Effects of Monosodium Glutamate on Energy Balance and Eating Behavior

Sponsor

USDA, Western Human Nutrition Research Center (U.S. Fed)

Overall Status

Completed

CT.gov ID

NCT01410838

Collaborator

Ajinomoto USA, INC. (Industry)

Enrollment

Location

Arms

Duration (Months)

1.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study will test whether regular consumption of Monosodium Glutamate (MSG) immediately prior to each of the three major meals (breakfast, lunch, dinner) inhibits body weight and fat regain following a period of moderate, yet clinically significant weight loss.

Condition or Disease	Intervention/Treatment	Phase
Obesity Weight Gain Food Preferences	Other: Broth Other: Broth	N/A

Detailed Description

The proposed study enables us to assess the long term effects of consuming MSG on body weight regain following weight loss.

Study Design

Study Type:

Interventional

Actual Enrollment :

44 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

Double (Participant, Investigator)

Primary Purpose:

Basic Science

Official Title:

Effects of Ingesting Monosodium Glutamate (MSG) on Energy Balance and Eating Behavior Following Moderate Energy Restriction and Weight Loss in Overweight Women

Study Start Date :

Aug 1, 2011

Actual Primary Completion Date :

Aug 1, 2014

Actual Study Completion Date :

Aug 1, 2014

Arms and Interventions

Arm	Intervention/Treatment
Placebo Comparator: Broth- NaCl Sodium chloride containing broth matched for sodium content to the MSG broth	Other: Broth 200 mL of sodium chloride containing broth, consumed three times per day
Active Comparator: Broth- MSG MSG containing broth with the same sodium content as the placebo comparator.	Other: Broth 200 mL of MSG containing broth consumed three times per day

Arm

Intervention/Treatment

Placebo Comparator: Broth- NaCl

Sodium chloride containing broth matched for sodium content to the MSG broth

Other: Broth

200 mL of sodium chloride containing broth, consumed three times per day

Active Comparator: Broth- MSG

MSG containing broth with the same sodium content as the placebo comparator.

Other: Broth

200 mL of MSG containing broth consumed three times per day

Outcome Measures

Primary Outcome Measures

Change in body weight [weeks 11, 12, and 25]
Subjects will have their body weight measured to determine the effect of MSG on body weight regain following weight loss.

Secondary Outcome Measures

Change in body fat [weeks 11 and 25]
Volunteers will have their body fat measured by DEXA (Dual X-ray Absorptiometry) to determine the effect of MSG on body fat regain following weight loss.
Change in eating behavior [weeks 11, 12 and 25]
The effect of MSG on eating behavior will be measured using questionnaires, sensory evaluation testing, stress responsivity, and liking and wanting tests, and appetite assessments.
Change in resting energy expenditure [weeks 11, 12, and 25]
The effect of MSG on resting energy expenditure will be measured using respiratory gas exchange using a metabolic cart system.

Eligibility Criteria

Criteria

Ages Eligible for Study:

19 Years to 50 Years

Sexes Eligible for Study:

Female

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Women
Age 19-45
BMI 27-35
Blood pressure <140/90
Non-smoking

Exclusion Criteria:

Anemic: hgb < 11.5 mg/dL
Sensitivity to MSG (self reported)
Pregnant or planning to get pregnant
Taking medication for hypertension, depression, or weight loss
Diabetic
Vegetarian
MRI Contraindications: internal metal, braces on teeth, history of metal in the eye, claustrophobia
blindness or heavily corrected vision
not fluent in English

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Western Human Nutrition Center, University of California Davis	Davis	California	United States	95616

Sponsors and Collaborators

USDA, Western Human Nutrition Research Center
Ajinomoto USA, INC.

Investigators

Principal Investigator: Kevin Laugero, PhD, WHNRC, ARS, University of California Davis

Study Documents (Full-Text)

None provided.

More Information

Additional Information:

USDA Western Human Nutrition Research Center

Publications

None provided.

Responsible Party:

USDA, Western Human Nutrition Research Center

ClinicalTrials.gov Identifier:

NCT01410838

Other Study ID Numbers:

WHNRC 222718-2

First Posted:

Aug 5, 2011

Last Update Posted:

May 21, 2015

Last Verified:

Aug 1, 2014

Keywords provided by USDA, Western Human Nutrition Research Center

Obesity

Food preferences

Eating Behavior

Additional relevant MeSH terms:

Weight Gain

Study Results

No Results Posted as of May 21, 2015