The Acute Effect of Exercise on Appetite Appetite-regulating Hormones and Inflammation in Children

• Sponsor: University of Toronto (Other)
• Overall Status: Completed
• CT.gov ID: NCT02619461
• Collaborator: (none)
• Enrollment: 22
• Location: 1
• Arms: 2
• Duration (Months): 14
• Patients Per Site Per Month: 1.6

Study Details

Study Description

Brief Summary

This study describes the effect of acute high intensity exercise at 70% VO2peak on inflammation, stress, appetite hormones and appetite in lean and obese children and adolescents.

Condition or Disease	Intervention/Treatment	Phase
Obesity	Other: Exercise	N/A

Detailed Description

In summary, exercise does induce a variety of metabolic mechanisms on a central and peripheral level, related to appetite other than solely gut peptides. The literature points towards a rather loose coupling when it comes to high intensity exercise and the suppression of food intake, without a clear explanation of the cause of exercise induced anorexia. This study is aimed to investigate high-intensity exercise and its effects on appetite and satiety hormones, inflammation, stress and eating behaviors on appetite and food intake.

The objective of the current study is to investigate the factors contributing to exercise-induced anorexia in lean and obese children, and maximize its translation into post-exercise suppression of food intake and promotion of negative energy balance particularly in obese children. It is hypothesized that high-intensity exercise would promote a greater suppression of food intake through suppression of appetite ratings via physiological mechanisms depending on stress and inflammation rather than gut peptides.

Study Design

• Study Type: Interventional
• Actual Enrollment: 22 participants
• Allocation: Randomized
• Intervention Model: Crossover Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: The Acute Effect of High Intensity Exercise on Appetite, Appetite-regulating Hormones, and Bio-markers of Inflammation and Stress in Lean and Obese Boys
• Study Start Date: Aug 1, 2014
• Actual Primary Completion Date: Jul 1, 2015
• Actual Study Completion Date: Oct 1, 2015

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Exercise Exercise at 70%VO2max on a recumbent bicycle for 30 minutes.	Other: Exercise; Exercise at 70%VO2max on a recumbent bicycle for 30 minutes to investigate the effects of exercise at high intensities on appetite and biomarkers of appetite and inflammation.
No Intervention: Control Resting

Outcome Measures

Primary Outcome Measures

1. Appetite as assessed via visual analog scales [Timeperiod of 2 hours during each study intervention.]

   Appetite will be assessed via visual analog scales. Each item will be scored from 0-100; 0 not hungry; 100 very hungry

2. Biomarkers of appetite [4 timpoints during 2 hours during each study intervention.]

   Biomarkers of appetite will be assessed such as A. Ghrelin; GLP-1; PYY and Leptin

3. Biomarkers of Inflammation [4 timpoints during 2 hours during each study intervention.]

   Biomarkers of inflammation will be assessed such as IL-6; IL-1beta; TNF-alpha; CRP

Secondary Outcome Measures

1. Biomarkers of Stress [4 timpoints during 2 hours during each study intervention.]

   Biomarkers of stress will be assessed such as Cortisol and Adrenalin

Eligibility Criteria

Criteria

• Ages Eligible for Study: 10 Years to 18 Years
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• 11 normal weight and 11 obese boys will be recruited for the study. Lean and obese boys aged 10-18 years, born full-term and with a normal body weight at birth, will be included in the study

Exclusion Criteria:

• Dieters and individuals with lactose intolerance, allergies to milk and dairy products and gastrointestinal problems will be excluded from the study.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Department of Nutritional Sciences	Toronto	Ontario	Canada	M5S 3E2

Sponsors and Collaborators

• University of Toronto

Investigators

• Principal Investigator: Harvey Anderson, University of Toronto

Study Documents (Full-Text)

None provided.

More Information

Publications

• Bozinovski NC, Bellissimo N, Thomas SG, Pencharz PB, Goode RC, Anderson GH. The effect of duration of exercise at the ventilation threshold on subjective appetite and short-term food intake in 9 to 14 year old boys and girls. Int J Behav Nutr Phys Act. 2009 Oct 9;6:66. doi: 10.1186/1479-5868-6-66.
• Hunschede S, El Khoury D, Antoine-Jonville S, Smith C, Thomas S, Anderson GH. Acute changes in substrate oxidation do not affect short-term food intake in healthy boys and men. Appl Physiol Nutr Metab. 2015 Feb;40(2):168-77. doi: 10.1139/apnm-2014-0188. Epub 2014 Oct 22.
• Tamam S, Bellissimo N, Patel BP, Thomas SG, Anderson GH. Overweight and obese boys reduce food intake in response to a glucose drink but fail to increase intake in response to exercise of short duration. Appl Physiol Nutr Metab. 2012 Jun;37(3):520-9. doi: 10.1139/h2012-038. Epub 2012 Apr 25.

• Responsible Party: G. Harvey Anderson, Study Investigator, University of Toronto
• ClinicalTrials.gov Identifier: NCT02619461
• Other Study ID Numbers: HIT_Exercise_Appetite_001
• First Posted: Dec 2, 2015
• Last Update Posted: Dec 2, 2015
• Last Verified: Nov 1, 2015

• Additional relevant MeSH terms: Inflammation

Study Results

No Results Posted as of Dec 2, 2015