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CMR-TECH: Non-contrast Enhanced Cardiac Magnetic Resonance Normal Values and Imaging Protocols

Sponsor
Medical University of Graz (Other)
Overall Status
Recruiting
CT.gov ID
NCT01728597
Collaborator
Amt der Steiermärkischen Landesregierung, Abteilung 3 (Other)
200
Enrollment
1
Location
192
Duration (Months)
1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

One of the main problems in cardiac magnetic resonance (MR) investigations is the strong dependence of the achieved image quality on optimal settings of sequence parameters and anatomical and physiological situations and it is well known that the diagnostic impact of cardiac MR investigations crucially depends on the adaption of imaging protocols to patients' state and ability to cooperate.

The aim of the present study is the evaluation and optimization of various 1.5 Tesla and 3 Tesla cardiac MR investigation protocols without application of contrast agent as well as the acquisition of normal values for new cardiac MR images techniques:

  • normal myocardial morphology: T1-, T2- and T2*-weighted imaging and acquisition of normal values of magnetic relaxation times (sequence- and protocol dependent),

  • normal cardiac function: systolic and diastolic function (sequence- and protocol dependent),

  • coronary artery imaging: feasibility to evaluate length, diameter and blood flow (sequence- and protocol dependent),

  • normal blood flow topologies in the heart and the surrounding great vessels: 2D- and 3D blood flow imaging and evaluation techniques (sequence- and protocol dependent).

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    200 participants
    Observational Model:
    Other
    Time Perspective:
    Other
    Official Title:
    Optimization of Non-contrast Enhanced 1.5 Tesla and 3 Tesla Cardiac Magnetic Resonance Imaging Techniques and Acquisition of Normal Values
    Study Start Date :
    Dec 1, 2011
    Anticipated Primary Completion Date :
    Dec 1, 2022
    Anticipated Study Completion Date :
    Dec 1, 2027

    Arms and Interventions

    Arm Intervention/Treatment
    healthy volunteers

    MR compliant volunteers with no history of cardiovascular diseases

    Outcome Measures

    Primary Outcome Measures

    1. cardiac volumes [up to 1 week]

      volumes of cardiac chambers in the cardiac cycle [ml], sequence- and protocol dependent

    2. cardiac performance [up to 1 week]

      ejection fraction of cardiac chambers [%], sequence- and protocol dependent

    3. cardiac muscle mass [up to 1 week]

      systolic and end-diastolic mass of cardiac chambers [g], sequence- and protocol dependent

    4. coronary artery anatomy [up to 1 week]

      length and diameter [mm], sequence-, and protocol dependent

    5. blood flow velocity [up to 1 week]

      maximum, minimum and average velocity [cm/s], sequence-, and protocol dependent

    6. blood flow vorticity [up to 1 week]

      number of vortices of blood flow in the heart and surrounding great vessels, sequence and protocol dependent

    7. blood flow timing [up to 1 week]

      time points of characteristic blood flow patterns in the heart and surrounding great vessels in the cardiac cycle [ms], sequence-, and protocol dependent

    8. magnetic relaxation times [up to 1 week]

      systolic and diastolic T1, T2, T2* [ms], sequence- and protocol dependent

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 80 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • No history of cardiac or pulmonary diseases

    • ability to give informed consent

    Exclusion Criteria:

    • General MR exclusion criteria eg. patients with metal devices or other magnetic material in or on the subjects body which will be hazardous for MR investigation (e.g. heart pace-maker, brain aneurysm clip, nerve stimulators, electrodes, penile implants, coloured contact lenses, patch to deliver medications through the skin, any metal implants as rods, joints, plates, pins, screws, nails or clips, embolization coil, or any metal fragments or shrapnel in the body),

    • pregnancy,

    • claustrophobia.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Medical Unitersity Graz, Department of Radiology, Division of General Radiology Graz Styria Austria 8036

    Sponsors and Collaborators

    • Medical University of Graz
    • Amt der Steiermärkischen Landesregierung, Abteilung 3

    Investigators

    • Principal Investigator: Ursula Reiter, PhD, Medical Unitersity Graz, Department of Radiology, Division of General Radiology

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    Responsible Party:
    Ursula Reiter, PhD, Medical University of Graz
    ClinicalTrials.gov Identifier:
    NCT01728597
    Other Study ID Numbers:
    • CMR-12-TECH-02
    First Posted:
    Nov 20, 2012
    Last Update Posted:
    May 3, 2022
    Last Verified:
    May 1, 2022
    Keywords provided by Ursula Reiter, PhD, Medical University of Graz
    no history of cardiovascular diseases

    Study Results

    No Results Posted as of May 3, 2022