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Correlation Between Serum Uric Acid and Pulmonary Hypertension in Obstructive Sleep Apnea Syndrome

Sponsor
Alexandria University (Other)
Overall Status
Completed
CT.gov ID
NCT05967754
Collaborator
(none)
100
Enrollment
1
Location
1
Arm
35
Actual Duration (Months)
2.9
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study aimed to correlate serum uric acid levels and PAH in OSAHS patients.

Condition or Disease Intervention/Treatment Phase
  • Diagnostic Test: polysomnography
 N/A

Detailed Description

Obstructive sleep apnea-hypopnea syndrome is the most common form of SRBDs. Recurrent hypoxia, that accompanies OSAHS increases the degradation of ATP, which in turn increase uric acid concentration that can be used as a biomarker of tissue hypoxia in OSAHS. There is still debate about whether OSAHS is an independent contributor to pulmonary arterial hypertension.

AIM OF THE WORK This study aimed to correlate serum uric acid levels and PAH in OSAHS patients. Methods We enrolled 100 patients diagnosed with OSAHS using polysomnography. Patients were divided into three severity groups: mild OSA (5 ≤ AHI < 15), moderate OSA (15 ≤ AHI < 30), and severe (30 ≤ AHI < 60). Serum uric acid was measured the morning after polysomnography. All patients underwent standard echocardiograms, and Pulmonary artery systolic pressure calculation was done.

Study Design

Study Type:
Interventional
Actual Enrollment :
100 participants
Allocation:
N/A
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Screening
Official Title:
Correlation Between Serum Uric Acid and Pulmonary Arterial Hypertension Based on Echo Probability in Patients With Obstructive Sleep Apnea Syndrome
Actual Study Start Date :
Jan 1, 2018
Actual Primary Completion Date :
Oct 1, 2020
Actual Study Completion Date :
Dec 1, 2020

Arms and Interventions

Arm Intervention/Treatment
Other: Patients with Obstructive sleep Apnea

Patients with Obstructive sleep Apnea

Diagnostic Test: polysomnography
polysomnography and serum uric acid measurement

Outcome Measures

Primary Outcome Measures

  1. This study aimed to correlate serum uric acid levels and Pulmonary Arterial Hypertension in Obstructive Sleep Apnea Hypopnea Syndrome patients. [one Year]

    This study aimed to correlate serum uric acid levels and Pulmonary Arterial Hypertension in Obstructive Sleep Apnea Hypopnea Syndrome patients.

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:

  • Clinical diagnosis of OSAHS by overnight polysomnography (AHI ≥ 5/ hr)

  • ≥18 years old.

Exclusion Criteria:

  • Other sleep disorders as narcolepsy or hypersomnia were excluded as well as Patients with neuropsychiatric disorders.

  • Hemodynamically unstable patients

  • Patients with other chronic respiratory or cardiac diseases

  • Patients with other known causes of pulmonary hypertension

  • Patients with any disease or on medication that could alter excretion or urinary metabolism of uric acid such as Excessive uric acid production

Contacts and Locations

Locations

Site City State Country Postal Code
1 Rania Ahmad Sweed Alexandria Egypt 000000

Sponsors and Collaborators

  • Alexandria University

Investigators

  • Principal Investigator: rania A SEWIED, doctor, alex

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Rania Ahmad Sweed, clinical professor, Alexandria University
ClinicalTrials.gov Identifier:
NCT05967754
Other Study ID Numbers:
  • 24/327
First Posted:
Aug 1, 2023
Last Update Posted:
Aug 1, 2023
Last Verified:
Jul 1, 2023
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:
Apnea
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Hypertension

Study Results

No Results Posted as of Aug 1, 2023