Effects of Obstructive Sleep Apnea and/or Cigarette Smoking on Endothelial Function
Study Details
Study Description
Brief Summary
The hypothesis of this study is that either obstructive sleep apnea (OSA) or cigarette smoking (CS) exposure would produce oxidative stress and inflammation leading to endothelial injury, and the combined exposure would be additive or synergistic.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| smoker, with high apnea-hypopnea index subjects who smoke either in the past or currently, with confirmed moderate-severe OSA |
|
| smoker, mild OSA or without OSA subjects who smoke either in the past or currently, with mild OSA or without OSA |
|
| nonsmoker, with high apnea-hypopnea index subjects who never smoke, with confirmed moderate-severe OSA |
|
| nonsmoker, with mild OSA or without OSA subjects who never smoke, with mild OSA or without OSA |
Outcome Measures
Primary Outcome Measures
- reactive hyperemia induced peripheral arterial tone (RH-RAT) index [baseline]
Secondary Outcome Measures
- circulatory metabolic and vascular inflammatory biomarkers [baseline]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
No acute illness
-
No hospitalization in past 4 weeks
-
Absence of medical comorbidity such as hypertension, ischemic heart disease, diabetes and hyperlipidemia, renal impairment, vasculitis or Raynaud's syndrome, peripheral vascular disease especially Buerger's disease, aortic disease (aortic aneurysm or dilatation), cancer, thrombocytopenia, coagulation disorder or other chronic medical illness
Exclusion Criteria:
- Mentally incapacitated
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Queen Mary Hospital | Hong Kong | Hong Kong | 852 |
Sponsors and Collaborators
- The University of Hong Kong
Investigators
- Principal Investigator: Mary SM Ip, MD, The University of Hong Kong
Study Documents (Full-Text)
None provided.More Information
Publications
- Barnoya J, Glantz SA. Cardiovascular effects of secondhand smoke: nearly as large as smoking. Circulation. 2005 May 24;111(20):2684-98. Review.
- Bernhard D, Wang XL. Smoking, oxidative stress and cardiovascular diseases--do anti-oxidative therapies fail? Curr Med Chem. 2007;14(16):1703-12. Review.
- El Solh AA, Akinnusi ME, Baddoura FH, Mankowski CR. Endothelial cell apoptosis in obstructive sleep apnea: a link to endothelial dysfunction. Am J Respir Crit Care Med. 2007 Jun 1;175(11):1186-91. Epub 2007 Feb 1.
- Itzhaki S, Lavie L, Pillar G, Tal G, Lavie P. Endothelial dysfunction in obstructive sleep apnea measured by peripheral arterial tone response in the finger to reactive hyperemia. Sleep. 2005 May;28(5):594-600.
- Kashyap R, Hock LM, Bowman TJ. Higher prevalence of smoking in patients diagnosed as having obstructive sleep apnea. Sleep Breath. 2001 Dec;5(4):167-72.
- Lavie L, Lavie P. Smoking interacts with sleep apnea to increase cardiovascular risk. Sleep Med. 2008 Mar;9(3):247-53. Epub 2007 May 21.
- UW 08-023