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Acute Effects of Fats on Satiety and Energy Needs

Sponsor
USDA Grand Forks Human Nutrition Research Center (U.S. Fed)
Overall Status
Completed
CT.gov ID
NCT02496936
Collaborator
(none)
23
Enrollment
1
Location
5
Arms
46.9
Actual Duration (Months)
0.5
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to assess the acute effect of dietary fat on satiety and energy metabolism.

Condition or Disease Intervention/Treatment Phase
  • Other: SFA
  • Other: MUFA
  • Other: PUFA-LA
  • Other: ALA
  • Other: LCn3
 N/A

Detailed Description

The influences of specific dietary fat sources on satiety, appetite and energy utilization remains unclear; evidence is lacking on whether responses vary according to acute intake. The researchers will use a controlled setting to determine whether the source of dietary fat is related to perceived satiety, satiety hormone responses, and energy expenditure by conducting experiments to evaluate short term (acute) effects.

Study Design

Study Type:
Interventional
Actual Enrollment :
23 participants
Allocation:
Randomized
Intervention Model:
Crossover Assignment
Masking:
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose:
Other
Official Title:
Acute Effects of Fats on Satiety and Energy Needs
Actual Study Start Date :
Dec 1, 2015
Actual Primary Completion Date :
Oct 30, 2019
Actual Study Completion Date :
Oct 30, 2019

Arms and Interventions

Arm Intervention/Treatment
Experimental: Saturated Fat (SFA)

30 grams saturated fat in the form of heavy whipping cream will be provided to subject in a smoothie drink

Other: SFA
High saturated fatty acid/SFA oil source
Experimental: Monounsaturated Fat (MUFA)

30 grams monounsaturated fat in the form of high oleic canola oil will be provided to subject in a smoothie drink

Other: MUFA
High monounsaturated fatty acid/MUFA oil source
Experimental: Polyunsaturated Fat Linoleic (PUFA-LA)

30 grams polyunsaturated fat in the form of high linoleic sunflower oil will be provided to subject in a smoothie drink

Other: PUFA-LA
High polyunsaturated fatty acid (linoleic)/PUFA-LA oil source
Experimental: Polyunsaturated Fat Alpha-Linolenic (ALA)

30 grams polyunsaturated fat in the form of flaxseed oil will be provided to subject in a smoothie drink

Other: ALA
High polyunsaturated fatty acid (alpha-linolenic)/ALA oil source
Experimental: Polyunsaturated Fat Long Chain Omega-3 (LCn3)

30 grams polyunsaturated fat in the form of fish oil (Coromega Omega3 Squeeze) will be provided to subject in a smoothie drink

Other: LCn3
High polyunsaturated fatty acid (omega-3)/LCn3 oil source

Outcome Measures

Primary Outcome Measures

  1. Acute effect of fat intake on energy expenditure as determined by metabolic rate [Incremental Area Under the Curve (iAUC) of metabolic rate from 0 to 4 hours]

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 50 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:

  • body mass index between 18.0-34.9 kg/m2

  • free of major diagnosed, untreated medical conditions

  • controlled hypertension

  • non-smoking or use of other tobacco products, including e-cigarettes

  • not taking steroid-based medications

  • not planning to or currently attempting to gain or lose weight

  • willing to comply with study demands

  • use of oral contraceptives

  • low intake of long chain omega 3 fatty acids

Exclusion Criteria:

  • diagnosed eating disorders

  • diabetes (blood sugar ≥ 126 mg/dl)

  • hypertension (systolic ≥ 160 mmHg or diastolic > 100 mmHg)

  • diagnosed cardiovascular, pulmonary, skeletal and metabolic disease

  • currently pregnant or planning to become pregnant, or lactating

  • taking medications known to affect appetite, blood lipids, body composition, body weight, or food intake (appetite control drugs, steroids, antidepressants)

Contacts and Locations

Locations

Site City State Country Postal Code
1 USDA Grand Forks Human Nutrition Research Center Grand Forks North Dakota United States 58203

Sponsors and Collaborators

  • USDA Grand Forks Human Nutrition Research Center

Investigators

  • Principal Investigator: Matthew Picklo, PhD, USDA Grand Forks Human Nutrition Research Center

Study Documents (Full-Text)

More Information

Additional Information:

Publications

None provided.
Responsible Party:
USDA Grand Forks Human Nutrition Research Center
ClinicalTrials.gov Identifier:
NCT02496936
Other Study ID Numbers:
  • GFHNRC508
First Posted:
Jul 14, 2015
Last Update Posted:
Aug 4, 2022
Last Verified:
Aug 1, 2022
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by USDA Grand Forks Human Nutrition Research Center
Energy Expenditure
Appetite
Satiety

Study Results

No Results Posted as of Aug 4, 2022