Dosimetry Study of Betalutin for Treatment of Relapsed Non-Hodgkin Lymphoma (LYMRIT-37-02)

Sponsor

Nordic Nanovector (Industry)

Overall Status

Withdrawn

CT.gov ID

NCT02657447

Collaborator

(none)

Enrollment

Location

Arms

32.4

Anticipated Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study is a phase I, open label, randomized study to assess pharmacokinetics, biodistribution and radiation dosimetry of lutetium (177Lu) lilotomab satetraxetan (Betalutin®) radioimmunotherapy in patients with relapsed non-Hodgkin lymphoma. The study will also investigate the safety, toxicity and efficacy of Betalutin and pre-dosing.

Condition or Disease	Intervention/Treatment	Phase
Non-Hodgkin Lymphoma	Drug: Betalutin with lilotomab dose 1 Drug: Betalutin with lilotomab dose 2	Phase 1

Study Design

Study Type:

Interventional

Actual Enrollment :

0 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

A Phase 1, Open Label, Randomized Study to Assess Pharmacokinetics, Biodistribution and Radiation Dosimetry of Lutetium (177Lu) Lilotomab Satetraxetan (Betalutin®) Radioimmunotherapy in Patients With Relapsed Non-Hodgkin Lymphoma

Actual Study Start Date :

Dec 19, 2017

Anticipated Primary Completion Date :

Sep 1, 2019

Anticipated Study Completion Date :

Sep 1, 2020

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Arm 1: Betalutin with lilotomab dose 1 Betalutin 15 MBq/kg b.w. with lilotomab pre-dosing	Drug: Betalutin with lilotomab dose 1 15 MBq/kg b.w. Betalutin (lutetium (177Lu) lilotomab satetraxetan) single injection, with lilotomab pre-dosing, dose 1 Other Names: Betalutin Lymrit 37-02 lutetium (177Lu) lilotomab satetraxetan HH1 177Lu-DOTA-HH1
Experimental: Arm 2: Betalutin with lilotomab dose 2 Betalutin 15MBq/kg b.w. with lilotomab pre-dosing	Drug: Betalutin with lilotomab dose 2 15 MBq/kg b.w. Betalutin (lutetium (177Lu) lilotomab satetraxetan) single injection, with lilotomab pre-dosing, dose 2 Other Names: Betalutin Lymrit 37-02 lutetium (177Lu) lilotomab satetraxetan HH1 177Lu-DOTA-HH1

Arm

Intervention/Treatment

Experimental: Arm 1: Betalutin with lilotomab dose 1

Betalutin 15 MBq/kg b.w. with lilotomab pre-dosing

Drug: Betalutin with lilotomab dose 1

15 MBq/kg b.w. Betalutin (lutetium (177Lu) lilotomab satetraxetan) single injection, with lilotomab pre-dosing, dose 1

Other Names:

Betalutin

Lymrit 37-02

lutetium (177Lu) lilotomab satetraxetan

HH1

177Lu-DOTA-HH1

Experimental: Arm 2: Betalutin with lilotomab dose 2

Betalutin 15MBq/kg b.w. with lilotomab pre-dosing

Drug: Betalutin with lilotomab dose 2

15 MBq/kg b.w. Betalutin (lutetium (177Lu) lilotomab satetraxetan) single injection, with lilotomab pre-dosing, dose 2

Other Names:

Betalutin

Lymrit 37-02

lutetium (177Lu) lilotomab satetraxetan

HH1

177Lu-DOTA-HH1

Outcome Measures

Primary Outcome Measures

Dosimetry [3 weeks]
Estimation of individual tumour/organ uptake and retention of radioactivity.

