Effects of Aerobic and Resistance Training on Abdominal Fat Loss

Sponsor

Southern Illinois University Edwardsville (Other)

Overall Status

Terminated

CT.gov ID

NCT03700827

Collaborator

Washington University School of Medicine (Other)

Enrollment

Location

Arms

Actual Duration (Months)

0.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Study the effects of different exercise modes on total and regional adiposity variation in subcutaneous and visceral adipose tissue (VAT and SAT). The investigators hypothesize that total abdominal will improve for all the exercise groups compared to the control group. When comparing intervention groups: 1) no differences on the degree of improvement in total abdominal fat depots (VAT and SAT) 2) different degree of change when comparing specific sections at VAT and SAT are expected.

Condition or Disease	Intervention/Treatment	Phase
Obesity, Abdominal	Other: Resistance Training Other: Aerobic Training	N/A

Study Design

Study Type:

Interventional

Actual Enrollment :

18 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

Effects of Aerobic and Resistance Training on Abdominal Fat Loss

Actual Study Start Date :

Oct 1, 2017

Actual Primary Completion Date :

Apr 1, 2020

Actual Study Completion Date :

May 1, 2020

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Resistance Training Group Resistance training will consist of 3 whole body circuits per week for 3 weeks lasting approximately 1 hour per session. All major muscle groups will be involved (leg press, bent-over-row, bench press, back squat, dumbbell jump squats, dead-lifts, and weighted abdominal crunches). Each participant will go through each circuit three times with 30 seconds between each exercise and 2 minutes between each set.	Other: Resistance Training High-intensity Resistance Training Group
Experimental: Aerobic Training Group Aerobic interval training will consist of 3 sessions/week for 3 weeks for approximately 45-50 minutes per session depending on exercise energy expenditure. There will be two periods of intervals. The first period will be 3 minutes of high-intensity activity and the second period will be reduced to moderate-intensity for 2 minutes. The speed/incline will change depending on the participants perception or Borg's rating of perceived exertion. Intensity will be measured using Lactate levels after each session.	Other: Aerobic Training Aerobic Interval Training Group
No Intervention: Control Group The control group must attend sessions but will not exercise.

Arm

Intervention/Treatment

Experimental: Resistance Training Group

Resistance training will consist of 3 whole body circuits per week for 3 weeks lasting approximately 1 hour per session. All major muscle groups will be involved (leg press, bent-over-row, bench press, back squat, dumbbell jump squats, dead-lifts, and weighted abdominal crunches). Each participant will go through each circuit three times with 30 seconds between each exercise and 2 minutes between each set.

Other: Resistance Training

High-intensity Resistance Training Group

Experimental: Aerobic Training Group

Aerobic interval training will consist of 3 sessions/week for 3 weeks for approximately 45-50 minutes per session depending on exercise energy expenditure. There will be two periods of intervals. The first period will be 3 minutes of high-intensity activity and the second period will be reduced to moderate-intensity for 2 minutes. The speed/incline will change depending on the participants perception or Borg's rating of perceived exertion. Intensity will be measured using Lactate levels after each session.

Other: Aerobic Training

Aerobic Interval Training Group

No Intervention: Control Group

The control group must attend sessions but will not exercise.

Outcome Measures

Primary Outcome Measures

Changes in Visceral Abdominal Tissue (VAT) [2 assessment periods: at baseline and week 4]
Changes in VAT will be measured using Magnetic Resonance Imaging

Secondary Outcome Measures

Changes in Subcutaneous Abdominal Tissue (SAT) [2 assessment periods: at baseline and week 4]
Changes in SAT will be measured using Magnetic Resonance Imaging
Changes in Muscular Strength [2 assessment periods: at baseline and week 4]
Changes in muscular strength will be assessed by one-repetition maximum test on leg press and bench press
Changes in Cardiorespiratory Function [2 assessment periods: at baseline and week 4]
Changes in cardiorespiratory will measured on a treadmill with a metabolic cart
Changes in fat mass (kg) [2 assessment periods: at baseline and week 4]
Changes in fat mass will be measured using dual-energy x-ray absorptiometry
Changes in relative body fat (%BF) [2 assessment periods: at baseline and week 4]
Changes in body composition (relative body fat, lean body mass and fat mass) will be measured using dual-energy x-ray absorptiometry
Changes in relative lean body mass (kg) [2 assessment periods: at baseline and week 4]
Changes in lean body mass will be measured using dual-energy x-ray absorptiometry
Changes in Lipid profile (TG, Total Cholesterol, HDL2 HDL3, LDL) [2 assessment periods: at baseline and week 4]
Samples will be processed to obtain serum and plasma, and stored at -80°c until analysis
Changes in concentration of Troponin [2 assessment periods: at baseline and week 4]
Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Changes in concentration of Fibrinogen [2 assessment periods: at baseline and week 4]
Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Changes in concentration of C-reactive protein (CRP) [2 assessment periods: at baseline and week 4]
Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Changes in concentration of IL-6 [2 assessment periods: at baseline and week 4]
Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Changes in concentration of IL-10 [2 assessment periods: at baseline and week 4]
Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Changes in concentration of TNF-alpha [2 assessment periods: at baseline and week 4]
Will be performed using a Luminex MAGPIX System with xPONENT 4.2

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 35 Years

Sexes Eligible for Study:

Female

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

30 - 39.9 kg/m2 BMI
White/Caucasian
Female
Sedentary

Exclusion Criteria:

Known cardiovascular, pulmonary, metabolic disease
Pregnant females
Any excluded criteria with MRI scans (i.e. certain metal implants, recent tattoos)
Diabetic
Hypertension
Cigarette smoking
MRI related contraindications (metal, no removable devices, etc.)

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Southern Illinois University of Edwardsville	Edwardsville	Illinois	United States	62026

Sponsors and Collaborators

Southern Illinois University Edwardsville
Washington University School of Medicine

Investigators

Principal Investigator: Maria Fernandez del Valle, PhD, Southern Illinois University of Edwardsville

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Southern Illinois University Edwardsville

ClinicalTrials.gov Identifier:

NCT03700827

Other Study ID Numbers:

16-1208-4C-2

First Posted:

Oct 9, 2018

Last Update Posted:

Oct 4, 2021

Last Verified:

Mar 1, 2021

Individual Participant Data (IPD) Sharing Statement:

Undecided

Plan to Share IPD:

Undecided

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by Southern Illinois University Edwardsville

Abdominal Fat

Visceral Adipose Tissue

Subcutaneous Adipose Tissue

Exercise

Intervention

Additional relevant MeSH terms:

Obesity, Abdominal

Study Results

No Results Posted as of Oct 4, 2021