Observational Prospective Study on Behavioral Outcomes of Children With Autism Spectrum Disorder (ASD) in Comparison to Those Without Neurodevelopmental Diagnoses
Study Details
Study Description
Brief Summary
Autism Spectrum Disorder (ASD) is the fastest growing neurodevelopmental disorder in the world. Approximately 1% of the population worldwide is affected by this disorder. Children with ASD exhibit some very stereo-typical behaviors. Their daily functionality depends on very rigid and predictable schedules and routines. Any changes in their schedules can often trigger negative emotional outbursts. The need to come to the hospital for procedures can be one such trigger. The purpose of this study is to examine the post anesthesia behavior outcomes of children with ASD.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Autism Spectrum Disorder Patients with a diagnosis of autism spectrum disorder |
Other: Observation
Patients will be observed before and after they receive anesthesia
|
| Controls Patients with no developmental diagnoses |
Other: Observation
Patients will be observed before and after they receive anesthesia
|
Outcome Measures
Primary Outcome Measures
- Incidence of postoperative behavioral changes in the participants [up to two weeks following anesthesia]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patients aged 2 years through 17 years of age scheduled for a procedure with anesthesia at Boston Children's Hospital
-
Patients must have a diagnosis of Autism Spectrum Disorder (ASD) according to the DSM IV and DSM V (autism group) or an ASA score of I or II and no history of neurodevelopmental concerns (control group)
Exclusion Criteria:
-Families who are not able to read and speak English well enough to complete the validated surveys
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Boston Children's Hospital | Boston | Massachusetts | United States | 02115 |
Sponsors and Collaborators
- Boston Children's Hospital
Investigators
- Principal Investigator: Bistra Vlassakova, MD, Boston Children's Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
- Arnold B, Elliott A, Laohamroonvorapongse D, Hanna J, Norvell D, Koh J. Autistic children and anesthesia: is their perioperative experience different? Paediatr Anaesth. 2015 Nov;25(11):1103-10. doi: 10.1111/pan.12739. Epub 2015 Sep 4.
- Taghizadeh N, Davidson A, Williams K, Story D. Autism spectrum disorder (ASD) and its perioperative management. Paediatr Anaesth. 2015 Nov;25(11):1076-84. doi: 10.1111/pan.12732. Epub 2015 Aug 6. Review.
- van der Walt JH, Moran C. An audit of perioperative management of autistic children. Paediatr Anaesth. 2001 Jul;11(4):401-8.
- P00021473