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NOSOGRIPPE: Nosocomial Influenza Surveillance of 2022 - 2027 Seasonal Period

Sponsor
Hospices Civils de Lyon (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT05712759
Collaborator
(none)
350
Enrollment
49
Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

Hospital-Acquired Influenza (HAI) is closely linked to the intensity of influenza in the community. HAI is associated with significant morbidity, mortality and extra costs due to prolonged hospital stay. The incidence of laboratory confirmed HAI has been reported rarely.

The proportion of HAI among influenza cases was 11.38% (95% Confidence Interval:

5.19%-19.55%) in a meta-analysis of 14 studies. In France, a prospective surveillance study of adults with Influenza-Like Illness (ILI) over 11 years, reported that 35.6% of the influenza cases diagnosed at hospital were hospital-acquired.

HAI is transmitted via respiratory droplets and by hand contacts. The spread is facilitated by Health Care Professionals (HCPs), patients and visitors.

Prevention and control of HAI is of upmost importance to preserve patient safety and limit the related economic costs. While vaccination of HCPs has been shown to contribute to the reduction of HAI, less is known on the impact of patient vaccination on the risk of HAI during hospitalization.

The aim of this study is to describe the hospital-acquired influenza in a french university hospital.

Condition or Disease Intervention/Treatment Phase
  • Other: Influenza-like illness group

Study Design

Study Type:
Observational
Anticipated Enrollment :
350 participants
Observational Model:
Other
Time Perspective:
Prospective
Official Title:
Surveillance of Nosocomial Influenza at Edouard Herriot University Hospital, Lyon, France
Anticipated Study Start Date :
Apr 1, 2023
Anticipated Primary Completion Date :
May 1, 2027
Anticipated Study Completion Date :
May 1, 2027

Outcome Measures

Primary Outcome Measures

  1. To describe and document cases of nosocomial influenza occurring at Edouard Herriot Hospital. [At inclusion]

    The primary endpoint will be assessed by the proportion of patients with nosocomial influenza among all patients with influenza-like illness during an influenza season.

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:

  • Any volunteer adult patient (≥ 18 years of age) hospitalized for at least 24 hours on a study unit, who had a nasopharyngeal swab taken as part of care for the purpose of diagnosing influenza by PCR testing and who had an influenza-like illness meeting the following definition:

  • Fever greater than 37.8°C in the absence of antipyretics; And/or

  • Cough or pharyngeal pain.

Exclusion Criteria:
  • Any person who does not meet the above definition or who has expressed opposition.

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

  • Hospices Civils de Lyon

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Hospices Civils de Lyon
ClinicalTrials.gov Identifier:
NCT05712759
Other Study ID Numbers:
  • 69HCL22_1064
First Posted:
Feb 3, 2023
Last Update Posted:
Feb 6, 2023
Last Verified:
Feb 1, 2023
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Hospices Civils de Lyon
influenza
hospital
nosocomial
Additional relevant MeSH terms:
Influenza, Human
Virus Diseases

Study Results

No Results Posted as of Feb 6, 2023