Role of Dopamine Transporter in Glucose Control
Sponsor
Pusan National University Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT03466697
Collaborator
(none)
40
1
1
45.2
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Study Details
Study Description
Brief Summary
Healthy subjects will be enrolled in this study. Each subject will be scanned twice with F18-FP-CIT PET which is commercially available. F18-FP-CIT reflects dopamine transporter availability of striatum. Before each PET scan, subject will be injected either glucose or normal saline. Therefore, PET scan will reflect the changes of dopamine transporter availability after the injection of glucose.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Study Type:
Interventional
Actual Enrollment
:
40 participants
Allocation:
N/A
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Other
Official Title:
Role of Dopamine Transporter in Glucose Loading of Healthy Subjects
Actual Study Start Date
:
Mar 14, 2018
Actual Primary Completion Date
:
Dec 20, 2021
Actual Study Completion Date
:
Dec 20, 2021
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Other: Healthy subjects All subjects will be injected twice for each visit (normal saline or glucose) |
Other: Glucose injection/Normal saline injection
Before each PET scan, subject will be injected either glucose or normal saline.
|
Outcome Measures
Primary Outcome Measures
- Specific binding ratio of dopamine transporter availabilitiy measured from PET scans [less than 1 month]
Specific binding ratio of dopamine transporter availabilitiy measured from PET scans
Eligibility Criteria
Criteria
Ages Eligible for Study:
20 Years
to 40 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
- healthy subjects
Exclusion Criteria:
-
known neurologic disorder
-
known drug addiction
-
known endocrine disorder
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Pusan National University Hospital | Busan | Korea, Republic of | 49241 |
Sponsors and Collaborators
- Pusan National University Hospital
Investigators
- Principal Investigator: Kyoungjune Pak, MD, PhD, Pusan National University Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Kyoungjune Pak,
Clinical Assistant Professor,
Pusan National University Hospital
ClinicalTrials.gov Identifier:
NCT03466697
Other Study ID Numbers:
- 1707-019-057
First Posted:
Mar 15, 2018
Last Update Posted:
Apr 20, 2022
Last Verified:
Apr 1, 2022
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No