Comparing EVCO and EVOO

• Sponsor: Ankara City Hospital Bilkent (Other)
• Overall Status: Completed
• CT.gov ID: NCT04738929
• Collaborator: Hacettepe University (Other)
• Enrollment: 20
• Location: 1
• Arms: 2
• Actual Duration (Months): 5
• Patients Per Site Per Month: 4

Study Details

Study Description

Brief Summary

The aim of this study is to compare acute effects of consuming extra virgin coconut oil (EVCO) as a source of medium chain fatty acids and extra virgin olive oil (EVOO) as a source of long chain fatty acids in normal weight and obese subjects.

Condition or Disease	Intervention/Treatment	Phase
Obesity; Appetitive Behavior	Other: Extra virgin coconut oil or extra virgin olive oil	N/A

Detailed Description

Twenty male subjects (10 normal weight; 10 obese) consumed breakfast meals containing skimmed milk, fat-free white cheese, bread and EVCO (25 g) or EVOO (25 g). Visual analog scale evaluations, resting metabolic rate measurements and selected blood parameters analysis (glucose, triglyceride, insulin and plasma peptide YY) were performed before and after the test breakfast meals. In addition, energy intakes were evaluated by ad libitum lunch meal at 180 min.

Study Design

• Study Type: Interventional
• Actual Enrollment: 20 participants
• Allocation: Randomized
• Intervention Model: Crossover Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: Comparing Acute Effects of Extra Virgin Coconut Oil and Extra Virgin Olive Oil Consumption on Appetite and Food Intake in Normal Weight and Obese Male Subjects
• Actual Study Start Date: Jan 3, 2019
• Actual Primary Completion Date: Jun 3, 2019
• Actual Study Completion Date: Jun 3, 2019

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Normal weight Normal weight subjects (BMI=18.5-25)	Other: Extra virgin coconut oil or extra virgin olive oil; Subjects consumed standard breakfast meals containing "extra virgin coconut oil" or "extra virgin olive oil"
Experimental: Obese Obese subjects (BMI=30-34.99)	Other: Extra virgin coconut oil or extra virgin olive oil; Subjects consumed standard breakfast meals containing "extra virgin coconut oil" or "extra virgin olive oil"

Outcome Measures

Primary Outcome Measures

1. Energy expenditure change [0, 60, 120, 180 minutes]

   kcal

2. Subjective appetite feelings change [0, 30, 60, 120, 180 minutes]

   visual analogue scales rating (0-10 cm)

3. glucose change [0, 30, 60, 120, 180 minutes]

   mg/dl

4. insulin change [0, 30, 60, 120, 180 minutes]

   mU/L

5. peptide YY change [0, 30, 60, 120, 180 minutes]

   pg/dl

6. triglycerides change [0, 30, 60, 120, 180 minutes]

   mg/dl

7. Ad libitum energy intake [180 minute]

   kcal

Eligibility Criteria

Criteria

• Ages Eligible for Study: 19 Years to 40 Years
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Metabolically healthy

• Aged 19-40 years

• Normal weight (BMI=18.5-24.9 kg/m²) and obese men (BMI=30-34.99 kg/m²)

Exclusion Criteria:

• smoking,

• alcohol consumption,

• weight gain/loss recently (> %5, in three months),

• any genetic and metabolic diseases,

• any food allergy/intolerance,

• any medication,

• restrained eating habits.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Presidency of Republic of Turkey Health Center	Ankara		Turkey

Sponsors and Collaborators

• Ankara City Hospital Bilkent
• Hacettepe University

Investigators

• Principal Investigator: Ziya Erokay Metin, Dr., Ankara City Hospital Bilkent
• Study Chair: Pelin Bilgiç, Assoc. Prof., Hacettepe University
• Study Chair: Mercan Merve Tengilimoğlu Metin, Assis. Prof., Hacettepe University
• Study Chair: Muzaffer Akkoca, Assoc. Prof., Saglik Bilimleri Universitesi

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Ziyaerokaymetin, Principal Investigator, Ankara City Hospital Bilkent
• ClinicalTrials.gov Identifier: NCT04738929
• Other Study ID Numbers: EVCO
• First Posted: Feb 4, 2021
• Last Update Posted: Feb 4, 2021
• Last Verified: Feb 1, 2021

• Individual Participant Data (IPD) Sharing Statement: No
• Plan to Share IPD: No
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Keywords provided by Ziyaerokaymetin, Principal Investigator, Ankara City Hospital Bilkent: Extra virgin coconut oil; medium chain fatty acids; extra virgin olive oil; obesity; peptide YY; resting metabolic rate.
• Additional relevant MeSH terms: Obesity

Study Results

No Results Posted as of Feb 4, 2021