Secondary Outcome Measures

The number of participants with adverse events as assessed by NCTCAE. [12 weeks]
Adverse events by treatment group.
Efficacy (Best overall response rate) [3 months - 1 year]
Best overall response rate by treatment group as measured by Cheson Criteria.
Lilotomab pharmacokinetics [3 weeks]
Estimation using decay correction measurements

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Histologically confirmed (by WHO classification) relapsed indolent non-Hodgkin B-cell lymphoma of following subtypes: Follicular lymphoma (follicular grade I-IIIA), Marginal zone lymphoma (exclusion of MZL if large lymphocytes > 50%), Small lymphocytic lymphoma, Lymphoplasmacytoid and classical mantle cell lymphoma (no blastoid MCL).
Requiring initiation of treatment for the NHL.
Relapsed after at least one line of therapy including rituximab combination chemotherapy regimen.
Exhausted and/or ineligible for all standard treatment options.
Not a candidate for an autologous or allogeneic stem cell transplantation. Patients in progression after successful stem cell collection before before high-dose therapy and autologous stem cell transplantation may be considered for enrolment.
Age ≥ 18 years..
A pre-study ECOG performance status of 0-2. In selected patients an ECOG score of 3 can be acceptable if it is clearly lymphoma-associated at the discretion of the investigator.
Life expectancy should be ≥ 3 months.
1. < 25% tumour cells in bone marrow biopsy prior to lilotomab/Betalutin treatment (biopsy taken from a site not previously irradiated).
All patients must have at least one bi-dimensionally measurable lesion (>1.5 cm in its largest dimension by CT scan). Patients without such a target lesion can be accepted on an individual basis if histological organ involvement can be evaluated for response e.g. involvement of the skin or the gastrointestinal tract.
Women of childbearing potential must:

have a negative serum pregnancy test at screening and before Betalutin injection
understand that the study medication is expected to have teratogenic risk
agree to use, and be able to comply with, highly effective method of birth control with a Pearl-Index ≤ 1%. Contraception is required without interruption, 4 weeks before starting study drug, throughout study drug therapy and for 12 months after end of study drug therapy, even if she has amenorrhoea.

Male subjects must agree to use condoms during intercourse throughout study drug therapy and the following 12 months.
Patients previously treated with native rituximab are eligible.
The patient is willing and able to comply with the protocol, and agrees to return to the hospital for follow-up visits and examination.
The patient has been fully informed about the study and has signed the informed consent form.
Negative HAMA test.
CD37 positive, re-biopsy or test on existing tumour material if not known

Exclusion Criteria:

Medical contraindications, including uncontrolled infection, severe cardiac, pulmonary, neurologic, psychiatric or metabolic disease, steroid requiring asthma/allergy, known HIV positive.
Laboratory values during screening :

Absolute Neutrophil Counts (ANC) ≤ 1.5 x 109 /l
Platelet count ≤ 150 x 109 /l
Total bilirubin ≥ 30 mmol/l
ALP and ALAT ≥ 4x normal level
GFR < 60 ml/min/1.73 m2 as measured by the CKD-EPI method.

Known or suspected CNS involvement of lymphoma
Previous total body irradiation, or irradiation of > 25% of the patient's bone marrow.
Chemotherapy, immunotherapy or another investigational drug received within the last 4 weeks prior to the patient entering screening.
Earlier treatment with radioimmunotherapy.
Exposure to another CD37 targeting drug.
Concurrent participation in another therapeutic treatment trial.
Previous hematopoietic stem cell transplantation (autologous and allogenic).
Pregnant or lactating women.
Transformed or potentially transformed NHL from indolent to aggressive
Receipt of live, attenuated vaccine within 30 days prior to enrolment
Test positive for hepatitis B (HBsAg and anti-HBc)
A known hypersensitivity to rituximab, HH1, Betalutin or murine proteins or any excipient used in rituximab, HH1 or Betalutin
Malignant disease, other than that being treated in this study. Exceptions include: malignancies that were treated curatively and have not recurred within 3 years prior to study entry; completely resected basal cell and squamous cell skin cancers; completely resected carcinoma in situ of any type.