affiliated Hospital, Sun Yat-Sen University
Investigators
- Study Chair: Xiaojun Tan, Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Laryngeal cacer