Nutritional Status, Muscle Wasting and Fraility in Intensive Care Patients
Study Details
Study Description
Brief Summary
The risk of muscle wasting is high in the intensive care unit patients during the treatment process and this condition is associated with adverse clinical outcomes. The etiology of muscle wasting is multifactorial and medical nutrition therapy plays a key role in muscle wasting treatment and prevention. The aim of this study is assesing the malnutrition and fraility, anthropometric measurements, and muscle mass by ultrasound at the first admission to the intensive care unit and to determine the nutritional factors affecting clinical outcomes. In addition, it is planned to determine the risk factors affecting the change of anthropometric measurements and muscle wasting in the first week during the intensive care unit.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
A nutrition-focused physical examination is an integral component in the assessment of critically ill patients. Malnutrition, muscle wasting, and frailty are multidimensional clinical conditions in critically ill patients and are associated with adverse outcomes. Although malnutrition, muscle wasting and frailty are linked, the exact relation between them is unsure. As a result of evaluating these conditions together, it is planned to develop new treatment strategies and to improve the clinical results of patients by determining the relationship between medical nutrition therapy.
Study Design
Outcome Measures
Primary Outcome Measures
- Changes in muscle cross-sectional area [Baseline and 7 days]
Rectus femoris muscle cross-sectional area will be evaluated by ultrasound.
- Changes in anthropometric measurements [Baseline and 7 days]
Triceps skinfold thickness will be measured by caliper.
Secondary Outcome Measures
- Duration of mechanical ventilation [Time of admission to the ICU until the time of discharge from the intensive care unit, up to 1 year]
Duration of mechanical ventilation in survivors and non survivors
- Mortality rate [Time of admission to the ICU until the time of discharge from the intensive care unit, up to 1 year]
ICU mortality
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age ≥45 years and ≤80 years, male or female
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Expected ICU stay of seven days or longer
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Written informed consent or requirements of local/national ethical committee
Exclusion Criteria:
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Pregnancy or breastfeeding
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Neuromuscular conditions (e.g., multiple sclerosis, muscular dystrophy, spinal cord injury, Guillain-Barre syndrome)
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Terminal cancer
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Dialysis dependent chronic renal failure
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Intoxication
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Burn injury
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A cognitive impairment prior to the acute illness that is associated with admission to ICU that would impair capacity to follow verbal instructions
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Concurrent enrolment in a nutrition-related interventional study at the time of screening
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Karadeniz Technical University Faculty of Health Sciences | Trabzon | Eyalet/Yerleşke | Turkey | 61080 |
Sponsors and Collaborators
- Karadeniz Technical University
Investigators
- Principal Investigator: Ahmet Oguzhan Kucuk, MD, Karadeniz Technical University
- Principal Investigator: Hulya Ulusoy, Professor, Karadeniz Technical University
- Principal Investigator: Ayse Ozfer Ozcelik, Professor, Ankara University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 202057