Obsessions and Suicidality in Youth With Bipolar 1 Disorder

• Sponsor: Cairo University (Other)
• Overall Status: Completed
• CT.gov ID: NCT05878808
• Collaborator: (none)
• Enrollment: 80
• Location: 1
• Actual Duration (Months): 11.1
• Patients Per Site Per Month: 7.2

Study Details

Study Description

Brief Summary

Obsessive-compulsive disorder (OCD) is a common co-morbidity with bipolar I disorder, a comorbidity that is known to increase suicide risk. This study aimed to assess the presence of OCD in youth diagnosed with bipolar I disorder & to evaluate the association between OCD and suicide in the same cohort.

Eighty subjects diagnosed with bipolar I disorder were enrolled in this study, subjects were divided according to the presence or absence of OCD to Group A: Bipolar disorder patients with OCD (n = 26), Group B: Bipolar disorder patients without OCD (n = 54). The following scales were applied: Dimensional Yale-Brown obsessive compulsive scale (DYBOCS)- Beck scale for Suicidal ideations (BSSI) - Hamilton depression rating scale (HDRS) and Young mania rating scale (YMRS).

The results revealed that DYBOCS score of group A was 30.23±0.43, & of group B was 18.50±1.88 with a significant difference (p<0.01). There was a significantpositive correlation between BSSI and age, age of onset and YMRS in Group A (p<0.01).

The study demonstrated that OCD is a common comorbidity in youth with bipolar I disorder and may be associated with a greater risk of suicide than in youth with bipolar I disorder without co-morbid OCD. Furthermore, co-morbidity of OCD with bipolar I disorder in youth may be associated with younger age of onset and more severe symptoms profile.

Condition or Disease	Intervention/Treatment	Phase
Obsessions; Suicide; Bipolar I Disorder; Obsessive-Compulsive Disorder	Diagnostic Test: Psychometric assessment

Study Design

• Study Type: Observational
• Actual Enrollment: 80 participants
• Observational Model: Case-Control
• Time Perspective: Cross-Sectional
• Official Title: Obsessions and Suicide in Youth With Bipolar 1 Disorder
• Actual Study Start Date: Feb 1, 2022
• Actual Primary Completion Date: Sep 15, 2022
• Actual Study Completion Date: Jan 5, 2023

Arms and Interventions

Arm	Intervention/Treatment
Cases with ocd	Diagnostic Test: Psychometric assessment; Eighty subjects diagnosed with bipolar I disorder were enrolled in this study, subjects were divided according to the presence or absence of OCD to Group A: Bipolar disorder patients with OCD (n = 26), Group B: Bipolar disorder patients without OCD (n = 54). The following scales were applied: Dimensional Yale-Brown obsessive compulsive scale (DYBOCS)- Beck scale for Suicidal ideations (BSSI) - Hamilton depression rating scale (HDRS) and Young mania rating scale (YMRS).
Cases without ocd	Diagnostic Test: Psychometric assessment; Eighty subjects diagnosed with bipolar I disorder were enrolled in this study, subjects were divided according to the presence or absence of OCD to Group A: Bipolar disorder patients with OCD (n = 26), Group B: Bipolar disorder patients without OCD (n = 54). The following scales were applied: Dimensional Yale-Brown obsessive compulsive scale (DYBOCS)- Beck scale for Suicidal ideations (BSSI) - Hamilton depression rating scale (HDRS) and Young mania rating scale (YMRS).

Outcome Measures

Primary Outcome Measures

1. Association of OCD with bipolar I disorder [1 year]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 15 Years to 24 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Can read and write, agreed to sign the consent, diagnosed with bipolar I disorder

Exclusion Criteria:

• refused to sign the consent, active manic phase, recent substance use

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Cairo University	Cairo		Egypt

Sponsors and Collaborators

• Cairo University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Doaa Riad abd Elgabbar ayoub, Assist professor, Cairo University
• ClinicalTrials.gov Identifier: NCT05878808
• Other Study ID Numbers: MS-545- 2021
• First Posted: May 26, 2023
• Last Update Posted: May 26, 2023
• Last Verified: May 1, 2023

• Individual Participant Data (IPD) Sharing Statement: No
• Plan to Share IPD: No
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Keywords provided by Doaa Riad abd Elgabbar ayoub, Assist professor, Cairo University: BSSI; DYBOCS; Bipolar disorder
• Additional relevant MeSH terms: Disease; Suicide; Obsessive-Compulsive Disorder; Obsessive Behavior

Study Results

No Results Posted as of May 26, 2023