Effects of Probiotic Capsules in Promoting Fat Excretion by Human Trial
Study Details
Study Description
Brief Summary
The purpose of this study was to evaluate the efficacy of 2 capsules (500 mg per capsule, 1000 mg per day) of Grape King Probiotic Capsules per day in promoting fat excretion in obese patients by clinical human food test.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
This experiment is carried out in a controlled manner. Before the subjects enter the research experiment, they need to follow their original lifestyle. The habits of maintaining a constant body weight for more than 2 weeks before the test, such as calorie balance in the diet and the amount of activity. Then enter the test to carry out the evaluation test of probiotics to the end. 60 subjects were randomized, 20 to placebo and 40 to probiotics. The subjects took two capsules of Grape King probiotics daily, a total of 1000 mg. Continue to take it for 4 weeks, and perform blood routine tests. Body composition detection, waist and hip circumference measurement, related index analysis and 24-hour dietary questionnaires, gut health questionnaires and stool samples were collected and analyzed for 4 weeks before and after treatment.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Probiotics Probiotic capsules, 500 mg each, two daily for a total of 1000 mg for 4 weeks |
Dietary Supplement: probiotics
Eat a capsule for once, and twice a day
|
| Placebo Comparator: Placebo The placebo capsules had the same composition as the experimental capsules, except that they did not contain probiotics, and should be used for 4 weeks. |
Dietary Supplement: placebo
Eat a capsule for once, and twice a day
|
Outcome Measures
Primary Outcome Measures
- Change from baseline fecel lipid weight at week 4 [Week0, Week4]
Compared the difference of fecel lipid weight level between the week 4 and 0
Eligibility Criteria
Criteria
Inclusion Criteria:
-
male or female participants
-
aged 20-40 years old
-
body mass index in 25-27 kg/m2
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body fat > 25% for men and > 30% for women
Exclusion Criteria:
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cancer, chronic heart disease, use drugs which pharmacological effects may affect immunity
-
having systemic infections
-
using probiotics.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Chung Shan Medical University | Taichung | South | Taiwan | 402 |
Sponsors and Collaborators
- Chung Shan Medical University
- Grape King Bio Ltd.
Investigators
- Principal Investigator: Yu-Jou Chien, PhD student, Chung Shan Medical University
- Principal Investigator: Xin-Bei Lin, MS student, Chung Shan Medical University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- CS2-22068