EmRT: Computerized Training for Individuals Diagnosed With Obsessive-Compulsive and Related Disorders

Sponsor

Stanford University (Other)

Overall Status

Active, not recruiting

CT.gov ID

NCT03182075

Collaborator

(none)

Enrollment

Location

Arms

77.1

Anticipated Duration (Months)

0.5

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Obsessive-Compulsive Disorder (OCD) is a chronic and disabling disorder that costs the economy over $2 billion annually and represents a significant public health problem. This study aims to build on our understanding of aberrant emotional processing in OCD. The proposed project tests whether a computerized training aimed to alter emotional processes, can relieve repetitive thoughts and behaviors.

Condition or Disease	Intervention/Treatment	Phase
Obsessive Compulsive Disorder	Behavioral: Computerized Training	N/A

Study Design

Study Type:

Interventional

Anticipated Enrollment :

40 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

Single (Participant)

Primary Purpose:

Supportive Care

Official Title:

Emotional Reactivity Training for Obsessive-Compulsive and Related Disorders

Actual Study Start Date :

Apr 30, 2018

Anticipated Primary Completion Date :

Jul 1, 2024

Anticipated Study Completion Date :

Oct 1, 2024

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Active Training OCD participants will receive active emotional reactivity training (14 sessions) via computer.	Behavioral: Computerized Training OCD participants will receive 14 sessions of training via computer within 3 weeks.
Sham Comparator: Passive Training OCD participants will receive passive computerized training (14 sessions) via computer.	Behavioral: Computerized Training OCD participants will receive 14 sessions of training via computer within 3 weeks.

Arm

Intervention/Treatment

Experimental: Active Training

OCD participants will receive active emotional reactivity training (14 sessions) via computer.

Behavioral: Computerized Training

OCD participants will receive 14 sessions of training via computer within 3 weeks.

Sham Comparator: Passive Training

OCD participants will receive passive computerized training (14 sessions) via computer.

Behavioral: Computerized Training

OCD participants will receive 14 sessions of training via computer within 3 weeks.

Outcome Measures

Primary Outcome Measures

Yale-Brown Obsessive Compulsive Scale (for participants diagnosed with OCD) [up to 2 months]
Improvement in OCD severity is measured by the YBOCS (Yale Brown Obsessive-Compulsive Scale), a gold standard measure of obsessions and compulsions. For the YBOCS the minimum units are 0 and Maximum units on the total scale are 40. The higher the number on the YBOCS, the more severe the symptoms. Response is defined as at least a 35% reduction on the YBOCS.
Savings Inventory Revised Scale (for participants diagnosed with hoarding disorder) [up to 2 months]
The SI-R is a 23-item questionnaire with 3 factor-analytically defined sub-scales for difficulty discarding, excessive clutter, and compulsive acquisition.