Non-surgical Treatment of Knee Osteoarthritis - a Comparison of Effects in 2200 Patients

Sponsor

Northern Orthopaedic Division, Denmark (Other)

Overall Status

Completed

CT.gov ID

NCT02091830

Collaborator

(none)

2,262

Enrollment

Location

17.9

Duration (Months)

126.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to assess whether radiographic osteoarthritis severity (OA; Kellgren-Lawrence scale) is associated with self-reported improvement in pain after non-surgical treatments (physiotherapy, pain killers, injection, other treatments).

The hypothesis is that radiographic OA severity is inversely associated with self-reported improvement.

Condition or Disease	Intervention/Treatment	Phase
Knee Osteoarthritis	Drug: Paracetamol and nonsteroidal antiinflammatory drug (NSAID) Other: Physiotherapy Drug: Cortisone Injection Other: Others

Study Design

Study Type:

Observational

Actual Enrollment :

2262 participants

Observational Model:

Cohort

Time Perspective:

Retrospective

Official Title:

Non-surgical Treatment of Knee Osteoarthritis - a Comparison of Effects in 2200 Patients

Study Start Date :

Jan 1, 2013

Actual Primary Completion Date :

Jul 1, 2014

Actual Study Completion Date :

Jul 1, 2014

Arms and Interventions

Arm	Intervention/Treatment
Non-surgical treatment	Drug: Paracetamol and nonsteroidal antiinflammatory drug (NSAID) Other: Physiotherapy Drug: Cortisone Injection Other: Others

Arm

Intervention/Treatment

Non-surgical treatment

Drug: Paracetamol and nonsteroidal antiinflammatory drug (NSAID)

Other: Physiotherapy

Drug: Cortisone Injection

Other: Others

Outcome Measures

Primary Outcome Measures

Self-reported improvement [2-5 years after consulting orthopedic surgeon]
Assessed using the question: Has your pain improved? Response categories: pain free; better; unchanged; worse

Eligibility Criteria

Criteria

Ages Eligible for Study:

N/A and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Not eligible for at total knee arthroplasty

Exclusion Criteria:

Ipsilateral knee arthroplasty

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Department of Orthopedic Surgery	Aalborg		Denmark	9000

Sponsors and Collaborators

Northern Orthopaedic Division, Denmark

Investigators

Study Chair: Michael Rathleff, MSc, Department of Occupational Therapy and Physiotherapy, Aalborg University Hospital, Denmark.
Study Chair: Mikkel M Andersen, MSc, Department of Mathematical Sciences, Aalborg University
Principal Investigator: Ole Simonsen, MD, DMSc, Department of Orthopedic Surgery
Study Chair: Christina A Derosche, BSc, Department of Orthopedic Surgery
Study Chair: Signe B Pedersen, Department of Orthopedic Surgery
Study Chair: Søren T Skou, MSc, Orthopedic Surgery Research Unit + Department of Health Science and Technology, Aalborg University